Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 121997465

GI number: 121997465

Start: 750168

End: 752030

Strand: Reverse

Name: mutL [H]

Synonym: Hhal_0668

Alternate gene names: 121997465

Gene position: 752030-750168 (Counterclockwise)

Preceding gene: 121997466

Following gene: 121997464

Centisome position: 28.08

GC content: 73.54

Gene sequence:

>1863_bases
ATGACGACGCGCGGTATTCGTCCCCTGCCGGATAACCTGATCGACCAGATCGCCGCTGGCGAGGTGGTCGAGCGCCCCGG
TTCGGTGGTCAAGGAACTGGTGGAGAATAGCCTCGACGCTGGCGCCGGGCGTGTCGAGGTGCAGATTGAGCGCGGCGGCA
AGCAGCGTATCCGCATCGCCGATGACGGCGACGGCATCCCGCCCGAGGAGCTGGAGTTGGCGCTGCGCCGGCACGCCACC
AGCAAGCTCACCGGCCTCGAGGAGCTGGAGCGCATCGCCAGTCTGGGGTTCCGGGGGGAGGCCCTGCCGAGCATCGCTGC
CGTTTCGCGGCTGACGCTGGCCTCGCGCACCGCCGAGGCGGAGCTGGGCCATCAGCTGCGCTGTGACGGCGGCGCACTGG
GTGCGCCGGAACCGGTGGCTCACCCCCCGGGGACCACGGTCACCGTCGACGACCTGTTCTACAACACGCCAGGGCGTCGC
AAGTTCCTGCGCACCGAGCGCACCGAGCTCTACCACGTCCAGGAGGCGTTGCGCCGGCTGGCGCTGAGCCGCTTCGACGT
CGGTTTCTCGCTCGTCCATCAGGGGCGGCGGCTCTGGTCGGTGCCCCGGGCGGAGAGCGAGACGGAGCGGCACGAGCGTC
TGGCGGAGCTGCTCGGTCGTGCCTTTGCCGATCACGCCCTGGCGGTGGAGTTGGAGGGGGCCGGGCTGCAGCTGCGGGGC
TGGCTGGGGCTGCCTACGGCGGCGCGGCGCCAGGGGGATCTTCAGTACTTGTTCGTCAACGGCCGGCTGGTGCGCGACCG
GGGGGCGGCCCACGGCATCCGCCAGGCTTACAGCGACTGCCTCTACCGCGATCACTACCCGGCCTACGTCCTCTTTCTGG
AGATGGATCCGGCTCGGGTGGATGTCAACGTCCACCCCATGAAGCATGAGGTGCGTTTTCGCGACGGGCGGACGGTGCAC
GACTTCCTCGCCCGGCGCATCGCCGACGCCCTGGCCACCGCCGAGCCGGCCGGTGCCGCGGCACCGCCTGCGGCGGAGCG
GCCGCCGTCGGGCGCGCCGACCGGCCCCGGGCAACCGGCGGCGGCCGAGCGGACGGGGCCGGCCTCCGAAGGGCTCGGCG
GCACGGCGGAGCTGGGGCTGCCGCTGGCCGAGGCGCGGCAGCTCTATGGGGGCGCCGACGCCGCTGCCGAGGGCCCTGGC
GGCGCGGCTGAAGGGGCGTCGTCGGCCATTGCCGGATCCCCCGGGCCGTCGCAGACCCGGGACCGGGAGAGTGAGGCGAC
CCCGGAGCTCGGCTACGCCGTCGGGCAGATCCGCGACGCCTATATTCTGGCCGAGTCGCAGCGGGGGCTGGTGGTGGTGG
ACATGCACGCCGCCCACGAGCGGGTGGTCTACGAGCGGATGAAGGCGCAGCTGGTGGCGTCGGGGATCGCCACGCAGTCG
TTGCTGGTGCCGGTGAGTGTGCCGGTGACCCCGGCGGAGGCCGAGCGGGTGGAGCTGCACGCGGCTACGCTGGCCCGGGC
GGGTCTGGAGGTGGACCGCGCCGGCCCCGAGTCGGTGCGTGTTCACCGAGTACCGGCGCTGCTCGCCGAGGCCGACGCCG
CGGCCCTGGTCCGCGACGCGGTGGCGGCGCTGGAGTCCGAGGGGACCGGTGGGCGGGTCGAGGACCGGGTCCACGCGCTG
CTGGCGCAGATGGCCTGCCACGGGTCGGTCCGCGCCGGACGGCGTCTGGAGCGCGCCGAGATGGACGCCCTGCTGCGGGA
TATCGAGCGCACCCCGCGGGCGGCGCAGTGCAACCACGGGCGGCCGACCTACACCGTGCTCGACGACGAGGCGCTGGCCC
GGCTGTTCATGCGGGGGCGGTGA

Upstream 100 bases:

>100_bases
GCAGTACCAGGTCAGCACCGAGCGTCTGCGCGAGGTCAATGACCTCTCCGGGGATGGCATCCGTGCTGGCAGCACCCTGA
TCATCCCTTAGAATGCGCGC

Downstream 100 bases:

>100_bases
TGACGGCGCCGGTGCTCTGCATCATGGGGCCCACCGCGGTGGGCAAGAGCGAACTGGCCCTGTCCCTGGCCGAGCGGCTG
GGCGGTGAGATCGTCAGCGT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTTRGIRPLPDNLIDQIAAGEVVERPGSVVKELVENSLDAGAGRVEVQIERGGKQRIRIADDGDGIPPEELELALRRHAT
SKLTGLEELERIASLGFRGEALPSIAAVSRLTLASRTAEAELGHQLRCDGGALGAPEPVAHPPGTTVTVDDLFYNTPGRR
KFLRTERTELYHVQEALRRLALSRFDVGFSLVHQGRRLWSVPRAESETERHERLAELLGRAFADHALAVELEGAGLQLRG
WLGLPTAARRQGDLQYLFVNGRLVRDRGAAHGIRQAYSDCLYRDHYPAYVLFLEMDPARVDVNVHPMKHEVRFRDGRTVH
DFLARRIADALATAEPAGAAAPPAAERPPSGAPTGPGQPAAAERTGPASEGLGGTAELGLPLAEARQLYGGADAAAEGPG
GAAEGASSAIAGSPGPSQTRDRESEATPELGYAVGQIRDAYILAESQRGLVVVDMHAAHERVVYERMKAQLVASGIATQS
LLVPVSVPVTPAEAERVELHAATLARAGLEVDRAGPESVRVHRVPALLAEADAAALVRDAVAALESEGTGGRVEDRVHAL
LAQMACHGSVRAGRRLERAEMDALLRDIERTPRAAQCNHGRPTYTVLDDEALARLFMRGR

Sequences:

>Translated_620_residues
MTTRGIRPLPDNLIDQIAAGEVVERPGSVVKELVENSLDAGAGRVEVQIERGGKQRIRIADDGDGIPPEELELALRRHAT
SKLTGLEELERIASLGFRGEALPSIAAVSRLTLASRTAEAELGHQLRCDGGALGAPEPVAHPPGTTVTVDDLFYNTPGRR
KFLRTERTELYHVQEALRRLALSRFDVGFSLVHQGRRLWSVPRAESETERHERLAELLGRAFADHALAVELEGAGLQLRG
WLGLPTAARRQGDLQYLFVNGRLVRDRGAAHGIRQAYSDCLYRDHYPAYVLFLEMDPARVDVNVHPMKHEVRFRDGRTVH
DFLARRIADALATAEPAGAAAPPAAERPPSGAPTGPGQPAAAERTGPASEGLGGTAELGLPLAEARQLYGGADAAAEGPG
GAAEGASSAIAGSPGPSQTRDRESEATPELGYAVGQIRDAYILAESQRGLVVVDMHAAHERVVYERMKAQLVASGIATQS
LLVPVSVPVTPAEAERVELHAATLARAGLEVDRAGPESVRVHRVPALLAEADAAALVRDAVAALESEGTGGRVEDRVHAL
LAQMACHGSVRAGRRLERAEMDALLRDIERTPRAAQCNHGRPTYTVLDDEALARLFMRGR
>Mature_619_residues
TTRGIRPLPDNLIDQIAAGEVVERPGSVVKELVENSLDAGAGRVEVQIERGGKQRIRIADDGDGIPPEELELALRRHATS
KLTGLEELERIASLGFRGEALPSIAAVSRLTLASRTAEAELGHQLRCDGGALGAPEPVAHPPGTTVTVDDLFYNTPGRRK
FLRTERTELYHVQEALRRLALSRFDVGFSLVHQGRRLWSVPRAESETERHERLAELLGRAFADHALAVELEGAGLQLRGW
LGLPTAARRQGDLQYLFVNGRLVRDRGAAHGIRQAYSDCLYRDHYPAYVLFLEMDPARVDVNVHPMKHEVRFRDGRTVHD
FLARRIADALATAEPAGAAAPPAAERPPSGAPTGPGQPAAAERTGPASEGLGGTAELGLPLAEARQLYGGADAAAEGPGG
AAEGASSAIAGSPGPSQTRDRESEATPELGYAVGQIRDAYILAESQRGLVVVDMHAAHERVVYERMKAQLVASGIATQSL
LVPVSVPVTPAEAERVELHAATLARAGLEVDRAGPESVRVHRVPALLAEADAAALVRDAVAALESEGTGGRVEDRVHALL
AQMACHGSVRAGRRLERAEMDALLRDIERTPRAAQCNHGRPTYTVLDDEALARLFMRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=33.7386018237082, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=30.1829268292683, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=30.1829268292683, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=29.595015576324, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=29.6511627906977, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=29.6511627906977, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=29.7872340425532, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI91992162, Length=335, Percent_Identity=27.7611940298507, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992160, Length=335, Percent_Identity=27.7611940298507, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=27.8350515463918, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1790612, Length=328, Percent_Identity=54.5731707317073, Blast_Score=344, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=35.625, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=349, Percent_Identity=25.5014326647564, Blast_Score=130, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=355, Percent_Identity=30.9859154929577, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=25.1381215469613, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=716, Percent_Identity=20.1117318435754, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=396, Percent_Identity=22.7272727272727, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136968, Length=331, Percent_Identity=36.5558912386707, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17136970, Length=367, Percent_Identity=26.4305177111717, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66486; Mature: 66355

