Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 121611488

GI number: 121611488

Start: 5069778

End: 5071139

Strand: Direct

Name: accC [H]

Synonym: Veis_4579

Alternate gene names: 121611488

Gene position: 5069778-5071139 (Clockwise)

Preceding gene: 121611487

Following gene: 121611489

Centisome position: 91.07

GC content: 69.16

Gene sequence:

>1362_bases
ATGAAGCCGGCCTTTGACACCTTGCTGGTCGCCAATCGCGGCGAGATCGCCGTGCGCATCATCCGCGCCGCGCGCGAGTT
GGGCCTCAGGACGGTGGCCGTTTTCAGCGATGCCGATGCGGGCAGCCTGCCGACCCGGCTGGCCGACCAGGCGGTGCCCA
TCGGCCCGGCGCAGGCGGGCAAGAGCTATCTGAATGTCGCGGCGCTCCTGAACGCGGCCCGGTCGGTCGGTGCGGGGGCA
ATCCATCCCGGCTACGGCTTCCTGTCGGAAAACGCCGCCTTCGCCGAAGCAGTCACTGCGGCCGGCCTGGTGTTTGTCGG
GCCTGGCGCCGCTGCGATCCGCACGATGGGCGACAAGGCGGCGGCCCGCCTGGCCGCGCAGCGCGCCGGCGTGGCGACCG
TGCCGGGCAGCGCCGGCGCGGTGGACGGGATCGAGGAGGCGCTCCGCATTGCCGGCGACATTGGCTACCCGGTGCTGATC
AAGGCCAGCGCGGGCGGCGGCGGGCGCGGCATCCACATCGCCGGCGATGCGAGCGAATTGCGCCAGGAACTGGGCCGGGC
GCAGGCGCAGGCCAAAGCGGCCTTCGGCGACGCTGCGGTCTACCTGGAGCGCTTCATCCGGCAGGCCCGGCATATCGAGG
TGCAGATCCTCGGCGACGGCAAGCGCGTCGTGCATTGCTTTGAGCGGGAATGCTCGTTGCAGCGCCGGCGCCAGAAAATC
TGGGAAGAAGCGCCATGCGCCGCCATTGACGCGGCGACGCGCCAGGCGCTGTGCGACAGCGCGCTCGCGCTGGCCCGCGC
GGTGGACTACAGCGGCGCCGGCACGCTGGAGTATTTGTACGACGAAGACACGCGCGCGTTTTTCTTCATCGAGATGAATA
CGCGCATACAGGTCGAGCATCCGGTCACGGAGATGGTGACCGGCGTCGATCTGGTCAAAGAAATGCTGCGCATCGCGCTC
GGCGAGCCACTGCGCTTGCAGCAAAGCGACATTGCCCTGCGCGGCGCCGCCATCGAGGTGCGCATCAATGCCGAGAACCC
GGCCAGAAACTTCATGCCCTGCCCGGGAACCTTGTCGTCGCTGCAAGTTCCGGGCGGCCCCGGCGTGCGCTTTGACAGCA
TGCTTTTTCCCGGCTGCCGGGTGCCGGCGTTTTACGACTCGCTGCTGGCCAAGTTGATCGTGCACGACGAGAACCGCCCG
GCCGCGCTCGCGCGCCTGGAGCGCGCGCTCGACGAACTGGGCACCGAAGGGCTGACGACCACGCAGGGCCTGCACCAAAA
GCTGGTGCGCGACCCGCAGGTGCGCGCCGGGCAATTGCACACCGGCTTCCTGGAAGCCTGGCTCGCCGCCCATCCGATGT
GA

Upstream 100 bases:

>100_bases
GGTGGACGGCGCCGTGCTGCGCTTTGCCGTCGGCAACGGCGATGCGGTGGAGCCGGGCCAGACGCTGCTGTTCATCGAAA
CCCCGTGAGCGCGCAAGACC

Downstream 100 bases:

>100_bases
AACCCCTTATCGCAGGATCAGGCCATGACCCCATCGACTCCATCGACTCCATCGACCCCCTCGACCCGATTGCCCCCGGC
CCGCTACACCTTCGGCGGTG

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKPAFDTLLVANRGEIAVRIIRAARELGLRTVAVFSDADAGSLPTRLADQAVPIGPAQAGKSYLNVAALLNAARSVGAGA
IHPGYGFLSENAAFAEAVTAAGLVFVGPGAAAIRTMGDKAAARLAAQRAGVATVPGSAGAVDGIEEALRIAGDIGYPVLI
KASAGGGGRGIHIAGDASELRQELGRAQAQAKAAFGDAAVYLERFIRQARHIEVQILGDGKRVVHCFERECSLQRRRQKI
WEEAPCAAIDAATRQALCDSALALARAVDYSGAGTLEYLYDEDTRAFFFIEMNTRIQVEHPVTEMVTGVDLVKEMLRIAL
GEPLRLQQSDIALRGAAIEVRINAENPARNFMPCPGTLSSLQVPGGPGVRFDSMLFPGCRVPAFYDSLLAKLIVHDENRP
AALARLERALDELGTEGLTTTQGLHQKLVRDPQVRAGQLHTGFLEAWLAAHPM

Sequences:

>Translated_453_residues
MKPAFDTLLVANRGEIAVRIIRAARELGLRTVAVFSDADAGSLPTRLADQAVPIGPAQAGKSYLNVAALLNAARSVGAGA
IHPGYGFLSENAAFAEAVTAAGLVFVGPGAAAIRTMGDKAAARLAAQRAGVATVPGSAGAVDGIEEALRIAGDIGYPVLI
KASAGGGGRGIHIAGDASELRQELGRAQAQAKAAFGDAAVYLERFIRQARHIEVQILGDGKRVVHCFERECSLQRRRQKI
WEEAPCAAIDAATRQALCDSALALARAVDYSGAGTLEYLYDEDTRAFFFIEMNTRIQVEHPVTEMVTGVDLVKEMLRIAL
GEPLRLQQSDIALRGAAIEVRINAENPARNFMPCPGTLSSLQVPGGPGVRFDSMLFPGCRVPAFYDSLLAKLIVHDENRP
AALARLERALDELGTEGLTTTQGLHQKLVRDPQVRAGQLHTGFLEAWLAAHPM
>Mature_453_residues
MKPAFDTLLVANRGEIAVRIIRAARELGLRTVAVFSDADAGSLPTRLADQAVPIGPAQAGKSYLNVAALLNAARSVGAGA
IHPGYGFLSENAAFAEAVTAAGLVFVGPGAAAIRTMGDKAAARLAAQRAGVATVPGSAGAVDGIEEALRIAGDIGYPVLI
KASAGGGGRGIHIAGDASELRQELGRAQAQAKAAFGDAAVYLERFIRQARHIEVQILGDGKRVVHCFERECSLQRRRQKI
WEEAPCAAIDAATRQALCDSALALARAVDYSGAGTLEYLYDEDTRAFFFIEMNTRIQVEHPVTEMVTGVDLVKEMLRIAL
GEPLRLQQSDIALRGAAIEVRINAENPARNFMPCPGTLSSLQVPGGPGVRFDSMLFPGCRVPAFYDSLLAKLIVHDENRP
AALARLERALDELGTEGLTTTQGLHQKLVRDPQVRAGQLHTGFLEAWLAAHPM

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=49.0990990990991, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=48.8789237668161, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=48.8789237668161, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=45.4545454545455, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=42.2818791946309, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=42.2818791946309, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=42.2818791946309, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=32.0158102766798, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=32.0158102766798, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=32.0158102766798, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=32.0158102766798, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=32.0158102766798, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=31.8897637795276, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=48.8789237668161, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1786216, Length=247, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=43.9461883408072, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=45.7858769931663, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=454, Percent_Identity=41.6299559471366, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=28.1188118811881, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=27.4028629856851, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=479, Percent_Identity=28.6012526096033, Blast_Score=184, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=43.018018018018, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=40.4444444444444, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=40.6666666666667, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=30.873786407767, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=436, Percent_Identity=30.5045871559633, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651757, Length=440, Percent_Identity=45.4545454545455, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652210, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652214, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19921944, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652216, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI281363050, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652224, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652222, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652220, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24652218, Length=455, Percent_Identity=42.4175824175824, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=43.4567901234568, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=32.2709163346614, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=32.2709163346614, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=32.2709163346614, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=32.2709163346614, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48081; Mature: 48081

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAFDTLLVANRGEIAVRIIRAARELGLRTVAVFSDADAGSLPTRLADQAVPIGPAQAG
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCCHHHH
KSYLNVAALLNAARSVGAGAIHPGYGFLSENAAFAEAVTAAGLVFVGPGAAAIRTMGDKA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHH
AARLAAQRAGVATVPGSAGAVDGIEEALRIAGDIGYPVLIKASAGGGGRGIHIAGDASEL
HHHHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCHHHH
RQELGRAQAQAKAAFGDAAVYLERFIRQARHIEVQILGDGKRVVHCFERECSLQRRRQKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
WEEAPCAAIDAATRQALCDSALALARAVDYSGAGTLEYLYDEDTRAFFFIEMNTRIQVEH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEECC
PVTEMVTGVDLVKEMLRIALGEPLRLQQSDIALRGAAIEVRINAENPARNFMPCPGTLSS
CHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCCCC
LQVPGGPGVRFDSMLFPGCRVPAFYDSLLAKLIVHDENRPAALARLERALDELGTEGLTT
EECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCH
TQGLHQKLVRDPQVRAGQLHTGFLEAWLAAHPM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPAFDTLLVANRGEIAVRIIRAARELGLRTVAVFSDADAGSLPTRLADQAVPIGPAQAG
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCCHHHH
KSYLNVAALLNAARSVGAGAIHPGYGFLSENAAFAEAVTAAGLVFVGPGAAAIRTMGDKA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHH
AARLAAQRAGVATVPGSAGAVDGIEEALRIAGDIGYPVLIKASAGGGGRGIHIAGDASEL
HHHHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCHHHH
RQELGRAQAQAKAAFGDAAVYLERFIRQARHIEVQILGDGKRVVHCFERECSLQRRRQKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
WEEAPCAAIDAATRQALCDSALALARAVDYSGAGTLEYLYDEDTRAFFFIEMNTRIQVEH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEECC
PVTEMVTGVDLVKEMLRIALGEPLRLQQSDIALRGAAIEVRINAENPARNFMPCPGTLSS
CHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCCCC
LQVPGGPGVRFDSMLFPGCRVPAFYDSLLAKLIVHDENRPAALARLERALDELGTEGLTT
EECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCH
TQGLHQKLVRDPQVRAGQLHTGFLEAWLAAHPM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]