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The map label for this gene is scoB

Identifier: 121638385

GI number: 121638385

Start: 2782267

End: 2782923

Strand: Reverse

Name: scoB

Synonym: BCG_2523c

Alternate gene names: 121638385

Gene position: 2782923-2782267 (Counterclockwise)

Preceding gene: 121638386

Following gene: 121638384

Centisome position: 63.62

GC content: 63.93

Gene sequence:

>657_bases
ATGAGCGCCCCGGGCTGGAGCCGAGACGAGATGGCCGCACGGGTGGCCGCGGAGTTCGAAGACGGTCAGTATGTCAACCT
TGGCATCGGCATGCCCACCCTGATTCCCAACCACATTCCCGACGGCGTCCATGTCGTCCTGCACTCGGAGAACGGCATCC
TCGGCGTCGGCCCCTACCCGCGGCGGGAGGACGTGGATGCCGATTTGATCAACGCGGGCAAGGAGACGGTCACCACGCTG
CCGGGTGCCGCATTCTTCAGCTCGTCGACTTCGTTCGGAATCATCCGCGGCGGCCACCTTGATGTCGCAGTGCTTGGCGC
GATGCAGGTTTCGGTCACCGGTGACCTAGCCAACTGGATGATCCCCGGCAAGATGGTCAAGGGCATGGGCGGCGCGATGG
ATCTGGTACACGGCGCTCGCAAGGTGATCGTGATGATGGAGCACACCGCCAAGGACGGTAGCCCCAAGATCCTAGAGCGG
TGCACATTGCCGTTGACCGGTGTGGGCTGCGTCGACCGCATTGTCACTGAACTCGCGGTCATCGATGTCTGCGCTGACGG
CCTGCACCTGGTCCAGACCGCTCCTGGCGTGTCGGTCGACGAGGTAGTCGCGAAGACTCAACCGCCCCTTGTGCTTCGGG
ACCTGGCGACCCAGTGA

Upstream 100 bases:

>100_bases
AGATCGACCCTGCCACCGTACACACCCCGGGCGTGTTTGTGCACCGGGTGGTTCATGTGCCCAACCCCGCCAAGAAGATC
GAGAGGGAGACGGTGCGGCA

Downstream 100 bases:

>100_bases
CCACCCCGTCGATAGCAATAGCCCCCTCGTTCGCCGACGAGCACCGCCGGCTGGTGGCGGAATTGAACAATAAGCTCGCC
GCCGCCGCCCTGGGCGGCAA

Product: putative succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta scoB

Products: NA

Alternate protein names: OXCT B; Succinyl CoA:3-oxoacid CoA-transferase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYPRREDVDADLINAGKETVTTL
PGAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWMIPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILER
CTLPLTGVGCVDRIVTELAVIDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ

Sequences:

>Translated_218_residues
MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYPRREDVDADLINAGKETVTTL
PGAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWMIPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILER
CTLPLTGVGCVDRIVTELAVIDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ
>Mature_217_residues
SAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYPRREDVDADLINAGKETVTTLP
GAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWMIPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILERC
TLPLTGVGCVDRIVTELAVIDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG2057

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit B family

Homologues:

Organism=Homo sapiens, GI4557817, Length=201, Percent_Identity=63.18407960199, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI11545841, Length=202, Percent_Identity=58.9108910891089, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1788552, Length=213, Percent_Identity=52.5821596244132, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17531517, Length=204, Percent_Identity=61.7647058823529, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21358325, Length=201, Percent_Identity=61.1940298507463, Blast_Score=256, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24655794, Length=201, Percent_Identity=61.1940298507463, Blast_Score=256, Evalue=9e-69,

Paralogues:

None

Copy number: 369 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): SCOB_MYCBO (P63651)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_856176.1
- ProteinModelPortal:   P63651
- SMR:   P63651
- EnsemblBacteria:   EBMYCT00000015322
- GeneID:   1090571
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2531c
- GeneTree:   EBGT00050000016110
- HOGENOM:   HBG353770
- OMA:   KLLTECT
- ProtClustDB:   CLSK791890
- BioCyc:   MBOV233413:MB2531C-MONOMER
- BRENDA:   2.8.3.5
- InterPro:   IPR012791
- InterPro:   IPR004165
- InterPro:   IPR004164
- PANTHER:   PTHR13707
- SMART:   SM00882
- TIGRFAMs:   TIGR02428

Pfam domain/function: PF01144 CoA_trans

EC number: =2.8.3.5

Molecular weight: Translated: 22899; Mature: 22768

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01274 COA_TRANSF_2

Important sites: ACT_SITE 50-50

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYP
CCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCCCEEEEEECCCCEEECCCCC
RREDVDADLINAGKETVTTLPGAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWM
CCCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEEECCCCCEEEEEEEEEEEECCHHHHC
IPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILERCTLPLTGVGCVDRIVTELAV
CCHHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
IDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ
HHHHHCCEEEECCCCCCCHHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure 
SAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYP
CCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCCCEEEEEECCCCEEECCCCC
RREDVDADLINAGKETVTTLPGAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWM
CCCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEEECCCCCEEEEEEEEEEEECCHHHHC
IPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILERCTLPLTGVGCVDRIVTELAV
CCHHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
IDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ
HHHHHCCEEEECCCCCCCHHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972