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRGIRPLPDNLIDQIAAGEVVERPGSVVKELVENSLDAGAGRVEVQIERGGKQRIRIA
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEE
DDGDGIPPEELELALRRHATSKLTGLEELERIASLGFRGEALPSIAAVSRLTLASRTAEA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGHQLRCDGGALGAPEPVAHPPGTTVTVDDLFYNTPGRRKFLRTERTELYHVQEALRRL
HCCCEEECCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALSRFDVGFSLVHQGRRLWSVPRAESETERHERLAELLGRAFADHALAVELEGAGLQLRG
HHHHHCCHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEE
WLGLPTAARRQGDLQYLFVNGRLVRDRGAAHGIRQAYSDCLYRDHYPAYVLFLEMDPARV
CCCCCHHHHCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEE
DVNVHPMKHEVRFRDGRTVHDFLARRIADALATAEPAGAAAPPAAERPPSGAPTGPGQPA
EEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAERTGPASEGLGGTAELGLPLAEARQLYGGADAAAEGPGGAAEGASSAIAGSPGPSQTR
CCCCCCCCCCCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DRESEATPELGYAVGQIRDAYILAESQRGLVVVDMHAAHERVVYERMKAQLVASGIATQS
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLVPVSVPVTPAEAERVELHAATLARAGLEVDRAGPESVRVHRVPALLAEADAAALVRDA
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
VAALESEGTGGRVEDRVHALLAQMACHGSVRAGRRLERAEMDALLRDIERTPRAAQCNHG
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPTYTVLDDEALARLFMRGR
CCEEEEECHHHHHHHHHCCC
>Mature Secondary Structure 
TTRGIRPLPDNLIDQIAAGEVVERPGSVVKELVENSLDAGAGRVEVQIERGGKQRIRIA
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEE
DDGDGIPPEELELALRRHATSKLTGLEELERIASLGFRGEALPSIAAVSRLTLASRTAEA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGHQLRCDGGALGAPEPVAHPPGTTVTVDDLFYNTPGRRKFLRTERTELYHVQEALRRL
HCCCEEECCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALSRFDVGFSLVHQGRRLWSVPRAESETERHERLAELLGRAFADHALAVELEGAGLQLRG
HHHHHCCHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEE
WLGLPTAARRQGDLQYLFVNGRLVRDRGAAHGIRQAYSDCLYRDHYPAYVLFLEMDPARV
CCCCCHHHHCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEE
DVNVHPMKHEVRFRDGRTVHDFLARRIADALATAEPAGAAAPPAAERPPSGAPTGPGQPA
EEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAERTGPASEGLGGTAELGLPLAEARQLYGGADAAAEGPGGAAEGASSAIAGSPGPSQTR
CCCCCCCCCCCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DRESEATPELGYAVGQIRDAYILAESQRGLVVVDMHAAHERVVYERMKAQLVASGIATQS
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLVPVSVPVTPAEAERVELHAATLARAGLEVDRAGPESVRVHRVPALLAEADAAALVRDA
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
VAALESEGTGGRVEDRVHALLAQMACHGSVRAGRRLERAEMDALLRDIERTPRAAQCNHG
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPTYTVLDDEALARLFMRGR
CCEEEEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA