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The map label for this gene is pntAA [H]

Identifier: 121611654

GI number: 121611654

Start: 5239763

End: 5240893

Strand: Direct

Name: pntAA [H]

Synonym: Veis_4748

Alternate gene names: 121611654

Gene position: 5239763-5240893 (Clockwise)

Preceding gene: 121611653

Following gene: 121611655

Centisome position: 94.13

GC content: 69.23

Gene sequence:

>1131_bases
ATGCTGATTGGTGTGCCGGCGGAATCCAGCGCAGGAGAGACCCGGGTCGCTGCGACGCCCGAAACCGTCAAAAAGCTCAA
GGCCCAGGGCCATACGCTGCGTATCGAATCAGGTGCCGGCACGGCGGCGAGCGTGCCCGATGCGGCTTATGCGGCGGCCG
GGGCCGAACTGTCCGATGCCGCAGGCGCCTGGGGCGCGGACCTGGTGCTGAAGGTGCGCAGCCCCTCGCCGGCCGAAACA
CCACGGCTGCGCGCTGGCGCCACGGTGGTGGGCATGCTCGATCCGCTCGATGCGGCGGGCCTGCAACGGCTGGCCGGCGC
GGGGGTGACGGCCTATGCGCTGGAAGCGGCCCCGCGCACCACGCGGGCGCAGAGCATGGACGTGCTGTCCTCGCAGGCCA
ATATCGCCGGCTACAAGGCCGTGATGATTGCCGCCGACCGTTACCAGCGCTTCTTCCCGATGCTGATGACGGCGGCCGGC
ACGGTCAAGGCCGCGCGCGTCGTCATCCTCGGCGTCGGCGTGGCGGGCCTGCAGGCCATTGCCACAGCCAAGCGCCTGGG
CGCCGTCATCGAGGCGTCCGACGTGCGGCCGAGCGTCAAGGAGCAGGTCGAATCGCTCGGCGGCAAGTTCATCGAGGTCT
CCTACGACACCGATGAAGAAAAGCAGGCCGCCGTCGGCGCCGGCGGCTATGCCAAGCCGATGCCGGCAAGCTGGCTCGCG
CGCCAGCAGGCCGAAGTCGCCAAGCGCGTCGCGCTCGCCGATGTCGTCATCGGCACCGCCCTCATTCCGGGCCGCGCCGC
GCCGACGCTCATCACCGCAGACATGGTCAAGTCCATGAAGCCGGGTTCGGTGATCGTCGACATCGCCGCCGGCAAGGGCC
CCGGCGGCGTGGGCGGCAACTGCCCGCTGTCGGAAGCCGACAAGACCGTGGTGCAACACGGCGTGACCATCGTTGGCGCG
ACCAACCTCGCGGCGCTGGTGGCAGCCGATGCCTCGGCGCTGTATGCGCGCAATGTGCTGGACTTTCTCAAACTCATCAT
CAACCGCGAAGGCGCGCTGCACATCGACCTGCAGGACGACATCGTTGCCGCCTGCCTGATGACGCACGAGGGTGCGGTCA
GGCGCGCATGA

Upstream 100 bases:

>100_bases
CCATGGGGCCACGGCCCGGCGCCGGCCAGGGCGGCAACCCCCGGGATTTCTTCAGGTAAGCTCGCGGCCAGCCATTTCAC
TGCCCCATCGAGGAGATCAC

Downstream 100 bases:

>100_bases
ACCGACGCCGGCGGTTGCCCCATGCAACCTGCGCGCCAGCAACGCTCAACGAAAGACCCCCGATGGACACCGTCTCTCCC
ACCCTGATCAACCTGATCAT

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MLIGVPAESSAGETRVAATPETVKKLKAQGHTLRIESGAGTAASVPDAAYAAAGAELSDAAGAWGADLVLKVRSPSPAET
PRLRAGATVVGMLDPLDAAGLQRLAGAGVTAYALEAAPRTTRAQSMDVLSSQANIAGYKAVMIAADRYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGGKFIEVSYDTDEEKQAAVGAGGYAKPMPASWLA
RQQAEVAKRVALADVVIGTALIPGRAAPTLITADMVKSMKPGSVIVDIAAGKGPGGVGGNCPLSEADKTVVQHGVTIVGA
TNLAALVAADASALYARNVLDFLKLIINREGALHIDLQDDIVAACLMTHEGAVRRA

Sequences:

>Translated_376_residues
MLIGVPAESSAGETRVAATPETVKKLKAQGHTLRIESGAGTAASVPDAAYAAAGAELSDAAGAWGADLVLKVRSPSPAET
PRLRAGATVVGMLDPLDAAGLQRLAGAGVTAYALEAAPRTTRAQSMDVLSSQANIAGYKAVMIAADRYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGGKFIEVSYDTDEEKQAAVGAGGYAKPMPASWLA
RQQAEVAKRVALADVVIGTALIPGRAAPTLITADMVKSMKPGSVIVDIAAGKGPGGVGGNCPLSEADKTVVQHGVTIVGA
TNLAALVAADASALYARNVLDFLKLIINREGALHIDLQDDIVAACLMTHEGAVRRA
>Mature_376_residues
MLIGVPAESSAGETRVAATPETVKKLKAQGHTLRIESGAGTAASVPDAAYAAAGAELSDAAGAWGADLVLKVRSPSPAET
PRLRAGATVVGMLDPLDAAGLQRLAGAGVTAYALEAAPRTTRAQSMDVLSSQANIAGYKAVMIAADRYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGGKFIEVSYDTDEEKQAAVGAGGYAKPMPASWLA
RQQAEVAKRVALADVVIGTALIPGRAAPTLITADMVKSMKPGSVIVDIAAGKGPGGVGGNCPLSEADKTVVQHGVTIVGA
TNLAALVAADASALYARNVLDFLKLIINREGALHIDLQDDIVAACLMTHEGAVRRA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=368, Percent_Identity=38.3152173913043, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI122939153, Length=368, Percent_Identity=38.3152173913043, Blast_Score=238, Evalue=9e-63,
Organism=Escherichia coli, GI1787887, Length=376, Percent_Identity=41.4893617021277, Blast_Score=277, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17550456, Length=373, Percent_Identity=39.142091152815, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38276; Mature: 38276

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGVPAESSAGETRVAATPETVKKLKAQGHTLRIESGAGTAASVPDAAYAAAGAELSDA
CEEECCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCHHH
AGAWGADLVLKVRSPSPAETPRLRAGATVVGMLDPLDAAGLQRLAGAGVTAYALEAAPRT
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCC
TRAQSMDVLSSQANIAGYKAVMIAADRYQRFFPMLMTAAGTVKAARVVILGVGVAGLQAI
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPSVKEQVESLGGKFIEVSYDTDEEKQAAVGAGGYAKPMPASWLA
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHH
RQQAEVAKRVALADVVIGTALIPGRAAPTLITADMVKSMKPGSVIVDIAAGKGPGGVGGN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHCCCCCCEEEEEECCCCCCCCCCC
CPLSEADKTVVQHGVTIVGATNLAALVAADASALYARNVLDFLKLIINREGALHIDLQDD
CCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHH
IVAACLMTHEGAVRRA
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLIGVPAESSAGETRVAATPETVKKLKAQGHTLRIESGAGTAASVPDAAYAAAGAELSDA
CEEECCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCHHH
AGAWGADLVLKVRSPSPAETPRLRAGATVVGMLDPLDAAGLQRLAGAGVTAYALEAAPRT
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCC
TRAQSMDVLSSQANIAGYKAVMIAADRYQRFFPMLMTAAGTVKAARVVILGVGVAGLQAI
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPSVKEQVESLGGKFIEVSYDTDEEKQAAVGAGGYAKPMPASWLA
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHH
RQQAEVAKRVALADVVIGTALIPGRAAPTLITADMVKSMKPGSVIVDIAAGKGPGGVGGN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHCCCCCCEEEEEECCCCCCCCCCC
CPLSEADKTVVQHGVTIVGATNLAALVAADASALYARNVLDFLKLIINREGALHIDLQDD
CCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHH
IVAACLMTHEGAVRRA
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]