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The map label for this gene is moeB2 [H]

Identifier: 121639001

GI number: 121639001

Start: 3437262

End: 3438431

Strand: Direct

Name: moeB2 [H]

Synonym: BCG_3141

Alternate gene names: 121639001

Gene position: 3437262-3438431 (Clockwise)

Preceding gene: 121639000

Following gene: 121639002

Centisome position: 78.57

GC content: 58.46

Gene sequence:

>1170_bases
ATGACTGAAGCCTTGATCCCGGCACCGTCGCAGATATCGCTGACCCGCGATGAGGTGCGCAGGTACAGCAGGCACCTCAT
CATCCCGGATATCGGCGTCAACGGCCAACAGCGGCTGAAGGATGCGCGCGTATTGTGTATCGGCGCCGGAGGATTGGGTT
CGCCTGCTCTCCTGTATCTTGCGGCCGCCGGAGTCGGTACCATCGGCATCATCGATGGAGACCACGTGGATGAGTCGAAT
CTGCAACGCCAAATCATTCATGGCACATCCGACGTGGGTAGGCCGAAAGTAGAATCAGCAGCCGAGGCGGTGGCGGAAAT
CAACCCGCACGTCCGGGTGACGCAATATCGCGAAATGCTCACCCACGACAACGCACTGGAAATTTTTGGCGATCACGACC
TCATTGTTGACGGCACAGACAACTTCACGACGCGCTACCTGATCAATGATGCCGCGGTCTTGGCCGGCAAACCATATGTT
TGGGGGTCGATCTACCGATTCAACGGCCAGACCAGTGTGTTTTGGCCCGGCCGGGGGCCGTGTTATCGATGCCTTCATCC
AGCTCCGCCCCCGCCCGGATTGGTGCCGTCGTGCGCTGAAGGCGGTGTACTCGGTGCCATCTGCGCCACGATTGCGTCGA
TCCAGGTAACTGAAGTGCTGAAGCTCCTTACCGGAGTCGGAACTCCCCTCGTCGGTCGCCTGCTCATGTATGAAGCTCTC
GACGCGACATACCATCAAATCCGGATCGCGAAGAATCCTGACTGCGCCATTTGCGGCGATGCGCCCACGATCACCGAATT
GGTAGATGACAGCGTCAGCTGCGCATCGACACAATCGGTGGATCCCGAACTAGTGATCAGTTGTGATGAGTTGCGAACCA
AACAGCAGTCGGACCAGAACTTCCTCTTGGTCGACGTGCGAGAGCCCGCCGAGTTCGACATCGCGCACATTCCGGGCAGC
ATCTTGATACCCAAAGGCGAAATCGGCTCGGCGGCGGGCCTAGCCCAGCTACCGCTGGACAAGGAAATTGTCCTGTACTG
CAAGAGTGGAATCCGATCGGCCCAGGCGCTAACCACGTTGAAAGCAGCCGGACTGCACAACGTGAAGCATCTCGACGGCG
GTATCGCGGAGTGGACACGAACCATCGACTCCTCCTTGTTGGTGTACTAG

Upstream 100 bases:

>100_bases
ACACCCCAGCACTGACCACCTAGACTGCCACCCGAAGGATCACGCGAGGAACCTTCACTCGTACACCACGTCCCTGGCCT
TGGCCAGGAGGAGAGCAATC

Downstream 100 bases:

>100_bases
CACCGAACTATGCGAAAGGATTCCCGCCATGGCACGCTGCGATGTCCTGGTCTCCGCCGACTGGGCTGAGAGCAATCTGC
ACGCGCCGAAGGTCGTTTTC

Product: putative molybdenum cofactor biosynthesis protein moeB2

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESN
LQRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYV
WGSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEAL
DATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGS
ILIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY

Sequences:

>Translated_389_residues
MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESN
LQRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYV
WGSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEAL
DATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGS
ILIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY
>Mature_388_residues
TEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNL
QRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYVW
GSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALD
ATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSI
LIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=416, Percent_Identity=38.2211538461538, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4885649, Length=148, Percent_Identity=33.1081081081081, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI38045942, Length=181, Percent_Identity=34.2541436464088, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI38045944, Length=181, Percent_Identity=34.2541436464088, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI23510338, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI23510340, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38045948, Length=183, Percent_Identity=30.6010928961749, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=40.4858299595142, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87082356, Length=243, Percent_Identity=37.8600823045267, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789177, Length=111, Percent_Identity=36.036036036036, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=396, Percent_Identity=37.6262626262626, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI193203301, Length=164, Percent_Identity=28.0487804878049, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=180, Percent_Identity=32.2222222222222, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508819, Length=253, Percent_Identity=25.6916996047431, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=402, Percent_Identity=35.0746268656716, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6320598, Length=170, Percent_Identity=30, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322639, Length=270, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6325323, Length=169, Percent_Identity=28.9940828402367, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325438, Length=124, Percent_Identity=29.8387096774194, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582879, Length=391, Percent_Identity=42.1994884910486, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24660640, Length=150, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573937, Length=199, Percent_Identity=27.6381909547739, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129973, Length=171, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 41668; Mature: 41537

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYL
CCCCCCCCCCCEEECHHHHHHHHCEEEECCCCCCHHHHHCCCEEEEEECCCCCCHHHHHH
AAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREML
HHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHH
THDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYVWGSIYRFNGQTSVFWPGRGP
CCCCEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCCEEEEEEEECCCEEEEECCCCC
CYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEAL
CEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQN
HCCEEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCC
FLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTL
EEEEEECCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHH
KAAGLHNVKHLDGGIAEWTRTIDSSLLVY
HHHCCCCHHHHCCCHHHHHHHHCCCEECC
>Mature Secondary Structure 
TEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYL
CCCCCCCCCCEEECHHHHHHHHCEEEECCCCCCHHHHHCCCEEEEEECCCCCCHHHHHH
AAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREML
HHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHH
THDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYVWGSIYRFNGQTSVFWPGRGP
CCCCEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCCEEEEEEEECCCEEEEECCCCC
CYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEAL
CEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQN
HCCEEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCC
FLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTL
EEEEEECCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHH
KAAGLHNVKHLDGGIAEWTRTIDSSLLVY
HHHCCCCHHHHCCCHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]