Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 121611653

GI number: 121611653

Start: 5238590

End: 5239654

Strand: Direct

Name: fba [H]

Synonym: Veis_4747

Alternate gene names: 121611653

Gene position: 5238590-5239654 (Clockwise)

Preceding gene: 121611651

Following gene: 121611654

Centisome position: 94.11

GC content: 64.98

Gene sequence:

>1065_bases
ATGCCCCTCGTTTCGATGCGCGAACTGCTCGACCATGCTGCCAGCAACGGCTATGGCATTCCGGCCTTCAACGTCAACAA
CCTGGAACAGGTCCAGGCCGTGGTCGCCGCAGCCGATGAAGTCGGCGCCCCGGTGATCCTGCAAGCCAGCGCCGGTGCGC
GCAAATACGCTGGCGCGTCGTTCATCAAGCATCTGATCCTGGCCGCCGCCGAAGCCTATCCGCATATTCCGCTGGTGATG
CACCAGGACCATGGCGCATCGCCGCAGGTCTGCCAGGGCGCCATCGATCTGGGTTTTGGCTCGGTGATGATGGACGGCTC
GCTGCTGGAAGATGGCAAGACCCCGGCCACGTTTGAATACAACGTCGCCGTGACGCGCCAAGTGGTACAGATGGCGCACC
AGGTGGGCGTCACCGTCGAAGGCGAGCTCGGCTGCCTGGGCAACCTGGAAACCGGCGCTGCCGGCGAAGAAGACGGGGTC
GGCGCCGAAGGCCGGCTCGAGCGCAGCCAGATGCTGACCGACCCCGAGGAGGCGGCCAGCTTCGTCAAGGCCACCCAGCT
CGATGCGCTGGCAATTGCCATCGGCACCAGCCACGGCGCCTACAAATTCAGCCGCATCCCCAGCGCTGACATCCTGGCCA
TCGACCGCGTCAAGCAAATCCACCAGCGCATCCCCAACACCCATCTGGTGATGCACGGCTCCTCGTCGGTGCCGGCGCCG
CTGCTGGCCATCATCAACCAGTACGGCGGCAAGATCAAACAGACCTACGGCGTGCCGGTGGCGCAAATCCAGGAAGCCAT
ACGGCATGGCGTGCGCAAGATCAATATCGACACCGATATCCGCCTGGCGATGACCGGCGCGGTGCGCCAATTCCTGCACG
AAAACCCGGACAAATTCGATGCCCGCGAGTGGCTCAAGCCGGCCCGCGAAGCGGCCAAGGCGGTGTGCCGGCAGCGCTAC
ATCGATTTCGGCTGCGAAGGCCAGGGCGCCAGGATCAAGGGGCACAGCCTGCAAGCGGTGGCCGCCCAGTACGCTGCGGG
CACCTTGGCGCAGGTGGTGCACTGA

Upstream 100 bases:

>100_bases
CCCCCGGCTAGAATTGCCGGTTACCAACCGGTTACCACCAGCGCGGCTGGCCCGCAGCCCCTTTGCCGACCTTGTCCCGA
CCTTGAACGGAGTCTCGACC

Downstream 100 bases:

>100_bases
TTTCCGGGCCATGGGGCCACGGCCCGGCGCCGGCCAGGGCGGCAACCCCCGGGATTTCTTCAGGTAAGCTCGCGGCCAGC
CATTTCACTGCCCCATCGAG

Product: fructose-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRELLDHAASNGYGIPAFNVNNLEQVQAVVAAADEVGAPVILQASAGARKYAGASFIKHLILAAAEAYPHIPLVM
HQDHGASPQVCQGAIDLGFGSVMMDGSLLEDGKTPATFEYNVAVTRQVVQMAHQVGVTVEGELGCLGNLETGAAGEEDGV
GAEGRLERSQMLTDPEEAASFVKATQLDALAIAIGTSHGAYKFSRIPSADILAIDRVKQIHQRIPNTHLVMHGSSSVPAP
LLAIINQYGGKIKQTYGVPVAQIQEAIRHGVRKINIDTDIRLAMTGAVRQFLHENPDKFDAREWLKPAREAAKAVCRQRY
IDFGCEGQGARIKGHSLQAVAAQYAAGTLAQVVH

