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The map label for this gene is rocD2 [H]

Identifier: 121638207

GI number: 121638207

Start: 2571249

End: 2571794

Strand: Reverse

Name: rocD2 [H]

Synonym: BCG_2342c

Alternate gene names: 121638207

Gene position: 2571794-2571249 (Counterclockwise)

Preceding gene: 121638208

Following gene: 121638206

Centisome position: 58.79

GC content: 64.65

Gene sequence:

>546_bases
ATGATCGCCGACGAAATCCAATCGGGGCTGGCCTGTACGGGTTACCCGTTCGCCTGCGACCACGGGGGTGTGCTGCCAGA
CATTTACCTGCTCGGCAAGACACTTGGTGGCGGTGCGGTTCCGTTGTCGGCGATGGTCGCGGACCGCGAAATCTTCGGCG
TGGTGCATCCCGGCGAACACGGGTCGACGTTCGGCGGCAATCCGTTGGCCGCCGCGATCGGTACCCCCGTGGTTTCCATG
GTCGTCTGGGGAGAATGTCAAGCTCGCTCCGCTAAATTGGGTGCGCATCTGCATCAGCGCCTGGCGGACCTGATCGGCGA
TGGTGCGGTGGCCCTGCGCGGCCTCGGATGGTGGGCTGACGTCGACATCGAACGGGCGCTTGCCATTGGCACAGACATGA
GCATGCGGTTGGCCGATCGCGGTGTGCTGTTAAAAGACACCTACGGCGCCGCCCTGCGGTTCGCGCCGCCGTTAGTGATC
ACCGCGCAGGAGATCGACTGCGCGGTTCGCCGGTTCGCCGACGCGCTATGGGAGGCGGGTTCATAA

Upstream 100 bases:

>100_bases
ACAACACCGTCGCTGACCTGCTCGAGCCGATTCCCGGCCAGGCGGGCATCATCGTCCCGGCCGACGACTACCTGCCGGCT
GCGTCGAGCACAACGTGCTG

Downstream 100 bases:

>100_bases
TTGCCGACAACGTCGATGAGCCTTCGAGAACTGATGCTGCGGCGCCGCCCGGTGAGCGGCGCCCCGGTCGCATCCGGGGC
ATCGGGGAACCTCAAGCGGA

Product: putative ornithine aminotransferase (C-terminus part) rocD2

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVVSM
VVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVI
TAQEIDCAVRRFADALWEAGS

Sequences:

>Translated_181_residues
MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVVSM
VVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVI
TAQEIDCAVRRFADALWEAGS
>Mature_181_residues
MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVVSM
VVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVI
TAQEIDCAVRRFADALWEAGS

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde. Controls arginine catabolism [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=171, Percent_Identity=40.9356725146199, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI284507298, Length=166, Percent_Identity=42.1686746987952, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI13994255, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1789759, Length=183, Percent_Identity=35.5191256830601, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI145693181, Length=183, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1787560, Length=188, Percent_Identity=36.1702127659575, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786991, Length=172, Percent_Identity=33.1395348837209, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1788044, Length=178, Percent_Identity=32.5842696629214, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1789016, Length=192, Percent_Identity=28.6458333333333, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=168, Percent_Identity=36.9047619047619, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=168, Percent_Identity=36.9047619047619, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=184, Percent_Identity=34.7826086956522, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=181, Percent_Identity=25.9668508287293, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357415, Length=164, Percent_Identity=37.8048780487805, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574759, Length=196, Percent_Identity=32.1428571428571, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161085790, Length=193, Percent_Identity=30.5699481865285, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 18881; Mature: 18881

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEH
CCHHHHHCCCEECCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCCCC
GSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWAD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCEEC
VDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWEAG
CCHHHHHHHCCCCEEEHHCCCEEEECCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHCCC
S
C
>Mature Secondary Structure
MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEH
CCHHHHHCCCEECCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCCCC
GSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWAD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCEEC
VDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWEAG
CCHHHHHHHCCCCEEEHHCCCEEEECCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377; 8113162 [H]