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The map label for this gene is mraY

Identifier: 121611476

GI number: 121611476

Start: 5056131

End: 5057309

Strand: Direct

Name: mraY

Synonym: Veis_4567

Alternate gene names: 121611476

Gene position: 5056131-5057309 (Clockwise)

Preceding gene: 121611475

Following gene: 121611477

Centisome position: 90.83

GC content: 63.95

Gene sequence:

>1179_bases
ATGATGCTGCTGCTGGCGCAATGGTTGCAGGGCATGTCGTCCGAACTCGGCTTCTTGCGCGTGTTCCAGTACCTGACCAT
GCGCGCCGTGCTGGCCGCACTGACGGCGCTGCTGATCGGCCTGGCGGCAGGCTCCTGGGTGATCGGCAAACTGATGGCGC
TGAAGATCGGCCAGCCGATTCGCGGCTACGCGCCGCAGTCGCACCTGTCCAAGAGCGGCACGCCGACCATGGGCGGGGTG
CTGATCTTGCTGTCGATTGCGCTGTCGACCCTGCTGTGGTTCGACCTGTCCAACCGCTTCGTCTGGATCGTGCTGCTGGT
CACGCTCGGCTTTGGCGCCATCGGCTGGGTCGACGACTGGCGCAAGGTGGTCGACAAAAACCCCGAGGGCATGCGCTCGC
GCGAGAAGTATCTCTGGCAATCGCTGATCGGGCTGATGGCGGCGCTGTACCTGGTGTTTTGCATCTCGGAGAACTCCAAC
GCCAAGGTGCTGGAACTGTTCATCAGTTGGATGCGCTCGGGCTTCGCGCTCGATCTGCCGCCCAAGGCCGGCTTGCAACT
GCCGTTTTTCAAGGCCGTGAGCTACCCGCTGGGGGTGCTCGGCTTCGTGCTGCTGACCTACCTGGTGATCGTCGGTTCGA
GCAATGCCGTGAACCTGACCGACGGGCTCGACGGACTGGCCATCATGCCGGTGGTGATGGTCGGCTCGGCCCTGGGGGTG
TTTGCCTATGTCACCGGCAGCGCGGTGTATTCCCGCTACCTGTTCTTCCCGCATATCCCCGGCTCGGGCGAGTTGCTGAT
CTTTTGCGCCGCGATGGCCGGCGCCGGCCTGGCCTTTCTGTGGTTCAACGCGCATCCGGCGCAGGTGTTCATGGGCGATG
TCGGCGCGCTGGCCTTGGGCGCCGCGCTGGGCACCATCGCCATCATCGTGCGCCAGGAGATCGTGCTGGCCGTGATGGGC
GGCATCTTTGTCGCCGAGGCGCTGTCGGTGATGCTGCAGGTGGGCTGGTTCAAGTACACCCGGTACCGCTACGGCGAGGG
CCGGCGCCTGCTCAAAATGGCGCCGCTGCACCACCATTTCGAAAAAAGCGGCTGGAAGGAAACGCAGGTGGTGGTGCGCT
TTTGGATCATCACCATGCTGCTGTGCCTGGTGGGCCTGTCGACATTGAAGCTGCGATGA

Upstream 100 bases:

>100_bases
TGCGCCAGGCCCTGCCCGATGTCGGCAGCGTGCTGGTCAAAGGCTCCCGGAGCATGAGGATGGAGCAGGTGCTCAAAGAG
ATACAGGCCGGGGGTGGCGC

Downstream 100 bases:

>100_bases
ATCCGAACGCCCAGCCCACCCTGCCCGCCCGGCCTCTGGATGAGGCCGGGGCGCCCGTGCCCGAGGCCCCCCCCGGGGCA
CCCCGCGTAAAACCCCCGGT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MMLLLAQWLQGMSSELGFLRVFQYLTMRAVLAALTALLIGLAAGSWVIGKLMALKIGQPIRGYAPQSHLSKSGTPTMGGV
LILLSIALSTLLWFDLSNRFVWIVLLVTLGFGAIGWVDDWRKVVDKNPEGMRSREKYLWQSLIGLMAALYLVFCISENSN
AKVLELFISWMRSGFALDLPPKAGLQLPFFKAVSYPLGVLGFVLLTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGSALGV
FAYVTGSAVYSRYLFFPHIPGSGELLIFCAAMAGAGLAFLWFNAHPAQVFMGDVGALALGAALGTIAIIVRQEIVLAVMG
GIFVAEALSVMLQVGWFKYTRYRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSTLKLR

Sequences:

>Translated_392_residues
MMLLLAQWLQGMSSELGFLRVFQYLTMRAVLAALTALLIGLAAGSWVIGKLMALKIGQPIRGYAPQSHLSKSGTPTMGGV
LILLSIALSTLLWFDLSNRFVWIVLLVTLGFGAIGWVDDWRKVVDKNPEGMRSREKYLWQSLIGLMAALYLVFCISENSN
AKVLELFISWMRSGFALDLPPKAGLQLPFFKAVSYPLGVLGFVLLTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGSALGV
FAYVTGSAVYSRYLFFPHIPGSGELLIFCAAMAGAGLAFLWFNAHPAQVFMGDVGALALGAALGTIAIIVRQEIVLAVMG
GIFVAEALSVMLQVGWFKYTRYRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSTLKLR
>Mature_392_residues
MMLLLAQWLQGMSSELGFLRVFQYLTMRAVLAALTALLIGLAAGSWVIGKLMALKIGQPIRGYAPQSHLSKSGTPTMGGV
LILLSIALSTLLWFDLSNRFVWIVLLVTLGFGAIGWVDDWRKVVDKNPEGMRSREKYLWQSLIGLMAALYLVFCISENSN
AKVLELFISWMRSGFALDLPPKAGLQLPFFKAVSYPLGVLGFVLLTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGSALGV
FAYVTGSAVYSRYLFFPHIPGSGELLIFCAAMAGAGLAFLWFNAHPAQVFMGDVGALALGAALGTIAIIVRQEIVLAVMG
GIFVAEALSVMLQVGWFKYTRYRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=374, Percent_Identity=50.2673796791444, Blast_Score=344, Evalue=6e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_VEREI (A1WRK8)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999283.1
- STRING:   A1WRK8
- GeneID:   4694625
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4567
- NMPDR:   fig|391735.5.peg.4187
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   WITREPE
- PhylomeDB:   A1WRK8
- ProtClustDB:   PRK00108
- BioCyc:   VEIS391735:VEIS_4567-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 42906; Mature: 42906

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x120a45dc)-; HASH(0x11ea1294)-; HASH(0xfcf92e8)-; HASH(0xfd050ac)-; HASH(0x120f3754)-; HASH(0x1272032c)-; HASH(0x125318b8)-; HASH(0x1127d4a0)-; HASH(0x125df5fc)-; HASH(0x127b8dc8)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCH
>Mature Secondary Structure
MMLLLAQWLQGMSSELGFLRVFQYLTMRAVLAALTALLIGLAAGSWVIGKLMALKIGQPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
RGYAPQSHLSKSGTPTMGGVLILLSIALSTLLWFDLSNRFVWIVLLVTLGFGAIGWVDDW
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHH
RKVVDKNPEGMRSREKYLWQSLIGLMAALYLVFCISENSNAKVLELFISWMRSGFALDLP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECC
PKAGLQLPFFKAVSYPLGVLGFVLLTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGSALGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHH
FAYVTGSAVYSRYLFFPHIPGSGELLIFCAAMAGAGLAFLWFNAHPAQVFMGDVGALALG
HHHHHHHHHHHHHHEECCCCCCCCCEEHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
AALGTIAIIVRQEIVLAVMGGIFVAEALSVMLQVGWFKYTRYRYGEGRRLLKMAPLHHHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
EKSGWKETQVVVRFWIITMLLCLVGLSTLKLR
HHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA