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The map label for this gene is pntB [H]

Identifier: 121611656

GI number: 121611656

Start: 5241279

End: 5242712

Strand: Direct

Name: pntB [H]

Synonym: Veis_4750

Alternate gene names: 121611656

Gene position: 5241279-5242712 (Clockwise)

Preceding gene: 121611655

Following gene: 121611657

Centisome position: 94.15

GC content: 65.62

Gene sequence:

>1434_bases
ATGAGCATGAACCTGGTCACGCTGCTGTATCTGGTCGCCAGCGTCTGCTTCATACAGGCCCTCAAGGGGCTGAGCCACCC
CACCACCTCGATCCGGGGCAACCTCTTCGGCATGGCCGGCATGGCCATTGCCATCCTGACCACGGCAGCGCTGATCGTGC
AATTGTCCGGGGCGTCCGCCGGCAAGACCCAGGGCATGGCCGCCTTGCTCACCGCCTTGCTGCTCGGCGGGGCCGCCGGC
GCGGTCATGGCCCACCGGGTCGAGATGACCAAGATGCCCGAATTGGTGGCCTTCATGCACAGCATGATCGGCCTGGCGGC
GGTGTTCATTGCCATCGCCGCCGTGGCCGAGCCCTGGGCCTTCCAGATCGTCGCCAAGGGCCAGCCGATACCGGCCGGCA
ACCGGCTCGAACTATTCCTCGGGGCGGCCATCGGCGCCATCACGTTCAGCGGCTCGGTGATCGCCTTCGGCAAGCTGTCG
GGCAAGTACCGGCTGCGGCTGTTCCAGGGCGCGCCGGTGCAGTTTGCCGGCCAGCACCTGCTGAACCTGGGGCTGGGCCT
GGCGACGCTGGGCCTGGGCCTGGGGTTCATGCTCACCGGCAACTGGGCGGCCTTTTTTGCGATGCTGGCGCTGTCGTTCG
TGCTCGGCCTGCTGATCATCATTCCGATTGGCGGCGCGGACATGCCGGTGGTGGTGTCCATGCTCAACAGCTACTCGGGC
TGGGCGGCGGCCGGCATCGGTTTTTCGCTGAACAATGCCATGCTGATCATTGCCGGCTCGCTGGTGGGCAGTTCCGGCGC
GATCCTGAGCTACATCATGTGCAAGGCCATGAACCGCTCGTTCTTCAACGTGATCCTGGGCGGCTTCGGCGGTGACGCAA
CGGCCGTCGCAGCGGCCGACCAGCGCCAGCGCAGCGTCAAAAGCGGCAGCGCCGACGATGTTGCCTTCGTGCTGGGCAAC
GCCGAAACCGTGGTCATCGTGCCGGGCTATGGCCTGGCCGTGGCGCGCGCCCAGCATGCCGTCAAGGAACTGGCGGCCAA
GCTCACCAGCAAGGGCGTGACCGTGAAATACGCGATCCACCCGGTGGCCGGCCGCATGCCAGGCCACATGAACGTGCTGC
TGGCCGAGGCCGAGGTGCCCTATGACCAGGTCTTCGAGATGGAAGACATCAACGGCGAATTCGGCCAGGCCGATGTCGCC
ATCATCCTGGGCGCCAACGACGTGGTGAACCCGGCCGCGCACACCAAGGGCAGCCCGATCTACGGCATGCCCATCCTGGA
AGCCTACCGGGCCAAGACCGTGATCGTGAACAAGCGCTCCATGGCGGCGGGCTATGCGGGCCTGGACAACGAGCTGTTCT
ACATGGACAAGACCATGATGGTCTTTGGCGACGCCAAGAAGGTGGTCGAGGACATCGGCAAGGCGATGGAGTGA

Upstream 100 bases:

>100_bases
CAGTCAACGTCTTCGGCGGCTTTCTGGTCACGCGGCGCATGTTGGCGATGTTCCGCAAGAAAGCCAAGCCGGCCGCGCCC
CAGGCCGAAGGAGGCCGGAC

Downstream 100 bases:

>100_bases
CCCGTTGCCGTTGTGCCGTTGCCGCCAGGCGCCGGAAAACGAGTCCAGGCCAGCGGAAACCCTGTTTGGATGATGGCCGC
CCGTCCCCTCCTGGATGATT

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSMNLVTLLYLVASVCFIQALKGLSHPTTSIRGNLFGMAGMAIAILTTAALIVQLSGASAGKTQGMAALLTALLLGGAAG
AVMAHRVEMTKMPELVAFMHSMIGLAAVFIAIAAVAEPWAFQIVAKGQPIPAGNRLELFLGAAIGAITFSGSVIAFGKLS
GKYRLRLFQGAPVQFAGQHLLNLGLGLATLGLGLGFMLTGNWAAFFAMLALSFVLGLLIIIPIGGADMPVVVSMLNSYSG
WAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGGDATAVAAADQRQRSVKSGSADDVAFVLGN
AETVVIVPGYGLAVARAQHAVKELAAKLTSKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMEDINGEFGQADVA
IILGANDVVNPAAHTKGSPIYGMPILEAYRAKTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVVEDIGKAME

Sequences:

>Translated_477_residues
MSMNLVTLLYLVASVCFIQALKGLSHPTTSIRGNLFGMAGMAIAILTTAALIVQLSGASAGKTQGMAALLTALLLGGAAG
AVMAHRVEMTKMPELVAFMHSMIGLAAVFIAIAAVAEPWAFQIVAKGQPIPAGNRLELFLGAAIGAITFSGSVIAFGKLS
GKYRLRLFQGAPVQFAGQHLLNLGLGLATLGLGLGFMLTGNWAAFFAMLALSFVLGLLIIIPIGGADMPVVVSMLNSYSG
WAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGGDATAVAAADQRQRSVKSGSADDVAFVLGN
AETVVIVPGYGLAVARAQHAVKELAAKLTSKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMEDINGEFGQADVA
IILGANDVVNPAAHTKGSPIYGMPILEAYRAKTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVVEDIGKAME
>Mature_476_residues
SMNLVTLLYLVASVCFIQALKGLSHPTTSIRGNLFGMAGMAIAILTTAALIVQLSGASAGKTQGMAALLTALLLGGAAGA
VMAHRVEMTKMPELVAFMHSMIGLAAVFIAIAAVAEPWAFQIVAKGQPIPAGNRLELFLGAAIGAITFSGSVIAFGKLSG
KYRLRLFQGAPVQFAGQHLLNLGLGLATLGLGLGFMLTGNWAAFFAMLALSFVLGLLIIIPIGGADMPVVVSMLNSYSGW
AAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGGDATAVAAADQRQRSVKSGSADDVAFVLGNA
ETVVIVPGYGLAVARAQHAVKELAAKLTSKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMEDINGEFGQADVAI
ILGANDVVNPAAHTKGSPIYGMPILEAYRAKTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVVEDIGKAME

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=482, Percent_Identity=44.3983402489627, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI122939153, Length=482, Percent_Identity=44.3983402489627, Blast_Score=363, Evalue=1e-100,
Organism=Escherichia coli, GI1787886, Length=482, Percent_Identity=49.792531120332, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17550456, Length=468, Percent_Identity=42.0940170940171, Blast_Score=332, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49512; Mature: 49381

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNLVTLLYLVASVCFIQALKGLSHPTTSIRGNLFGMAGMAIAILTTAALIVQLSGASA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHEECCCCC
GKTQGMAALLTALLLGGAAGAVMAHRVEMTKMPELVAFMHSMIGLAAVFIAIAAVAEPWA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FQIVAKGQPIPAGNRLELFLGAAIGAITFSGSVIAFGKLSGKYRLRLFQGAPVQFAGQHL
EEEEECCCCCCCCCCEEEEEHHHHHHEEECCCEEEEEECCCEEEEEEEECCCHHHHHHHH
LNLGLGLATLGLGLGFMLTGNWAAFFAMLALSFVLGLLIIIPIGGADMPVVVSMLNSYSG
HHHHHHHHHHHHCHHEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCC
WAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGGDATAVAAAD
CEEECCCEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEHHHH
QRQRSVKSGSADDVAFVLGNAETVVIVPGYGLAVARAQHAVKELAAKLTSKGVTVKYAIH
HHHHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
PVAGRMPGHMNVLLAEAEVPYDQVFEMEDINGEFGQADVAIILGANDVVNPAAHTKGSPI
ECCCCCCCCCEEEEEECCCCHHHHEEHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCE
YGMPILEAYRAKTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVVEDIGKAME
ECCHHHHHHCCEEEEEECCHHHCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
SMNLVTLLYLVASVCFIQALKGLSHPTTSIRGNLFGMAGMAIAILTTAALIVQLSGASA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHEECCCCC
GKTQGMAALLTALLLGGAAGAVMAHRVEMTKMPELVAFMHSMIGLAAVFIAIAAVAEPWA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FQIVAKGQPIPAGNRLELFLGAAIGAITFSGSVIAFGKLSGKYRLRLFQGAPVQFAGQHL
EEEEECCCCCCCCCCEEEEEHHHHHHEEECCCEEEEEECCCEEEEEEEECCCHHHHHHHH
LNLGLGLATLGLGLGFMLTGNWAAFFAMLALSFVLGLLIIIPIGGADMPVVVSMLNSYSG
HHHHHHHHHHHHCHHEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCC
WAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGGDATAVAAAD
CEEECCCEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEHHHH
QRQRSVKSGSADDVAFVLGNAETVVIVPGYGLAVARAQHAVKELAAKLTSKGVTVKYAIH
HHHHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
PVAGRMPGHMNVLLAEAEVPYDQVFEMEDINGEFGQADVAIILGANDVVNPAAHTKGSPI
ECCCCCCCCCEEEEEECCCCHHHHEEHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCE
YGMPILEAYRAKTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVVEDIGKAME
ECCHHHHHHCCEEEEEECCHHHCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]