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The map label for this gene is pepA [H]

Identifier: 120611821

GI number: 120611821

Start: 3490912

End: 3492498

Strand: Reverse

Name: pepA [H]

Synonym: Aave_3162

Alternate gene names: 120611821

Gene position: 3492498-3490912 (Counterclockwise)

Preceding gene: 120611827

Following gene: 120611820

Centisome position: 65.25

GC content: 73.72

Gene sequence:

>1587_bases
ATGAACTTCGATCTGAAGACCCTGTCCCTGGCCTCCGCCGCCGCCGAGAAATGCGATTTGCTCGCCGTGCTGGTGCCCGA
AGGCTTCAAGCCCGGCGGCGACGCGATTTCCGCCCTGGTGGCGCTGGCGATCCGCCAGGGAGACTTCGAACCCAAGCCCG
GCAAGAGCCTCGCGCTCTACCAGGCACCCGCCGTGGCCGCGCGGCGCGTGCTGCTCCTGGGCGCAGGCGACGGCGGCGCG
CGCGCGGTGCGCCAGGCGCTGGCCGGTGCGGCAGCGCACTGGAAGGCGCCCCAGGTCAAGCGCGCGGCCGTGTGCCTCGC
GGCCCTGGCCGACGGCGGCGCGGCGGCCTGCACGGCCGTGCAGGCCGTGGCGGAGTCCAGCTATGTCTACACGGCCACCA
AGTCCCAGGCCGAACCGCGGGCGCTCTCGCGCGTGGTGATCGGCGTGGCCGATGCCGCCGCCGCCAGGGCCGGTTTCGCC
CGCGGCACGGCGCTGGCGCTGGGCATCGAATACGCCCGCGAATGGGCCAACCGCCCCGGCAACCACGCCACGCCCACCCT
GCTGGCCGGCGCCGCCAAGGCGCTCGCCAAGCACGGCCCCATCCAGGTCAAGGTGATGGGGCCCGCGGAAGTGCAGAAGC
TCGGCATGGGCGCCTTCATGGCGGTGGCCAGGGGCTCCGAGGAGCCCCTGCGCTTCATCGAGCTGCGCTACCAGGGCGCG
GGCCGCTCCGAGGCGCCCGTGGCGCTCATCGGCAAGGGCATCACCTTCGACACCGGCGGCATCTCGATCAAGCCCGCCGG
CGAAATGGACGAGATGAAGTTCGACATGGGCGGCGCCGCCAGCGTGCTGGGCGTGTTCCGCGCGCTCGCCGAACTGCGGC
CCGCCATCAACGTGGTCGGCCTGATTCCCGCCTGCGAGAACATGCCCGACGGCCGCGCTGTGAAGCCGGGCGACGTCGTC
ACCAGCCTCAGCGGCCAGACGATCGAGGTGCTCAACACCGACGCGGAAGGCCGGCTGGTGCTGTGCGATGCGATCGCGTA
TGCCGCGCGCTTCAAGCCCTCCGCCATGGTGGACATCGCGACGCTCACGGGCGCCTGCGTGATCGCGCTCGGCGGGGTGC
GCAGCGGCCTGTTCGCCAACGACGAGGCCCTGGCCACGCGCCTGCAGCAGGCGGGCGAATCCGCGATGGACCCGTGCTGG
CGCATGCCGCTCGACGACGAGTACGCCGAAGGCCTGAAGAGCAATTTCGCCGACATGGGCAACGTGGCCGGCCGCGCCGC
CGGCGCCGTCACGGCCGCCAAGTTCCTGCAGAAGTTCGTGGGCACGCAGCCCTGGGCCCACCTGGACATCGCCGGCACGG
CCTGGAAGAGCGGCGGCGGCAAGGGCGCTACGGGCCGCCCCGTTGGCCTGCTCGTGCAGTTCCTGCTCGACTCCGTGCAG
GCGCCCGCTGCCCGCCCGCGTTCCCGCACGGCGGGCGCAGCCGCGGCACCGGCGCCCGTTTCGGCACCGGCAGCGGCACC
CGCCGCCGGCCGTACCCGGCGTGTCGCGGCGCCTGCCCGCCCCGCCCGGGCTGCGCGCACCGCGTGA

Upstream 100 bases:

>100_bases
ACCACGGTGACCAGCACCACCAGCGTCGCGCCGAAGCTGCGGGCCAGTTCCTTGCGAATGGATGAATCGAATAACATTGG
CTCGAAGGAAAACGCCGATT

Downstream 100 bases:

>100_bases
TCGCGCAGGCTGCATTCCGCTCGATGGCGCCCGTGCCCGCATGACCGAGATCGCCTTCCATTTCAATGCGCCGGACAAGC
TCGCCTATGCGTGCCGCTTC

Product: PepA aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MNFDLKTLSLASAAAEKCDLLAVLVPEGFKPGGDAISALVALAIRQGDFEPKPGKSLALYQAPAVAARRVLLLGAGDGGA
RAVRQALAGAAAHWKAPQVKRAAVCLAALADGGAAACTAVQAVAESSYVYTATKSQAEPRALSRVVIGVADAAAARAGFA
RGTALALGIEYAREWANRPGNHATPTLLAGAAKALAKHGPIQVKVMGPAEVQKLGMGAFMAVARGSEEPLRFIELRYQGA
GRSEAPVALIGKGITFDTGGISIKPAGEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGRAVKPGDVV
TSLSGQTIEVLNTDAEGRLVLCDAIAYAARFKPSAMVDIATLTGACVIALGGVRSGLFANDEALATRLQQAGESAMDPCW
RMPLDDEYAEGLKSNFADMGNVAGRAAGAVTAAKFLQKFVGTQPWAHLDIAGTAWKSGGGKGATGRPVGLLVQFLLDSVQ
APAARPRSRTAGAAAAPAPVSAPAAAPAAGRTRRVAAPARPARAARTA

Sequences:

>Translated_528_residues
MNFDLKTLSLASAAAEKCDLLAVLVPEGFKPGGDAISALVALAIRQGDFEPKPGKSLALYQAPAVAARRVLLLGAGDGGA
RAVRQALAGAAAHWKAPQVKRAAVCLAALADGGAAACTAVQAVAESSYVYTATKSQAEPRALSRVVIGVADAAAARAGFA
RGTALALGIEYAREWANRPGNHATPTLLAGAAKALAKHGPIQVKVMGPAEVQKLGMGAFMAVARGSEEPLRFIELRYQGA
GRSEAPVALIGKGITFDTGGISIKPAGEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGRAVKPGDVV
TSLSGQTIEVLNTDAEGRLVLCDAIAYAARFKPSAMVDIATLTGACVIALGGVRSGLFANDEALATRLQQAGESAMDPCW
RMPLDDEYAEGLKSNFADMGNVAGRAAGAVTAAKFLQKFVGTQPWAHLDIAGTAWKSGGGKGATGRPVGLLVQFLLDSVQ
APAARPRSRTAGAAAAPAPVSAPAAAPAAGRTRRVAAPARPARAARTA
>Mature_528_residues
MNFDLKTLSLASAAAEKCDLLAVLVPEGFKPGGDAISALVALAIRQGDFEPKPGKSLALYQAPAVAARRVLLLGAGDGGA
RAVRQALAGAAAHWKAPQVKRAAVCLAALADGGAAACTAVQAVAESSYVYTATKSQAEPRALSRVVIGVADAAAARAGFA
RGTALALGIEYAREWANRPGNHATPTLLAGAAKALAKHGPIQVKVMGPAEVQKLGMGAFMAVARGSEEPLRFIELRYQGA
GRSEAPVALIGKGITFDTGGISIKPAGEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGRAVKPGDVV
TSLSGQTIEVLNTDAEGRLVLCDAIAYAARFKPSAMVDIATLTGACVIALGGVRSGLFANDEALATRLQQAGESAMDPCW
RMPLDDEYAEGLKSNFADMGNVAGRAAGAVTAAKFLQKFVGTQPWAHLDIAGTAWKSGGGKGATGRPVGLLVQFLLDSVQ
APAARPRSRTAGAAAAPAPVSAPAAAPAAGRTRRVAAPARPARAARTA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=373, Percent_Identity=42.0911528150134, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI47155554, Length=318, Percent_Identity=31.4465408805031, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1790710, Length=493, Percent_Identity=43.8133874239351, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=40.3125, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=295, Percent_Identity=34.9152542372881, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=287, Percent_Identity=31.3588850174216, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355725, Length=340, Percent_Identity=37.3529411764706, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24661038, Length=340, Percent_Identity=37.0588235294118, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129969, Length=329, Percent_Identity=37.6899696048632, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24662227, Length=379, Percent_Identity=33.245382585752, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI161077148, Length=330, Percent_Identity=34.8484848484849, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20130057, Length=330, Percent_Identity=34.8484848484849, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21355645, Length=328, Percent_Identity=35.9756097560976, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24662223, Length=328, Percent_Identity=35.9756097560976, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI19922386, Length=384, Percent_Identity=32.5520833333333, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129963, Length=382, Percent_Identity=31.151832460733, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI221379063, Length=307, Percent_Identity=33.8762214983713, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221379062, Length=307, Percent_Identity=33.8762214983713, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21357381, Length=307, Percent_Identity=33.8762214983713, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646701, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646703, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358201, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53707; Mature: 53707

