BacMap

Definition	Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession	NC_008769
Length	4,374,522

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The map label for this gene is fabG [C]

Identifier: 121638970

GI number: 121638970

Start: 3405406

End: 3406236

Strand: Direct

Name: fabG [C]

Synonym: BCG_3110

Alternate gene names: 121638970

Gene position: 3405406-3406236 (Clockwise)

Preceding gene: 121638969

Following gene: 121638971

Centisome position: 77.85

GC content: 66.31

Gene sequence:

>831_bases
ATGAGCTCATTCGAAGGCAAGGTCGCCGTCATCACCGGGGCCGGCTCGGGCATCGGCAGAGCGTTGGCACTCAACCTCTC
CGAGAAGCGCGCAAAGCTTGCCCTTTCCGATGTCGACACCGACGGGCTGGCCAAAACCGTGCGCCTGGCTCAAGCGCTCG
GCGCGCAGGTGAAGTCGGACCGGCTCGACGTCGCCGAACGCGAGGCGGTGCTGGCCCACGCCGACGCCGTCGTCGCACAT
TTCGGCACCGTGCACCAGGTCTACAACAACGCCGGCATCGCGTACAACGGCAACGTCGACAAGTCGGAGTTCAAGGACAT
CGAGCGCATCATCGACGTCGACTTCTGGGGCGTCGTCAACGGCACCAAAGCCTTTCTGCCGCACGTGATTGCCTCCGGCG
ACGGACACATCGTCAACATCTCCAGCCTGTTCGGGCTGATCGCGGTGCCCGGGCAAAGCGCCTACAACGCGGCCAAGTTC
GCGGTGCGCGGCTTCACCGAGGCGCTGCGCCAGGAGATGCTGGTCGCCAGGCATCCGGTCAAGGTGACGTGCGTGCATCC
CGGCGGCATCAAAACCGCCGTCGCGCGCAACGCCACCGTGGCCGACGGCGAGGACCAGCAGACGTTCGCGGAGTTCTTCG
ACCGCCGGCTGGCGCTGCATTCGCCGGAGATGGCCGCCAAAACCATCGTCAACGGAGTCGCCAAGGGCCAGGCCCGCGTC
GTGGTCGGCCTGGAGGCCAAAGCCGTCGATGTGCTCGCGCGCATCATGGGCTCGTCGTATCAGCGGCTGGTTGCCGCCGG
CGTCGCCAAGTTCTTCCCCTGGGCCAAGTAG

Upstream 100 bases:

>100_bases
TCGGTCTGCTCCCCGAAGCCCGCGACGCGATCGCCGACCTCGGGGCAAGGCTGCGCGGCCACCTCCACCAATCGCAGGGA
CAACCACGGGGAGTAGTCAA

Downstream 100 bases:

>100_bases
GCCCATAGAGTTCTAGAAAGGGACACCACGATGAAAACCACCGCGGCGGTACTGTTCGAGGCGGGCAAACCGTTCGAGCT
GATGGAGCTCGATCTCGACG

Product: putative short-chain type dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFA [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSDRLDVAEREAVLAHADAVVAH
FGTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVNGTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKF
AVRGFTEALRQEMLVARHPVKVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARV
VVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK

Sequences:

>Translated_276_residues
MSSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSDRLDVAEREAVLAHADAVVAH
FGTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVNGTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKF
AVRGFTEALRQEMLVARHPVKVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARV
VVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK
>Mature_275_residues
SSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSDRLDVAEREAVLAHADAVVAHF
GTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVNGTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKFA
VRGFTEALRQEMLVARHPVKVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARVV
VGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=263, Percent_Identity=30.0380228136882, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI20149619, Length=203, Percent_Identity=35.4679802955665, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI40807363, Length=196, Percent_Identity=37.7551020408163, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI310128830, Length=278, Percent_Identity=32.3741007194245, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI310115468, Length=278, Percent_Identity=32.3741007194245, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI210032110, Length=198, Percent_Identity=29.2929292929293, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI25282469, Length=228, Percent_Identity=32.0175438596491, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7706318, Length=211, Percent_Identity=30.8056872037915, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI31542939, Length=218, Percent_Identity=30.7339449541284, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI44680136, Length=208, Percent_Identity=31.7307692307692, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI44680133, Length=208, Percent_Identity=31.7307692307692, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI17738292, Length=208, Percent_Identity=31.7307692307692, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI7657478, Length=248, Percent_Identity=30.241935483871, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI157739938, Length=279, Percent_Identity=26.5232974910394, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI40254992, Length=195, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI109715829, Length=208, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI224922801, Length=171, Percent_Identity=34.5029239766082, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI15277342, Length=198, Percent_Identity=31.8181818181818, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI150247226, Length=235, Percent_Identity=31.063829787234, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI32455239, Length=199, Percent_Identity=30.1507537688442, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI5031765, Length=199, Percent_Identity=30.1507537688442, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI223718074, Length=243, Percent_Identity=27.5720164609054, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4503817, Length=240, Percent_Identity=27.9166666666667, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI210032112, Length=198, Percent_Identity=26.2626262626263, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=223, Percent_Identity=29.5964125560538, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI22507405, Length=191, Percent_Identity=29.3193717277487, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI40548397, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI214010158, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI214010156, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI22758144, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI50726952, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=31.9587628865979, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=213, Percent_Identity=32.8638497652582, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789208, Length=217, Percent_Identity=31.7972350230415, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=31.0880829015544, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082160, Length=205, Percent_Identity=28.780487804878, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788459, Length=191, Percent_Identity=29.8429319371728, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.1208791208791, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=216, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=218, Percent_Identity=35.3211009174312, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17567345, Length=242, Percent_Identity=29.3388429752066, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193203115, Length=237, Percent_Identity=29.535864978903, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI193203117, Length=237, Percent_Identity=29.535864978903, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=218, Percent_Identity=33.9449541284404, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17564282, Length=198, Percent_Identity=28.2828282828283, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115534660, Length=243, Percent_Identity=26.7489711934156, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=196, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI32563809, Length=265, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=265, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=174, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=215, Percent_Identity=29.7674418604651, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=203, Percent_Identity=29.064039408867, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=175, Percent_Identity=32.5714285714286, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=201, Percent_Identity=29.3532338308458, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=224, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=221, Percent_Identity=28.0542986425339, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=240, Percent_Identity=25.8333333333333, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=200, Percent_Identity=28.5, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=222, Percent_Identity=27.4774774774775, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=226, Percent_Identity=27.4336283185841, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=202, Percent_Identity=29.7029702970297, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=217, Percent_Identity=26.7281105990783, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=32.6424870466321, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=28.6458333333333, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364892, Length=229, Percent_Identity=31.8777292576419, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358495, Length=275, Percent_Identity=29.4545454545455, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21355631, Length=169, Percent_Identity=34.3195266272189, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571526, Length=222, Percent_Identity=31.0810810810811, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24649181, Length=247, Percent_Identity=30.3643724696356, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644339, Length=223, Percent_Identity=29.1479820627803, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640492, Length=271, Percent_Identity=28.0442804428044, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357041, Length=222, Percent_Identity=30.1801801801802, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221510726, Length=181, Percent_Identity=35.3591160220994, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI23397609, Length=206, Percent_Identity=33.495145631068, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581726, Length=248, Percent_Identity=27.0161290322581, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221331218, Length=257, Percent_Identity=30.7392996108949, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24665243, Length=257, Percent_Identity=30.7392996108949, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24665247, Length=258, Percent_Identity=31.0077519379845, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221331216, Length=258, Percent_Identity=31.0077519379845, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356301, Length=260, Percent_Identity=25.7692307692308, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24580925, Length=209, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639444, Length=228, Percent_Identity=32.0175438596491, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281364494, Length=214, Percent_Identity=28.9719626168224, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648944, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI116007236, Length=210, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648693, Length=209, Percent_Identity=29.1866028708134, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355889, Length=209, Percent_Identity=29.1866028708134, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007234, Length=210, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644337, Length=225, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641388, Length=210, Percent_Identity=29.5238095238095, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18859837, Length=193, Percent_Identity=30.0518134715026, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28571387, Length=215, Percent_Identity=27.906976744186, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641232, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI116007238, Length=199, Percent_Identity=31.1557788944724, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29218; Mature: 29087

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00626 RCC1_2 ; PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSD
CCCCCCCEEEEEECCCCCCCEEEECCHHHHHHEEHHCCCCHHHHHHHHHHHHHCCHHCCC
RLDVAEREAVLAHADAVVAHFGTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHHCCCC
GTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKFAVRGFTEALRQEMLVARHPV
CHHHHHHHHHCCCCCCEEEHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
KVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARV
EEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
VVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK
EEECCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSD
CCCCCCEEEEEECCCCCCCEEEECCHHHHHHEEHHCCCCHHHHHHHHHHHHHCCHHCCC
RLDVAEREAVLAHADAVVAHFGTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHHCCCC
GTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKFAVRGFTEALRQEMLVARHPV
CHHHHHHHHHCCCCCCEEEHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
KVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARV
EEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
VVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK
EEECCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1905979; 11679669 [H]