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The map label for this gene is accD1 [H]

Identifier: 121638384

GI number: 121638384

Start: 2780681

End: 2782270

Strand: Reverse

Name: accD1 [H]

Synonym: BCG_2522c

Alternate gene names: 121638384

Gene position: 2782270-2780681 (Counterclockwise)

Preceding gene: 121638385

Following gene: 121638383

Centisome position: 63.6

GC content: 65.66

Gene sequence:

>1590_bases
GTGACCACCCCGTCGATAGCAATAGCCCCCTCGTTCGCCGACGAGCACCGCCGGCTGGTGGCGGAATTGAACAATAAGCT
CGCCGCCGCCGCCCTGGGCGGCAACGAACGCGCCCGGAAACGCCACGTCAGCCGCGGCAAGCTGTTGCCCCGCGAACGGG
TGGACCGCCTGCTCGACCCGGGCAGCCCTTTCCTCGAGCTGGCTCCGCTGGCCGCTGGCGGCATGTACAGCGACGAATCC
CCGGGCGCGGGAATCATCACCGGGATCGGCCGGGTATCCGGACGCCAGTGCGTGATCGTCGCCAACGACGCGACGGTCAA
GGGCGGTACCTACTACCCGATGACGGTCAAGAAGCACCTGCGCGCCCAGGAGGTCGCGCTGCAGAATATGCTGCCGTGCA
TCTATCTGGTCGACTCCGGCGGCGCCTTCCTGCCCCGCCAAGACGAGGTGTTTCCCGACCGCGAGCATTTCGGGCGGATC
TTCTACAACCAGGCGACGATGAGCGCCAAGGGCATTCCGCAGGTGGCGGCGGTTCTCGGCTCCTGCACGGCGGGTGGCGC
TTATGTGCCGGCGATGAGTGACGAGGCCGTCATCGTCCGTGAGCAGGGCACGATCTTCCTCGGCGGTCCGCCACTGGTGA
AGGCGGCCACCGGCGAGATCGTCTCGGCCGAGGAACTTGGCGGTGGCGACTTGCACTCGCGCACGTCCGGTGTCACCGAC
CATCTGGCTGACGACGACGAGGACGCGCTGCGGATCGTGCGCGCGATCGCGGACACCTTCGGCCCGTGCGAACCCGCCCA
ATGGGATGTGCGCCGTTCGGTCGAGCCCAAGTACCCGCAGGCCGAGCTCTACGATGTGGTGCCCCCGGATCCCCGGGTCC
CTTACGACGTTCATGAGGTCGTCGTGCGGATTGTTGACGGCAGCGAATTCAGCGAGTTCAAGGCTAAATACGGCAAGACT
CTGGTGACTGCGTTTGCACGCGTCCACGGCCACCCGGTCGGGATCGTCGCCAACAACGGCGTGTTGTTAAGCGAATCCGC
GCTCAAGGGAGCGCATTTCATCGAGCTGTGCGACAAACGCAAGATTCCGCTGCTGTTCCTGCAGAACATCGCCGGCTTCA
TGGTCGGCCGCGACTACGAGGCCGGCGGAATCGCCAAGCATGGCGCCAAGATGGTCACCGCGGTGGCCTGCGCGCGGGTG
CCCAAGTTGACCGTGGTGATCGGCGGATCCTATGGTGCGGGTAACTATTCGATGTGCGGACGCGCGTACTCGCCCCGGTT
CCTGTGGATGTGGCCGAACGCGCGGATCTCGGTGATGGGCGGTGAGCAGGCCGCGTCCGTGTTGGCGACCGTGCGCGGCG
AGCAGCTGTCCGCGGCCGGCACACCCTGGTCACCCGACGAGGAGGAAGCGTTCAAGGCGCCCATCCGAGCGCAGTACGAA
GACCAGGGTAACCCCTACTATTCAACTGCCCGGCTGTGGGATGACGGTATCATAGACCCTGCGGACACCAGAACGGTTGT
TGGGCTTGCCCTTTCGTTGTGTGCCCACGCTCCGCTGGATCAGGTTGGCTACGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
CTGACGGCCTGCACCTGGTCCAGACCGCTCCTGGCGTGTCGGTCGACGAGGTAGTCGCGAAGACTCAACCGCCCCTTGTG
CTTCGGGACCTGGCGACCCA

Downstream 100 bases:

>100_bases
GGCGATGTTTGACACCGTACTAGTGGCCAACCGCGGTGAGATCGCGGTTCGGGTGATTCGGACGCTGCGCCGGCTAGGCA
TCCGGTCGGTCGCGGTCTAC

Product: putative acetyl-/propionyl-coa carboxylase subunit beta accD1

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDPGSPFLELAPLAAGGMYSDES
PGAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRI
FYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTSGVTD
HLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKT
LVTAFARVHGHPVGIVANNGVLLSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARV
PKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYE
DQGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM

Sequences:

>Translated_529_residues
MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDPGSPFLELAPLAAGGMYSDES
PGAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRI
FYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTSGVTD
HLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKT
LVTAFARVHGHPVGIVANNGVLLSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARV
PKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYE
DQGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM
>Mature_528_residues
TTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDPGSPFLELAPLAAGGMYSDESP
GAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRIF
YNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTSGVTDH
LADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTL
VTAFARVHGHPVGIVANNGVLLSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARVP
KLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYED
QGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=65.1162790697674, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=34.2465753424658, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=33.1450094161959, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI310133460, Length=126, Percent_Identity=63.4920634920635, Blast_Score=147, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17552936, Length=516, Percent_Identity=62.2093023255814, Blast_Score=673, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=33.9285714285714, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147362, Length=504, Percent_Identity=33.9285714285714, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=62.5468164794007, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56774; Mature: 56643

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDP
CCCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCC
GSPFLELAPLAAGGMYSDESPGAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHL
CCCCEEECCHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEECCCEECCHHHHHHH
RAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLG
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHCEEEEECHHCCCCCCHHHHHHHH
SCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTSGVTD
CCCCCCEECCCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCCCCCCCCCHH
HLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQAELYDVVPPDPRVPYDVHEV
HCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHH
VVRIVDGSEFSEFKAKYGKTLVTAFARVHGHPVGIVANNGVLLSESALKGAHFIELCDKR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCHHHHHHHCCC
KIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCC
RAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYE
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCC
DQGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHCC
>Mature Secondary Structure 
TTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDP
CCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCC
GSPFLELAPLAAGGMYSDESPGAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHL
CCCCEEECCHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEECCCEECCHHHHHHH
RAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLG
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHCEEEEECHHCCCCCCHHHHHHHH
SCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTSGVTD
CCCCCCEECCCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCCCCCCCCCHH
HLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQAELYDVVPPDPRVPYDVHEV
HCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHH
VVRIVDGSEFSEFKAKYGKTLVTAFARVHGHPVGIVANNGVLLSESALKGAHFIELCDKR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCHHHHHHHCCC
KIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCC
RAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYE
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCC
DQGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]