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The map label for this gene is appB [H]

Identifier: 121611206

GI number: 121611206

Start: 4734321

End: 4735337

Strand: Direct

Name: appB [H]

Synonym: Veis_4291

Alternate gene names: 121611206

Gene position: 4734321-4735337 (Clockwise)

Preceding gene: 121611205

Following gene: 121611207

Centisome position: 85.05

GC content: 69.22

Gene sequence:

>1017_bases
GTGAGGGGCGGCGCCGTGGCCCTGACAGGTCTGTCCGGTATGCCGGGCATGTTGCGCCACACCGCCGCGCGGCTGCTGCA
GGCCGCCGGCCTGGTGCTCGCGGTGGTGGTGCTGAACTTCGTGCTGGTGCACGCCGCGCCGGGCGACCCGGTGGAAACCA
TCGCCGGCGCCAGCGGCGGCATGTCGCCCGAGCTGATGGCGCAGTTGCGCCAGCAGTACGGGCTCGACCAGCCGCTGCCG
GTGCAGTTGTGGGTCTACCTGGGCAAGGTGGTCCAGGGTGATCTGGGCCACTCGTATTTCTTCAACCAGCCGGTGGCGCA
GATGATCGCCGCCCGCGTGCCGGCCACGCTGCTGCTGATGCTCAGCGCGGTGTCGCTGGCCTTCGGGGTGGGCACCGCGC
TGGGCGTGCTGTCCGCGCGCAAGCCCAATGGCTGGCTGTCGCAGTTCATCACCGTGCTGTCGCTGGTGGGCTTTGCGGCG
CCGGTGTTCTGGCTCGGGATCATGCTGGTGATCCTGCTGGCCTCGGTGCTGCCGATCTTGCCGGTGGCCGGCATGCGTTC
GATCGACGCCAGCGGCGGCGGGATCGGGGATGTGCTCGACGTGGCCCACCACCTGGTGCTGCCGACGCTCACGCTCAGCC
TGGTGTACCTGGCGCAGTACAGCCGGCTCGCGCGCTCGGCCATGCTCGACGTGCTGGGCGCGGACTTCATCCGCACCGCG
CGCGCCAAGGGCCTGGCCGAGCGCGTGGTGCTCTACAGGCACGCATTGCGCAATGCGCTGCTGCCGGTGGTCACGGTGCT
GGGGCTGCAATTTGGCAACATGCTGGCCGGCGCGATTCTGGTCGAGACGGTGTTCAACTGGCCGGGCCTGGGCCGGCTGG
CCTTCGAGTCGGTGCTGCGGCGCGACTACCCGACCATCCTGGGCGTGCTGCTGTTCTCCTCCATCGTGGTGGTGGCGATG
AACCAGATCACCGATCTGTGCTACCGCCTCATCGACCCGCGGATCAAGGCACCATGA

Upstream 100 bases:

>100_bases
TCAACCAGGTGCCCTACCACACCATCACCAGCAAGAAGCTGGCGCAGGTGCCGACCTCGATCTGGGGGCCGATGTCGCCG
CTGGACGAGGTCTACTACAA

Downstream 100 bases:

>100_bases
GCGCAGCCCGGCCGCCCGAAGGCGCTCATACCGCAGCGCTGCCTGCCCCCGTCGTCCATGTCGAGCACCCGGGCGTCGAG
GCGTTGCGCATGTTCCTGCG

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRGGAVALTGLSGMPGMLRHTAARLLQAAGLVLAVVVLNFVLVHAAPGDPVETIAGASGGMSPELMAQLRQQYGLDQPLP
VQLWVYLGKVVQGDLGHSYFFNQPVAQMIAARVPATLLLMLSAVSLAFGVGTALGVLSARKPNGWLSQFITVLSLVGFAA
PVFWLGIMLVILLASVLPILPVAGMRSIDASGGGIGDVLDVAHHLVLPTLTLSLVYLAQYSRLARSAMLDVLGADFIRTA
RAKGLAERVVLYRHALRNALLPVVTVLGLQFGNMLAGAILVETVFNWPGLGRLAFESVLRRDYPTILGVLLFSSIVVVAM
NQITDLCYRLIDPRIKAP

