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The map label for this gene is tkt1 [H]

Identifier: 121997833

GI number: 121997833

Start: 1125586

End: 1127592

Strand: Reverse

Name: tkt1 [H]

Synonym: Hhal_1042

Alternate gene names: 121997833

Gene position: 1127592-1125586 (Counterclockwise)

Preceding gene: 121997834

Following gene: 121997832

Centisome position: 42.1

GC content: 69.46

Gene sequence:

>2007_bases
ATGGCGTCGACCGAACTGAGCCGACGAGAGCTCGCCAACGGCATTCGCGCCCTGGCCATGGACGCTGTCCAGAAGGCCAA
TTCCGGCCATCCCGGGGCGCCGATGGGCATGGCGGATATCGCCGAGGTGCTGTGGCGGGACTACCTGCGCCATGCGCCGC
AGAGGCCGGGCTGGTTCGACCGCGACCGCTTTGTCCTCTCCAATGGCCACGGTTCGATGTTGCAGTACGCACTGCTCCAT
CTGAGCGGTTACGACGTCTCCGTCGACGACCTCAAGAACTTCCGGCAGCTGCACTCGCGCACGCCGGGCCACCCGGAGTA
CGGCTACACCCCCGGCGTCGAGACCACCACCGGGCCGCTGGGCCAGGGGTTGGCCAACAGCGTCGGCATGGCGCTGGCCG
AGCGGATGCTGGCGGCGCGCTTCAACCGCCCTGGTCACGAGATCATCGACCACTACACCTACGTCTTCATGGGCGACGGC
TGCCTGATGGAGGGGGTCTCCCACGAGGCCTGCTCGCTGGCCGGCACTCTCGGCCTGGGCAAGCTGATCGCCTTCTATGA
CGACAACAGCATCTCCATCGACGGCAACGTCGAGGGCTGGTACACCGAGGACGTCCGTCAGCGCTTCGAGGCCTACGGCT
GGCAGGTGATCGGTCCCATCGACGGCCACGACGGCGAGGCCGTGCGCCAGGCCATTGAGCAGGCGCGCGCCGACACCAGC
CGTCCCACGCTGATCGACTGCAAGACGGTGATCGGCTTCGGTGCGCCGAATCAGTGCGGTACCGCCGGCGTGCACGGTGC
GCCGCTGGGCGAGGAGGAGATCGCGGCCTGTCGCAAGGAGCTCGGCTGGGAGCACGGTCCGTTCGAGATCCCCGACGCGC
ACTACCAGGCGTGGGATGGTCGCGGCCGGGGCGAGGAACTCCTGCAGGCCTGGGGCGAGCGCCTTGAGGCGTACCGCAAG
GAACACCCCGAGCTGGCCGATGAGCTGGAGCGGCGGATGCGCGGCGAGCTGCCGGGCAACTGGCAGGAGCTGGTCGCCGA
GGGCCTGGAGAAGTTCGCCGGCGGCAAGAAGGACGCCACTCGCAAGAGCTCCCAGGCGGTGCTCGGCCACTTCGGCCCGC
ACTTGCCCGAGCTGCTGGGTGGCTCTGCCGACCTGACCGGCTCCAACAACACCTGGTGGGACGGCTGCTCGACGGTCAGC
CAAGCGCAGGCCGACGGCAACTACGTCTTCTACGGTGTCCGCGAGTTCGGGATGACGGCGATCATGAACGGCGTCGCCCT
GCACGGCGGGTTCATCCCCTACGGCGGCACCTTCCTGATCTTCTCCGACTACGCGCGCAACGCTGTGCGCATGGCCGCGC
TGATGAAGCAGCGGGTGGTGATGGTCTACACCCACGACTCCATCGGCCTGGGCGAGGACGGCCCCACCCACCAGCCGATC
GAACAGCTGGCCAGCCTGCGCCTGATCCCCAACCTGCACGTCTGGCGCCCGTGCGACGCCCAGGAGACGGCTGCGGCCTG
GGCGGCGTCCATCGCCCGCGAGGACGGCCCGAGCATGCTGGCGCTGTCGCGCCAGGGCATGGAGCCGCAGCAGCGCAACG
GCGAGCAAGTCCGGTCCATCTCCCGTGGTGGCTACATCCTCAAGGAGGCCGGTTCCGGCAAGCCCGAACTGGTGATCCTG
GCCACGGGCTCCGAGGTGGATCTGGCCATGGCGGCCCGCGAGCAGCTCGAGGCCGAGGGGCGCGCGGTGCGCGTGGTCTC
CATGCCGTGTGTCGAGGCGTTCTGTGAGCAGGACGAGGCCTACCGGCAGCAGGTCCTGCCCGGTGACGTGCCGCGGGTGG
CCGTCGAGGCCGGCGCCACCGGCCTGTGGCAGGGCTGGGTCGGCCAGTGTGGCCTGGTGGTTGGCATCGACACCTTCGGC
GAATCGGCGCCGGGGCCCGAGCTCTACGAGCACTTCGGCCTGACCGCGGACAACGTCGCCACTGCGGGTCGGCGCGTCCT
CGGCTGA

Upstream 100 bases:

>100_bases
CTTTTGCCGACCGGTCGCGATCCGTAGAGTTTCGGGGCAGTATGGCGGCAAGCTCGACCTGGGCCGCATCAGAACAATAT
TCCATTGAGGGAGGTAGAAC

Downstream 100 bases:

>100_bases
GGGCGCCGGCCCGAGCGCAGAACAAGAATCGACGAGAGGAGAGTGGCCGTGAAAGCGAAGCGCATGACCGATCTGGACCT
GACGGGCAAGCGGGTGCTCA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MASTELSRRELANGIRALAMDAVQKANSGHPGAPMGMADIAEVLWRDYLRHAPQRPGWFDRDRFVLSNGHGSMLQYALLH
LSGYDVSVDDLKNFRQLHSRTPGHPEYGYTPGVETTTGPLGQGLANSVGMALAERMLAARFNRPGHEIIDHYTYVFMGDG
CLMEGVSHEACSLAGTLGLGKLIAFYDDNSISIDGNVEGWYTEDVRQRFEAYGWQVIGPIDGHDGEAVRQAIEQARADTS
RPTLIDCKTVIGFGAPNQCGTAGVHGAPLGEEEIAACRKELGWEHGPFEIPDAHYQAWDGRGRGEELLQAWGERLEAYRK
EHPELADELERRMRGELPGNWQELVAEGLEKFAGGKKDATRKSSQAVLGHFGPHLPELLGGSADLTGSNNTWWDGCSTVS
QAQADGNYVFYGVREFGMTAIMNGVALHGGFIPYGGTFLIFSDYARNAVRMAALMKQRVVMVYTHDSIGLGEDGPTHQPI
EQLASLRLIPNLHVWRPCDAQETAAAWAASIAREDGPSMLALSRQGMEPQQRNGEQVRSISRGGYILKEAGSGKPELVIL
ATGSEVDLAMAAREQLEAEGRAVRVVSMPCVEAFCEQDEAYRQQVLPGDVPRVAVEAGATGLWQGWVGQCGLVVGIDTFG
ESAPGPELYEHFGLTADNVATAGRRVLG

Sequences:

>Translated_668_residues
MASTELSRRELANGIRALAMDAVQKANSGHPGAPMGMADIAEVLWRDYLRHAPQRPGWFDRDRFVLSNGHGSMLQYALLH
LSGYDVSVDDLKNFRQLHSRTPGHPEYGYTPGVETTTGPLGQGLANSVGMALAERMLAARFNRPGHEIIDHYTYVFMGDG
CLMEGVSHEACSLAGTLGLGKLIAFYDDNSISIDGNVEGWYTEDVRQRFEAYGWQVIGPIDGHDGEAVRQAIEQARADTS
RPTLIDCKTVIGFGAPNQCGTAGVHGAPLGEEEIAACRKELGWEHGPFEIPDAHYQAWDGRGRGEELLQAWGERLEAYRK
EHPELADELERRMRGELPGNWQELVAEGLEKFAGGKKDATRKSSQAVLGHFGPHLPELLGGSADLTGSNNTWWDGCSTVS
QAQADGNYVFYGVREFGMTAIMNGVALHGGFIPYGGTFLIFSDYARNAVRMAALMKQRVVMVYTHDSIGLGEDGPTHQPI
EQLASLRLIPNLHVWRPCDAQETAAAWAASIAREDGPSMLALSRQGMEPQQRNGEQVRSISRGGYILKEAGSGKPELVIL
ATGSEVDLAMAAREQLEAEGRAVRVVSMPCVEAFCEQDEAYRQQVLPGDVPRVAVEAGATGLWQGWVGQCGLVVGIDTFG
ESAPGPELYEHFGLTADNVATAGRRVLG
>Mature_667_residues
ASTELSRRELANGIRALAMDAVQKANSGHPGAPMGMADIAEVLWRDYLRHAPQRPGWFDRDRFVLSNGHGSMLQYALLHL
SGYDVSVDDLKNFRQLHSRTPGHPEYGYTPGVETTTGPLGQGLANSVGMALAERMLAARFNRPGHEIIDHYTYVFMGDGC
LMEGVSHEACSLAGTLGLGKLIAFYDDNSISIDGNVEGWYTEDVRQRFEAYGWQVIGPIDGHDGEAVRQAIEQARADTSR
PTLIDCKTVIGFGAPNQCGTAGVHGAPLGEEEIAACRKELGWEHGPFEIPDAHYQAWDGRGRGEELLQAWGERLEAYRKE
HPELADELERRMRGELPGNWQELVAEGLEKFAGGKKDATRKSSQAVLGHFGPHLPELLGGSADLTGSNNTWWDGCSTVSQ
AQADGNYVFYGVREFGMTAIMNGVALHGGFIPYGGTFLIFSDYARNAVRMAALMKQRVVMVYTHDSIGLGEDGPTHQPIE
QLASLRLIPNLHVWRPCDAQETAAAWAASIAREDGPSMLALSRQGMEPQQRNGEQVRSISRGGYILKEAGSGKPELVILA
TGSEVDLAMAAREQLEAEGRAVRVVSMPCVEAFCEQDEAYRQQVLPGDVPRVAVEAGATGLWQGWVGQCGLVVGIDTFGE
SAPGPELYEHFGLTADNVATAGRRVLG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=672, Percent_Identity=26.0416666666667, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4507521, Length=672, Percent_Identity=26.0416666666667, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI133778974, Length=584, Percent_Identity=26.1986301369863, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI225637459, Length=681, Percent_Identity=21.8795888399413, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI225637461, Length=577, Percent_Identity=22.1837088388215, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI225637463, Length=577, Percent_Identity=22.1837088388215, Blast_Score=106, Evalue=8e-23,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=63.6500754147813, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=665, Percent_Identity=61.9548872180451, Blast_Score=880, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=593, Percent_Identity=25.2951096121417, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=665, Percent_Identity=47.5187969924812, Blast_Score=590, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=46.7669172932331, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45551847, Length=678, Percent_Identity=26.401179941003, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45550715, Length=678, Percent_Identity=26.401179941003, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24645119, Length=637, Percent_Identity=26.0596546310832, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24666278, Length=683, Percent_Identity=24.1581259150805, Blast_Score=133, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72586; Mature: 72455

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTELSRRELANGIRALAMDAVQKANSGHPGAPMGMADIAEVLWRDYLRHAPQRPGWFD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RDRFVLSNGHGSMLQYALLHLSGYDVSVDDLKNFRQLHSRTPGHPEYGYTPGVETTTGPL
CCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
GQGLANSVGMALAERMLAARFNRPGHEIIDHYTYVFMGDGCLMEGVSHEACSLAGTLGLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHCCCCHHHHHHHHHHCHH
KLIAFYDDNSISIDGNVEGWYTEDVRQRFEAYGWQVIGPIDGHDGEAVRQAIEQARADTS
HEEEEECCCEEEECCCCCCEEHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCC
RPTLIDCKTVIGFGAPNQCGTAGVHGAPLGEEEIAACRKELGWEHGPFEIPDAHYQAWDG
CCCEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
RGRGEELLQAWGERLEAYRKEHPELADELERRMRGELPGNWQELVAEGLEKFAGGKKDAT
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHH
RKSSQAVLGHFGPHLPELLGGSADLTGSNNTWWDGCSTVSQAQADGNYVFYGVREFGMTA
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHH
IMNGVALHGGFIPYGGTFLIFSDYARNAVRMAALMKQRVVMVYTHDSIGLGEDGPTHQPI
HHHCHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHH
EQLASLRLIPNLHVWRPCDAQETAAAWAASIAREDGPSMLALSRQGMEPQQRNGEQVRSI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHCCHHHHHH
SRGGYILKEAGSGKPELVILATGSEVDLAMAAREQLEAEGRAVRVVSMPCVEAFCEQDEA
HCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCHHH
YRQQVLPGDVPRVAVEAGATGLWQGWVGQCGLVVGIDTFGESAPGPELYEHFGLTADNVA
HHHHCCCCCCCHHHHHCCCCHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHCCCHHHHH
TAGRRVLG
HCCHHHCC
>Mature Secondary Structure 
ASTELSRRELANGIRALAMDAVQKANSGHPGAPMGMADIAEVLWRDYLRHAPQRPGWFD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RDRFVLSNGHGSMLQYALLHLSGYDVSVDDLKNFRQLHSRTPGHPEYGYTPGVETTTGPL
CCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
GQGLANSVGMALAERMLAARFNRPGHEIIDHYTYVFMGDGCLMEGVSHEACSLAGTLGLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHCCCCHHHHHHHHHHCHH
KLIAFYDDNSISIDGNVEGWYTEDVRQRFEAYGWQVIGPIDGHDGEAVRQAIEQARADTS
HEEEEECCCEEEECCCCCCEEHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCC
RPTLIDCKTVIGFGAPNQCGTAGVHGAPLGEEEIAACRKELGWEHGPFEIPDAHYQAWDG
CCCEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
RGRGEELLQAWGERLEAYRKEHPELADELERRMRGELPGNWQELVAEGLEKFAGGKKDAT
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHH
RKSSQAVLGHFGPHLPELLGGSADLTGSNNTWWDGCSTVSQAQADGNYVFYGVREFGMTA
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHH
IMNGVALHGGFIPYGGTFLIFSDYARNAVRMAALMKQRVVMVYTHDSIGLGEDGPTHQPI
HHHCHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHH
EQLASLRLIPNLHVWRPCDAQETAAAWAASIAREDGPSMLALSRQGMEPQQRNGEQVRSI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHCCHHHHHH
SRGGYILKEAGSGKPELVILATGSEVDLAMAAREQLEAEGRAVRVVSMPCVEAFCEQDEA
HCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCHHH
YRQQVLPGDVPRVAVEAGATGLWQGWVGQCGLVVGIDTFGESAPGPELYEHFGLTADNVA
HHHHCCCCCCCHHHHHCCCCHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHCCCHHHHH
TAGRRVLG
HCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]