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDLKTLSLASAAAEKCDLLAVLVPEGFKPGGDAISALVALAIRQGDFEPKPGKSLALY
CCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEE
QAPAVAARRVLLLGAGDGGARAVRQALAGAAAHWKAPQVKRAAVCLAALADGGAAACTAV
ECCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
QAVAESSYVYTATKSQAEPRALSRVVIGVADAAAARAGFARGTALALGIEYAREWANRPG
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NHATPTLLAGAAKALAKHGPIQVKVMGPAEVQKLGMGAFMAVARGSEEPLRFIELRYQGA
CCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHCCHHHHHHHCCCCCCEEEEEEEECCC
GRSEAPVALIGKGITFDTGGISIKPAGEMDEMKFDMGGAASVLGVFRALAELRPAINVVG
CCCCCCEEEEECCEEECCCCEEECCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHEE
LIPACENMPDGRAVKPGDVVTSLSGQTIEVLNTDAEGRLVLCDAIAYAARFKPSAMVDIA
ECCCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCHHEEHH
TLTGACVIALGGVRSGLFANDEALATRLQQAGESAMDPCWRMPLDDEYAEGLKSNFADMG
HHHHHHHEEECCHHCCCCCCHHHHHHHHHHHCHHHCCHHHCCCCCHHHHHHHHHHHHHHH
NVAGRAAGAVTAAKFLQKFVGTQPWAHLDIAGTAWKSGGGKGATGRPVGLLVQFLLDSVQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
APAARPRSRTAGAAAAPAPVSAPAAAPAAGRTRRVAAPARPARAARTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MNFDLKTLSLASAAAEKCDLLAVLVPEGFKPGGDAISALVALAIRQGDFEPKPGKSLALY
CCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEE
QAPAVAARRVLLLGAGDGGARAVRQALAGAAAHWKAPQVKRAAVCLAALADGGAAACTAV
ECCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
QAVAESSYVYTATKSQAEPRALSRVVIGVADAAAARAGFARGTALALGIEYAREWANRPG
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NHATPTLLAGAAKALAKHGPIQVKVMGPAEVQKLGMGAFMAVARGSEEPLRFIELRYQGA
CCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHCCHHHHHHHCCCCCCEEEEEEEECCC
GRSEAPVALIGKGITFDTGGISIKPAGEMDEMKFDMGGAASVLGVFRALAELRPAINVVG
CCCCCCEEEEECCEEECCCCEEECCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHEE
LIPACENMPDGRAVKPGDVVTSLSGQTIEVLNTDAEGRLVLCDAIAYAARFKPSAMVDIA
ECCCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCHHEEHH
TLTGACVIALGGVRSGLFANDEALATRLQQAGESAMDPCWRMPLDDEYAEGLKSNFADMG
HHHHHHHEEECCHHCCCCCCHHHHHHHHHHHCHHHCCHHHCCCCCHHHHHHHHHHHHHHH
NVAGRAAGAVTAAKFLQKFVGTQPWAHLDIAGTAWKSGGGKGATGRPVGLLVQFLLDSVQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
APAARPRSRTAGAAAAPAPVSAPAAAPAAGRTRRVAAPARPARAARTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA