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The map label for this gene is rppH

Identifier: 121997676

GI number: 121997676

Start: 963529

End: 964074

Strand: Reverse

Name: rppH

Synonym: Hhal_0885

Alternate gene names: 121997676

Gene position: 964074-963529 (Counterclockwise)

Preceding gene: 121997680

Following gene: 121997675

Centisome position: 35.99

GC content: 70.7

Gene sequence:

>546_bases
GTGGTCGATTCAGACGGCTTTCGGCCCAATGTCGGCATCATCGTCGCCAACGACGACGGGCGGGTGCTGTGGGCTCGGCG
GGCCGGAGAAGACGCCTGGCAGTTTCCCCAGGGCGGGGTCGAGGCCAACGAGACCCCGCTGGAGGCGCTCTACCGCGAGC
TGCGCGAGGAAGTGGGCCTCGGGCCCGCCGACGTGGCCGTCCTCGGCGCCACGCGCCGCTGGCTGCGTTACCGCCTGCCC
CGCCGCATGATCCGTCGCCGAGGCAGCCGGTGCATCGGCCAGAAGCAGATCTGGTTCCTGCTGCGCCTGCTCGCCGACGA
GCAGCGGGTGCGCGTCGACCGGGTGGCGCGCCCCGAGTTTGACCGCTGGCGGTGGGTCGACTACTGGTATCCGGTCGAAG
AGGTCATCTTTTTCAAGCGCCAGGTGTACCGCCAGGCGCTGCAGGAACTCTCCGGCTATCTGCAGGCCGATGACTGGGCC
GGCACCGGCACCGAGGGTGGCCCCGCTGCGGTCATCCCGCCGGCGGCTCGGCGCCGATTGCGATAG

Upstream 100 bases:

>100_bases
ATGGGAAGGGGGGCGGCCTGGCGCTGCGGCAACGTTGCCCAGGTTGCGCCCACTGTGAAAGAATAACATCGGCTTTTTCT
GCGTAGGGAGGCGTCTCCGG

Downstream 100 bases:

>100_bases
GGCGGGGCTTGATGCTCGAAATCCTCCACCGCGTCTCCCGAGAAGTGAACGCCGCCCCGAACCTGCGCCAGGGGCTGCGG
ATCATCGTCGAGCGGGTCGC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MVDSDGFRPNVGIIVANDDGRVLWARRAGEDAWQFPQGGVEANETPLEALYRELREEVGLGPADVAVLGATRRWLRYRLP
RRMIRRRGSRCIGQKQIWFLLRLLADEQRVRVDRVARPEFDRWRWVDYWYPVEEVIFFKRQVYRQALQELSGYLQADDWA
GTGTEGGPAAVIPPAARRRLR

Sequences:

>Translated_181_residues
MVDSDGFRPNVGIIVANDDGRVLWARRAGEDAWQFPQGGVEANETPLEALYRELREEVGLGPADVAVLGATRRWLRYRLP
RRMIRRRGSRCIGQKQIWFLLRLLADEQRVRVDRVARPEFDRWRWVDYWYPVEEVIFFKRQVYRQALQELSGYLQADDWA
GTGTEGGPAAVIPPAARRRLR
>Mature_181_residues
MVDSDGFRPNVGIIVANDDGRVLWARRAGEDAWQFPQGGVEANETPLEALYRELREEVGLGPADVAVLGATRRWLRYRLP
RRMIRRRGSRCIGQKQIWFLLRLLADEQRVRVDRVARPEFDRWRWVDYWYPVEEVIFFKRQVYRQALQELSGYLQADDWA
GTGTEGGPAAVIPPAARRRLR

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=157, Percent_Identity=51.5923566878981, Blast_Score=182, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_HALHL (A1WVE9)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002463.1
- ProteinModelPortal:   A1WVE9
- SMR:   A1WVE9
- STRING:   A1WVE9
- GeneID:   4710137
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0885
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A1WVE9
- ProtClustDB:   PRK00714
- BioCyc:   HHAL349124:HHAL_0885-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 21094; Mature: 21094

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSDGFRPNVGIIVANDDGRVLWARRAGEDAWQFPQGGVEANETPLEALYRELREEVGL
CCCCCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
GPADVAVLGATRRWLRYRLPRRMIRRRGSRCIGQKQIWFLLRLLADEQRVRVDRVARPEF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DRWRWVDYWYPVEEVIFFKRQVYRQALQELSGYLQADDWAGTGTEGGPAAVIPPAARRRL
CCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHCC
R
C
>Mature Secondary Structure
MVDSDGFRPNVGIIVANDDGRVLWARRAGEDAWQFPQGGVEANETPLEALYRELREEVGL
CCCCCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
GPADVAVLGATRRWLRYRLPRRMIRRRGSRCIGQKQIWFLLRLLADEQRVRVDRVARPEF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DRWRWVDYWYPVEEVIFFKRQVYRQALQELSGYLQADDWAGTGTEGGPAAVIPPAARRRL
CCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA