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The map label for this gene is pcoA [H]

Identifier: 121636769

GI number: 121636769

Start: 973186

End: 974700

Strand: Reverse

Name: pcoA [H]

Synonym: BCG_0898c

Alternate gene names: 121636769

Gene position: 974700-973186 (Counterclockwise)

Preceding gene: 121636774

Following gene: 121636767

Centisome position: 22.28

GC content: 64.82

Gene sequence:

>1515_bases
ATGCCCGAGCTGGCCACGAGCGGTAACGCCTTCGACAAGAGGCGGTTCAGCCGGCGCGGCTTCCTCGGCGCCGGCATCGC
CAGCGGCTTTGCGCTAGCCGCTTGCGCCTCGAAGCCCACGGCATCCGGCGCCGCCGGGATGACCGCTGCAATCGACGCGG
CCGAGGCGGCCCGGCCGCACAGTGGGCGAACGGTTACCGCCACGCTGACCCCCCAGCCGGCGAGGATCGACCTGGGTGGG
CCGATCGTCAGCACGCTGACCTACGGCAACACCATCCCCGGACCACTGATCCGGGCCACCGTCGGGGATGAGATTGTCGT
CTCGGTGACCAACCGTCTGGGTGATCCGACGTCGGTGCATTGGCACGGCATCGCGCTGCGCAACGATATGGATGGCACCG
AGCCCGCGACTGCGAACATCGGCCCCGGCGGTGACTTTACGTACCGGTTCTCCGTGCCGGATCCGGGCACCTACTGGGCC
CATCCGCACGTCGGTCTTCAAGGCGACCACGGCCTATATCTGCCTGTCGTCGTCGACGATCCGACTGAGCCAGGCCACTA
CGACGCCGAATGGATCATCATCCTCGACGATTGGACGGACGGCATCGGGAAGTCCCCGCAACAGCTCTACGGCGAGCTGA
CCGACCCGAACAAACCCACCATGCAAAACACAACAGGTATGCCCGAAGGCGAAGGCGTTGACAGCAACCTGCTCGGCGGC
GACGGAGGGGACATCGCCTACCCGTACTATCTGATCAACGGGCGAATCCCCGTGGCGGCCACGTCTTTTAAGGCCAAGCC
TGGCCAGCGAATCCGGATCCGCATCATCAACAGCGCCGCCGACACCGCGTTCCGCATCGCGCTGGCCGGGCATTCGATGA
CGGTCACCCACACCGACGGTTACCCAGTGATTCCCACCGAAGTCGACGCTCTGCTGATCGGCATGGCCGAACGCTACGAC
GTCATGGTGACCGCCGCTGGCGGCGTCTTTCCCCTGGTCGCACTCGCGGAAGGCAAGAACGCGCTGGCGCGTGCGCTGCT
GTCTACCGGCGCCGGCAGCCCACCCGACCCGCAGTTTCGGCCGGATGAACTCAACTGGCGAGTGGGTACCGTGGAAATGT
TCACCGCCGCAACGACTGCCAACCTGGGCCGGCCCGAACCCACCCACGACCTCCCGGTCACCTTGGGCGGCACCATGGCC
AAGTACGACTGGACAATCAACGGGGAACCCTACAGCACGACCAATCCACTGCACGTGCGGCTAGGCCAACGGCCAACCCT
GATGTTCGATAACACCACCATGATGTATCACCCAATCCACCTACACGGCCATACCTTTCAGATGATCAAGGCCGACGGCA
GCCCCGGCGCCCGCAAGGACACCGTGATAGTGCTGCCCAAGCAGAAGATGCGCGCCGTCCTGGTCGCCGACAATCCTGGC
GTGTGGGTGATGCACTGCCACAACAACTATCACCAGGTCGCCGGAATGGCGACCCGCCTGGACTACATTCTGTGA

Upstream 100 bases:

>100_bases
TAAGGGCGGATGATGGCGTGGTGATCATCAACCGTTGCGTACTGCCCGATGTCTGGGCAGGGTACGAAGAGCGAGACCAA
ATCCAGACGAGGAGCGATCG

Downstream 100 bases:

>100_bases
CAGGCGGCTTGTGGGCTGAACCGGGCCGCTGCCAGCGCCTCCCAGGACGTTGCCCGTGAGATGGCCCTGGACAGCCGGTT
GCGGACTGGCCGGCGTGACC

Product: putative oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGG
PIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWA
HPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGG
DGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYD
VMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMA
KYDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPG
VWVMHCHNNYHQVAGMATRLDYIL

Sequences:

>Translated_504_residues
MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGG
PIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWA
HPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGG
DGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYD
VMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMA
KYDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPG
VWVMHCHNNYHQVAGMATRLDYIL
>Mature_503_residues
PELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGGP
IVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWAH
PHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGGD
GGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYDV
MVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAK
YDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPGV
WVMHCHNNYHQVAGMATRLDYIL

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI17539950, Length=258, Percent_Identity=27.5193798449612, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=476, Percent_Identity=23.9495798319328, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321067, Length=496, Percent_Identity=23.7903225806452, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221330000, Length=254, Percent_Identity=31.8897637795276, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585842, Length=254, Percent_Identity=31.8897637795276, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221329998, Length=254, Percent_Identity=31.8897637795276, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI281360167, Length=254, Percent_Identity=31.8897637795276, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574104, Length=297, Percent_Identity=25.5892255892256, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53797; Mature: 53665

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPH
CCCCCCCCCCHHHHHHHHCCCEECCHHCCCEEEECCCCCCCCCCCCCEEEECHHHHCCCC
SGRTVTATLTPQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVH
CCCEEEEEECCCCCEEECCCCEEEEEECCCCCCCCEEEEECCCEEEEEEHHHCCCCCEEE
WHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWAHPHVGLQGDHGLYLPVVVDD
EEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCEEEEEEECC
PTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGG
CCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDG
CCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEECCC
YPVIPTEVDALLIGMAERYDVMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFR
CCCCCCCHHEEEEECCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
PDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAKYDWTINGEPYSTTNPLHVR
CCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCEEECCEEEEEEEEECCCCCCCCCCEEEE
LGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPG
ECCCCEEEECCCEEEEEEEEECCCEEEEEEECCCCCCCCCEEEEECHHHEEEEEEECCCC
VWVMHCHNNYHQVAGMATRLDYIL
EEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPH
CCCCCCCCCHHHHHHHHCCCEECCHHCCCEEEECCCCCCCCCCCCCEEEECHHHHCCCC
SGRTVTATLTPQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVH
CCCEEEEEECCCCCEEECCCCEEEEEECCCCCCCCEEEEECCCEEEEEEHHHCCCCCEEE
WHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWAHPHVGLQGDHGLYLPVVVDD
EEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCEEEEEEECC
PTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGG
CCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDG
CCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEECCC
YPVIPTEVDALLIGMAERYDVMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFR
CCCCCCCHHEEEEECCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
PDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAKYDWTINGEPYSTTNPLHVR
CCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCEEECCEEEEEEEEECCCCCCCCCCEEEE
LGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPG
ECCCCEEEECCCEEEEEEEEECCCEEEEEEECCCCCCCCCEEEEECHHHEEEEEEECCCC
VWVMHCHNNYHQVAGMATRLDYIL
EEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]