Sequences:

>Translated_354_residues
MPLVSMRELLDHAASNGYGIPAFNVNNLEQVQAVVAAADEVGAPVILQASAGARKYAGASFIKHLILAAAEAYPHIPLVM
HQDHGASPQVCQGAIDLGFGSVMMDGSLLEDGKTPATFEYNVAVTRQVVQMAHQVGVTVEGELGCLGNLETGAAGEEDGV
GAEGRLERSQMLTDPEEAASFVKATQLDALAIAIGTSHGAYKFSRIPSADILAIDRVKQIHQRIPNTHLVMHGSSSVPAP
LLAIINQYGGKIKQTYGVPVAQIQEAIRHGVRKINIDTDIRLAMTGAVRQFLHENPDKFDAREWLKPAREAAKAVCRQRY
IDFGCEGQGARIKGHSLQAVAAQYAAGTLAQVVH
>Mature_353_residues
PLVSMRELLDHAASNGYGIPAFNVNNLEQVQAVVAAADEVGAPVILQASAGARKYAGASFIKHLILAAAEAYPHIPLVMH
QDHGASPQVCQGAIDLGFGSVMMDGSLLEDGKTPATFEYNVAVTRQVVQMAHQVGVTVEGELGCLGNLETGAAGEEDGVG
AEGRLERSQMLTDPEEAASFVKATQLDALAIAIGTSHGAYKFSRIPSADILAIDRVKQIHQRIPNTHLVMHGSSSVPAPL
LAIINQYGGKIKQTYGVPVAQIQEAIRHGVRKINIDTDIRLAMTGAVRQFLHENPDKFDAREWLKPAREAAKAVCRQRYI
DFGCEGQGARIKGHSLQAVAAQYAAGTLAQVVH

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=34.3465045592705, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789526, Length=319, Percent_Identity=33.5423197492163, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788072, Length=333, Percent_Identity=30.6306306306306, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789293, Length=352, Percent_Identity=24.4318181818182, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=25.3561253561254, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37719; Mature: 37588

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00602 ALDOLASE_CLASS_II_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRELLDHAASNGYGIPAFNVNNLEQVQAVVAAADEVGAPVILQASAGARKYAGAS
CCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLILAAAEAYPHIPLVMHQDHGASPQVCQGAIDLGFGSVMMDGSLLEDGKTPATFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHCCCCHHCCCCCCCEEEE
NVAVTRQVVQMAHQVGVTVEGELGCLGNLETGAAGEEDGVGAEGRLERSQMLTDPEEAAS
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFSRIPSADILAIDRVKQIHQRIPNTHLVMHGSSSVPAP
HHHHHHHCEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LLAIINQYGGKIKQTYGVPVAQIQEAIRHGVRKINIDTDIRLAMTGAVRQFLHENPDKFD
HHHHHHHHCCCEEHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKAVCRQRYIDFGCEGQGARIKGHSLQAVAAQYAAGTLAQVVH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLVSMRELLDHAASNGYGIPAFNVNNLEQVQAVVAAADEVGAPVILQASAGARKYAGAS
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLILAAAEAYPHIPLVMHQDHGASPQVCQGAIDLGFGSVMMDGSLLEDGKTPATFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHCCCCHHCCCCCCCEEEE
NVAVTRQVVQMAHQVGVTVEGELGCLGNLETGAAGEEDGVGAEGRLERSQMLTDPEEAAS
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFSRIPSADILAIDRVKQIHQRIPNTHLVMHGSSSVPAP
HHHHHHHCEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LLAIINQYGGKIKQTYGVPVAQIQEAIRHGVRKINIDTDIRLAMTGAVRQFLHENPDKFD
HHHHHHHHCCCEEHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKAVCRQRYIDFGCEGQGARIKGHSLQAVAAQYAAGTLAQVVH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]