Sequences:

>Translated_338_residues
MRGGAVALTGLSGMPGMLRHTAARLLQAAGLVLAVVVLNFVLVHAAPGDPVETIAGASGGMSPELMAQLRQQYGLDQPLP
VQLWVYLGKVVQGDLGHSYFFNQPVAQMIAARVPATLLLMLSAVSLAFGVGTALGVLSARKPNGWLSQFITVLSLVGFAA
PVFWLGIMLVILLASVLPILPVAGMRSIDASGGGIGDVLDVAHHLVLPTLTLSLVYLAQYSRLARSAMLDVLGADFIRTA
RAKGLAERVVLYRHALRNALLPVVTVLGLQFGNMLAGAILVETVFNWPGLGRLAFESVLRRDYPTILGVLLFSSIVVVAM
NQITDLCYRLIDPRIKAP
>Mature_338_residues
MRGGAVALTGLSGMPGMLRHTAARLLQAAGLVLAVVVLNFVLVHAAPGDPVETIAGASGGMSPELMAQLRQQYGLDQPLP
VQLWVYLGKVVQGDLGHSYFFNQPVAQMIAARVPATLLLMLSAVSLAFGVGTALGVLSARKPNGWLSQFITVLSLVGFAA
PVFWLGIMLVILLASVLPILPVAGMRSIDASGGGIGDVLDVAHHLVLPTLTLSLVYLAQYSRLARSAMLDVLGADFIRTA
RAKGLAERVVLYRHALRNALLPVVTVLGLQFGNMLAGAILVETVFNWPGLGRLAFESVLRRDYPTILGVLLFSSIVVVAM
NQITDLCYRLIDPRIKAP

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=337, Percent_Identity=41.2462908011869, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1787053, Length=320, Percent_Identity=40.3125, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1787761, Length=327, Percent_Identity=40.6727828746177, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787497, Length=321, Percent_Identity=32.398753894081, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789888, Length=321, Percent_Identity=33.9563862928349, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788504, Length=357, Percent_Identity=28.2913165266106, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1787550, Length=269, Percent_Identity=32.7137546468402, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35886; Mature: 35886

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGAVALTGLSGMPGMLRHTAARLLQAAGLVLAVVVLNFVLVHAAPGDPVETIAGASGG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
MSPELMAQLRQQYGLDQPLPVQLWVYLGKVVQGDLGHSYFFNQPVAQMIAARVPATLLLM
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHH
LSAVSLAFGVGTALGVLSARKPNGWLSQFITVLSLVGFAAPVFWLGIMLVILLASVLPIL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVAGMRSIDASGGGIGDVLDVAHHLVLPTLTLSLVYLAQYSRLARSAMLDVLGADFIRTA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKGLAERVVLYRHALRNALLPVVTVLGLQFGNMLAGAILVETVFNWPGLGRLAFESVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RDYPTILGVLLFSSIVVVAMNQITDLCYRLIDPRIKAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRGGAVALTGLSGMPGMLRHTAARLLQAAGLVLAVVVLNFVLVHAAPGDPVETIAGASGG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
MSPELMAQLRQQYGLDQPLPVQLWVYLGKVVQGDLGHSYFFNQPVAQMIAARVPATLLLM
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHH
LSAVSLAFGVGTALGVLSARKPNGWLSQFITVLSLVGFAAPVFWLGIMLVILLASVLPIL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVAGMRSIDASGGGIGDVLDVAHHLVLPTLTLSLVYLAQYSRLARSAMLDVLGADFIRTA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKGLAERVVLYRHALRNALLPVVTVLGLQFGNMLAGAILVETVFNWPGLGRLAFESVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RDYPTILGVLLFSSIVVVAMNQITDLCYRLIDPRIKAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]