Click here to switch to the map view.

The map label for this gene is engA

Identifier: 121997392

GI number: 121997392

Start: 665753

End: 667171

Strand: Reverse

Name: engA

Synonym: Hhal_0591

Alternate gene names: 121997392

Gene position: 667171-665753 (Counterclockwise)

Preceding gene: 121997393

Following gene: 121997390

Centisome position: 24.91

GC content: 69.77

Gene sequence:

>1419_bases
ATGTCTGCGGTAATCGCCCTGGTCGGGCGGCCGAATGTCGGCAAATCGACCCTGTTCAACCGGCTCACCGGCAGCCGCGA
CGCCCTCGTGGCGGATCACCCGGGCCTGACTCGGGACCGTCAGTATGGGATCGTGCGCCACCAGGGGGGCCACGCCGTGG
TGGTGGATACCGGAGGCATGGGGGAAGAACTCGAGGGGGTCGGCGGCTGCATGCACGAGCAGGCCCGGGCCGCCATCGCC
GGTGCCGATGCGGTCGTCTTCCTGGTCGACGGGCAGGCCGGGGCCACCGTCGGTGACGAGGAGATCGCCGCTGAGCTGCG
GCGAGCCCAGGTGCCGGTGTTCCTGGCGGTCAACAAGACCGACGGGCTCGACGCCGGGGTGGCGGCCGCCGATTTCCACG
GTCTGGGCCTGCAGCCGGTTCACGCCATCGCCGCGACGCGCGGTCGTGGGGTGGGCGAGCTGCTGGACGCCGTCTTCGCG
CTCCTGCCTCCCGCTGAGCCGGATGCGGTGGGCTCCGATGGCCCAGGCGGGATTCCGGTGGCGATGATCGGCCGGCCCAA
CGTCGGCAAATCCACGCTGGTCAATCGCCTCCTCGGCGAGGAGCGGGTGGTGGTCTACGACGAGCCGGGCACCACCCGCG
ACAGTATTGCCGTGCCGTTCGAGCGCGACGGGCAGCACTACACCCTCATCGACACCGCCGGGGTGCGGCGTCGCGCGCGG
GTTCAGGAGACGGTCGAGAAGTTCAGCGTGGTCAAGACCCTCGAGGCCATCGAGCGGGCCTCGGTGGTGATGCTGGTGAC
CGATGCCCAGGAAGGGATCACCGAGCAGGACGCGCACTTGGCCGGGCACGTCCTGCAGGCCGGGCGGGCGCTGGTATTGG
TCATCAACAAGTGGGACGGCCTGGATCCCGATCAGCGCCGCAAGGTACGGCGGGATCTGGATCTGCGCTTCGCCTTCCTC
GGTTTCGCCCGCCACCACTTCGTTTCGGCCCTGCACGGCAGTGGCGTCGGCCTGCTGCTCGAATCGGTGGAGCGCGCCCA
CGCCGCGGCACACCGGGATCTGGCCACGCCGGAACTCAACGACGCCCTGCAGGAGGCGCTGGCCAACCATCAGCCGCCGC
TCTCGCGGGGGCGGCGGATCAAGCTGCGCTACGCCCACCAGGGCGGCCACAACCCGCCGGTGATCGTGATCCACGGCAAC
CAGGTGCAGCGGCTGCCGCGGGCCTATATGCGCTACCTGGAGAACTTCTTCCGCGACACCTTTGACCTCTACGGGACGCC
GGTGCGCATCGAGTGCCGGGCCAGCGATAACCCCTTTGCCGACAAGCCCAACCAGCTTACCGAGCGCCAGCGCCGGCGGC
GCCAGCGGGTGATTCACCACGCCAAGAAGCGCGAGAAGAAGCGCAAGCGCCGCCGCTAG

Upstream 100 bases:

>100_bases
GGGCAGCGGCTCACGGGCCGTTGCCCCGTCCGTTATAATCCCCGCCCTCAGCCGCCGTTCAGCGCGGCACACTTGTCCCA
GCCAATGCGGGGAATGCCCA

Downstream 100 bases:

>100_bases
ACGGTCGGCGGGCTAGGTGCGGACCAGCACCACGGAGACGTTGTCCGGTCCGCCGGCATCCAGGGTGGCTTCGATCAGGT
CCTGGGCGCGCTGGTTCAGT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGMGEELEGVGGCMHEQARAAIA
GADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKTDGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFA
LLPPAEPDAVGSDGPGGIPVAMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRAR
VQETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDGLDPDQRRKVRRDLDLRFAFL
GFARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELNDALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGN
QVQRLPRAYMRYLENFFRDTFDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR

Sequences:

>Translated_472_residues
MSAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGMGEELEGVGGCMHEQARAAIA
GADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKTDGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFA
LLPPAEPDAVGSDGPGGIPVAMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRAR
VQETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDGLDPDQRRKVRRDLDLRFAFL
GFARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELNDALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGN
QVQRLPRAYMRYLENFFRDTFDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR
>Mature_471_residues
SAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGMGEELEGVGGCMHEQARAAIAG
ADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKTDGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFAL
LPPAEPDAVGSDGPGGIPVAMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRARV
QETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDGLDPDQRRKVRRDLDLRFAFLG
FARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELNDALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGNQ
VQRLPRAYMRYLENFFRDTFDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Homo sapiens, GI193082991, Length=189, Percent_Identity=30.1587301587302, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI193082988, Length=189, Percent_Identity=30.1587301587302, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082120, Length=492, Percent_Identity=53.4552845528455, Blast_Score=516, Evalue=1e-148,
Organism=Escherichia coli, GI1788919, Length=120, Percent_Identity=40, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI2367268, Length=92, Percent_Identity=39.1304347826087, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=224, Percent_Identity=25.8928571428571, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_HALHL (A1WUL5)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002179.1
- ProteinModelPortal:   A1WUL5
- SMR:   A1WUL5
- STRING:   A1WUL5
- GeneID:   4710565
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0591
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- PhylomeDB:   A1WUL5
- ProtClustDB:   PRK00093
- BioCyc:   HHAL349124:HHAL_0591-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 51578; Mature: 51447

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGM
CCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEECCCCEEEEECCCC
GEELEGVGGCMHEQARAAIAGADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKT
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECC
DGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFALLPPAEPDAVGSDGPGGIPV
CCCCCCCCHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRAR
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCCCEEEEEECCCHHHHHH
VQETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDG
HHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCHHHHHHHHHHHHCCCEEEEEEECCCC
LDPDQRRKVRRDLDLRFAFLGFARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
DALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGNQVQRLPRAYMRYLENFFRDT
HHHHHHHHCCCCCHHCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
FDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR
HHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGM
CCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEECCCCEEEEECCCC
GEELEGVGGCMHEQARAAIAGADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKT
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECC
DGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFALLPPAEPDAVGSDGPGGIPV
CCCCCCCCHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRAR
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCCCEEEEEECCCHHHHHH
VQETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDG
HHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCHHHHHHHHHHHHCCCEEEEEEECCCC
LDPDQRRKVRRDLDLRFAFLGFARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
DALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGNQVQRLPRAYMRYLENFFRDT
HHHHHHHHCCCCCHHCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
FDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR
HHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA