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The map label for this gene is adhD [H]

Identifier: 121638971

GI number: 121638971

Start: 3406267

End: 3407373

Strand: Direct

Name: adhD [H]

Synonym: BCG_3111

Alternate gene names: 121638971

Gene position: 3406267-3407373 (Clockwise)

Preceding gene: 121638970

Following gene: 121638972

Centisome position: 77.87

GC content: 66.76

Gene sequence:

>1107_bases
ATGAAAACCACCGCGGCGGTACTGTTCGAGGCGGGCAAACCGTTCGAGCTGATGGAGCTCGATCTCGACGGGCCGGGTCC
GGGCGAGGTGTTGGTCAAATACACCGCCGCCGGGCTGTGCCATTCCGACCTGCACCTCACCGATGGTGATTTACCACCGC
GGTTCCCGATCGTGGGCGGCCACGAAGGGTCCGGGGTCATCGAGGAGGTGGGTGCCGGCGTCACCAGGGTCAAGCCCGGA
GACCACGTGGTGTGCAGCTTCATCCCGAACTGCGGGACTTGCCGCTACTGCTGCACCGGCCGGCAGAACCTGTGCGACAT
GGGGGCCACCATCCTGGAGGGCTGCATGCCGGACGGCAGTTTCCGATTCCATTCCCAGGGAACAGATTTCGGCGCCATGT
GCATGCTGGGCACGTTCGCCGAGCGGGCCACCGTCTCGCAGCATTCGGTGGTGAAGGTGGACGACTGGCTGCCACTGGAA
ACCGCGGTGCTGGTGGGCTGCGGCGTGCCGTCCGGTTGGGGCACCGCGGTCAATGCCGGAAACCTGCGGGCCGGCGACAC
CGCCGTCATCTACGGCGTCGGCGGCCTGGGCATCAACGCGGTCCAGGGCGCGACCGCCGCCGGCTGTAAGTACGTCGTGG
TGGTGGACCCGGTGGCTTTCAAGCGCGAGACCGCGCTCAAGTTCGGCGCCACCCATGCCTTCGCCGACGCCGCCAGCGCG
GCGGCCAAGGTCGACGAACTCACCTGGGGGCAGGGCGCCGACGCGGCGCTGATCCTGGTGGGCACCGTCGACGACGAGGT
GGTCTCGGCCGCGACCGCGGTGATCGGCAAGGGCGGCACCGTCGTCATCACCGGGCTGGCGGACCCGGCCAAACTCACCG
TGCACGTCTCCGGAACCGATTTGACGCTGCACGAGAAAACGATCAAGGGCTCGCTGTTCGGTTCCTGCAATCCGCAATAC
GACATCGTGCGGCTGCTGCGCCTCTACGACGCCGGCCAGCTGATGCTGGACGAACTCGTGACCACCACCTACAACCTCGA
ACAGGTGAACCAGGGCTACCAGGATCTGCGGGACGGCAAGAACATTCGGGGCGTGATCGTGCACTGA

Upstream 100 bases:

>100_bases
CATCATGGGCTCGTCGTATCAGCGGCTGGTTGCCGCCGGCGTCGCCAAGTTCTTCCCCTGGGCCAAGTAGGCCCATAGAG
TTCTAGAAAGGGACACCACG

Downstream 100 bases:

>100_bases
CCAGCTTCCACCAACCACGAATCCAGAGAGGACGATGATGCGCAGGCTCAACGGCGTTGACGCGCTGATGCTGTATCTCG
ACGGCGGCAGCGCCTACAAC

Product: putative zinc-type alcohol dehydrogenase adhD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPG
DHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLE
TAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQY
DIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH

Sequences:

>Translated_368_residues
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPG
DHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLE
TAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQY
DIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH
>Mature_368_residues
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPG
DHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLE
TAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQY
DIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=34.6774193548387, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=31.7934782608696, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=31.7934782608696, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=34.9462365591398, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=32.5268817204301, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=32.6145552560647, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=33.4231805929919, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=32.6027397260274, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=31.7460317460317, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI156627571, Length=355, Percent_Identity=25.0704225352113, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786552, Length=379, Percent_Identity=35.0923482849604, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=24.2165242165242, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=375, Percent_Identity=26.4, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87081918, Length=342, Percent_Identity=30.1169590643275, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=27.810650887574, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=366, Percent_Identity=26.5027322404372, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=370, Percent_Identity=25.4054054054054, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786518, Length=323, Percent_Identity=25.6965944272446, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=21.5258855585831, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=23.3236151603499, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=376, Percent_Identity=32.9787234042553, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997431, Length=378, Percent_Identity=32.8042328042328, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=32.4712643678161, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=30.3763440860215, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=374, Percent_Identity=31.5508021390374, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=371, Percent_Identity=29.6495956873315, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=363, Percent_Identity=26.1707988980716, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=379, Percent_Identity=23.7467018469657, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=33.9522546419098, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319257, Length=346, Percent_Identity=30.3468208092486, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=320, Percent_Identity=29.6875, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=296, Percent_Identity=30.0675675675676, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=318, Percent_Identity=27.3584905660377, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=366, Percent_Identity=25.9562841530055, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=289, Percent_Identity=28.0276816608997, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=26.6862170087977, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=34.4086021505376, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=25.3644314868805, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=24.3401759530792, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38342; Mature: 38342

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGG
CCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCEECCCEECCCCCCCCCCEECC
HEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGS
CCCCCHHHHHCCCEEEECCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
FRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCEECCC
NLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
CCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCHHHCHHHHHHHCCHHHHHHHHHH
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCE
LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGK
EEEEHHEECCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCC
NIRGVIVH
CCEEEEEC
>Mature Secondary Structure
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGG
CCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCEECCCEECCCCCCCCCCEECC
HEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGS
CCCCCHHHHHCCCEEEECCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
FRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCEECCC
NLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
CCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCHHHCHHHHHHHCCHHHHHHHHHH
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCE
LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGK
EEEEHHEECCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCC
NIRGVIVH
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]