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The map label for this gene is paaE [H]

Identifier: 121610867

GI number: 121610867

Start: 4333529

End: 4334614

Strand: Direct

Name: paaE [H]

Synonym: Veis_3949

Alternate gene names: 121610867

Gene position: 4333529-4334614 (Clockwise)

Preceding gene: 121610866

Following gene: 121610868

Centisome position: 77.85

GC content: 69.06

Gene sequence:

>1086_bases
ATGAGCCCCATCTTCCACCCCCTGCGCGTGCGCTCCATCGAGCCTGACACGGCCGAAGCCGTCATCGTCGCCTTCGATGT
GCCGCCGGATCTGCACCAGGTGTTCGGGTTCACCCAGGGCCAGCACCTGACGCTGCGCGCCGACATCGACGGCCAGGACC
TGCGCCGCGCCTACTCCATCTGCGCCGGCATCGACGATGGCCAACTGCGCGTGGGCGTGCGCAAGGTCGCCGGTGGCCGG
TTCTCCCACTGGCTCCATACCCGGCTGCGGGTCGGTGATACCTTGCAGGTGATGGCGCCGCAGGGCCGCTTCTTCGTGCC
GCTGCAGCCCGCCGCGCAGCGCCACTACCTGGGCATCGCGGGGGGCAGCGGCATCACGCCCATCCTGTCGCTCATGAAGA
CGGCGCTGGCGCGCGAGCCGCGCAGCCGCTTTACGCTGATCTACGGCAACCGCAGCCTGCAGTCCACCATGTTCAGGGAA
GAACTGCAGGACCTGAAGAACCGCTACCTGGCGCGCCTGGCGCTGCACCATGTGTTCTCGGCCGAACAGACCGATCTGCC
GCTGAACATGGGCCGGATCGACCACGGCAAGATCACGGCCTTCCTGGATGCGCTGCTGCCCGTGCGCCGCATCGATGTGG
CCTTCATCTGCGGCCCCTTCCAGATGAACGACCAGGTGCAGGCCGCGCTACTGGCCGCCGGCCTGCCGGCCGAGCGCATC
CATGTCGAGCGCTTTGGTCTGGCGCTGCCCGCCGGCGCTCAGGCCGATGCCGTCATGCACCAGGCGCTGGCGGGCGACGC
GCACAGCGCGCGCATCACCATCGTGCGCGACGGCCTGCGGCGCGAGTTCCGCTTCACCCGGGAGCAGGCCAGCATTCTGG
ATGCGGCCTCGGCGGCCGGGCTGGAATTGCCGTTTGCCTGCACCTCGGGCGTGTGCGGAACCTGTCGCGCCCGATGCCTG
CAAGGCCGGGTGCGCATGGAGCGCAATTTCGCGCTCGACCAGGCCGATCTGGACGCCGGCTTCGTGCTCAGTTGCCAATG
CCGGCCGCTGACGGACAGCGTCGTGCTGTCGTTCGACGAGCGCTGA

Upstream 100 bases:

>100_bases
TCGGCGCCACGGCCTGCAAGGCGCTGTACCGGTGCCTGGACTGCCGCGAGCCCTTCGAGCATTTCAAGCCCTTGTAAAGC
GCCCTTTTTTCGTCACCGAC

Downstream 100 bases:

>100_bases
TGATGGCCGCCAGCGTGGCGCCCGGCCGTTTCTCCGCACCAAGGCGCGCTGCCTGCATGCCGGCCGCGCCCCGCGATGAG
GCAAGATGGCGCCCCCGATA

Product: phenylacetate-CoA oxygenase/reductase, PaaK subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSPIFHPLRVRSIEPDTAEAVIVAFDVPPDLHQVFGFTQGQHLTLRADIDGQDLRRAYSICAGIDDGQLRVGVRKVAGGR
FSHWLHTRLRVGDTLQVMAPQGRFFVPLQPAAQRHYLGIAGGSGITPILSLMKTALAREPRSRFTLIYGNRSLQSTMFRE
ELQDLKNRYLARLALHHVFSAEQTDLPLNMGRIDHGKITAFLDALLPVRRIDVAFICGPFQMNDQVQAALLAAGLPAERI
HVERFGLALPAGAQADAVMHQALAGDAHSARITIVRDGLRREFRFTREQASILDAASAAGLELPFACTSGVCGTCRARCL
QGRVRMERNFALDQADLDAGFVLSCQCRPLTDSVVLSFDER

Sequences:

>Translated_361_residues
MSPIFHPLRVRSIEPDTAEAVIVAFDVPPDLHQVFGFTQGQHLTLRADIDGQDLRRAYSICAGIDDGQLRVGVRKVAGGR
FSHWLHTRLRVGDTLQVMAPQGRFFVPLQPAAQRHYLGIAGGSGITPILSLMKTALAREPRSRFTLIYGNRSLQSTMFRE
ELQDLKNRYLARLALHHVFSAEQTDLPLNMGRIDHGKITAFLDALLPVRRIDVAFICGPFQMNDQVQAALLAAGLPAERI
HVERFGLALPAGAQADAVMHQALAGDAHSARITIVRDGLRREFRFTREQASILDAASAAGLELPFACTSGVCGTCRARCL
QGRVRMERNFALDQADLDAGFVLSCQCRPLTDSVVLSFDER
>Mature_360_residues
SPIFHPLRVRSIEPDTAEAVIVAFDVPPDLHQVFGFTQGQHLTLRADIDGQDLRRAYSICAGIDDGQLRVGVRKVAGGRF
SHWLHTRLRVGDTLQVMAPQGRFFVPLQPAAQRHYLGIAGGSGITPILSLMKTALAREPRSRFTLIYGNRSLQSTMFREE
LQDLKNRYLARLALHHVFSAEQTDLPLNMGRIDHGKITAFLDALLPVRRIDVAFICGPFQMNDQVQAALLAAGLPAERIH
VERFGLALPAGAQADAVMHQALAGDAHSARITIVRDGLRREFRFTREQASILDAASAAGLELPFACTSGVCGTCRARCLQ
GRVRMERNFALDQADLDAGFVLSCQCRPLTDSVVLSFDER

Specific function: May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI284448551, Length=269, Percent_Identity=27.5092936802974, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI284448553, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI6552328, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI193794826, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4503327, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI49574502, Length=221, Percent_Identity=28.0542986425339, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787658, Length=357, Percent_Identity=45.6582633053221, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1787098, Length=326, Percent_Identity=23.9263803680982, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788104, Length=358, Percent_Identity=25.9776536312849, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788903, Length=239, Percent_Identity=25.5230125523013, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17563926, Length=220, Percent_Identity=25.9090909090909, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17563928, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322146, Length=214, Percent_Identity=26.6355140186916, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323510, Length=187, Percent_Identity=26.7379679144385, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281366101, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662934, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662938, Length=221, Percent_Identity=26.6968325791855, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR011884
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 39787; Mature: 39656

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIFHPLRVRSIEPDTAEAVIVAFDVPPDLHQVFGFTQGQHLTLRADIDGQDLRRAYSI
CCCCCCCCEEECCCCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
CAGIDDGQLRVGVRKVAGGRFSHWLHTRLRVGDTLQVMAPQGRFFVPLQPAAQRHYLGIA
HCCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCEEEEE
GGSGITPILSLMKTALAREPRSRFTLIYGNRSLQSTMFREELQDLKNRYLARLALHHVFS
CCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEQTDLPLNMGRIDHGKITAFLDALLPVRRIDVAFICGPFQMNDQVQAALLAAGLPAERI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCHHHE
HVERFGLALPAGAQADAVMHQALAGDAHSARITIVRDGLRREFRFTREQASILDAASAAG
EHHHHCEECCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
LELPFACTSGVCGTCRARCLQGRVRMERNFALDQADLDAGFVLSCQCRPLTDSVVLSFDE
CCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEECC
R
C
>Mature Secondary Structure 
SPIFHPLRVRSIEPDTAEAVIVAFDVPPDLHQVFGFTQGQHLTLRADIDGQDLRRAYSI
CCCCCCCEEECCCCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
CAGIDDGQLRVGVRKVAGGRFSHWLHTRLRVGDTLQVMAPQGRFFVPLQPAAQRHYLGIA
HCCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCEEEEE
GGSGITPILSLMKTALAREPRSRFTLIYGNRSLQSTMFREELQDLKNRYLARLALHHVFS
CCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEQTDLPLNMGRIDHGKITAFLDALLPVRRIDVAFICGPFQMNDQVQAALLAAGLPAERI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCHHHE
HVERFGLALPAGAQADAVMHQALAGDAHSARITIVRDGLRREFRFTREQASILDAASAAG
EHHHHCEECCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
LELPFACTSGVCGTCRARCLQGRVRMERNFALDQADLDAGFVLSCQCRPLTDSVVLSFDE
CCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEECC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]