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The map label for this gene is glyA

Identifier: 120611655

GI number: 120611655

Start: 3298554

End: 3299798

Strand: Direct

Name: glyA

Synonym: Aave_2992

Alternate gene names: 120611655

Gene position: 3298554-3299798 (Clockwise)

Preceding gene: 120611654

Following gene: 120611656

Centisome position: 61.62

GC content: 64.82

Gene sequence:

>1245_bases
ATGTACCAACGCAATATTCTTGTCGAACAAGCCGATCCCGAAGTGTGGGCCGCCATCCAGGCCGAGAACCTGCGCCAGGA
GCAGCACATCGAACTGATCGCCAGCGAGAACTACGCCTCGCCCGCCGTCATGGCGGCACAGGGCTCGCAGCTCACCAACA
AGTACGCCGAAGGCTATCCCGGCAAGCGCTACTACGGCGGCTGCGAGAACGTGGACGTGGTCGAGCAGCTGGCCATCGAC
CGCGTGAAGAAGCTCTTCGGCGCCGATGCCGCCAACGTGCAGCCCAATTCCGGCTCGCAGGCCAACCAGGCCGTGCTGCT
TGCCTTCCTCAAGCCCGGCGACACCATCCTGGGCATGAGCCTCGCCGAAGGCGGCCACCTGACCCACGGCATGCCGCTGA
ACATGAGCGGCAAGTGGTTCAACATCGTGTCGTACGGCCTGAACGAGAAGGAAGAGATCGACTACGACGCGCTGGAAGCC
AAGGCCCGCGAGCACAAGCCCAAGCTGATCATCGCCGGTGCCTCCGCCTACAGCCTGCGCATCGATTTCGAGCGCTTCGC
GAAGATCGCCAAGGAAGTCGGCGCGATCTTCTGGGTGGACATCGCCCACTATGCCGGCCTGGTGGTCGCGGGTGAATATC
CCAACCCCGTGCCCTTCGCCGACGTGGTCACCTCCACGACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCATCATCCTC
ATGAAGGCCGAACACGAGAAGGCGATCAACTCCGCCATCTTCCCGGGCCTGCAGGGCGGCCCGCTGGAGCACGTCATCGC
CGCCAAGGCCGTGGCCTTCAAGGAAGCGCTGACGCCGGAATTCAAGGCCTACCAGCAGCAGGTCGCGAAGAACGCCAAGG
TGTTCGCCGAAACGCTGATCGAACGCGGCCTGCGCATCATCAGCGGCCGCACGGAGAGCCACGTCATGCTCGTGGACCTG
CGCGCCAAGGGCATCACCGGCAAGGCGGCCGAAGCGGCCCTGGGCCAGGCCCATATCACCATCAACAAGAACTCCATTCC
GAACGATCCGGAAAAGCCGATGGTGACCAGCGGCATCCGCGTGGGCACGCCCGCGATCACGACGCGGGGCTTCAAGGAAG
AAGAGACGCGCATCACCGCGAACCTGCTGGCCGACGTGCTGGAGAACCCGAACGACGAAGCCAACCTGGCCGCGGTGCGC
GAGAAGGTGCACGCGCTCACGAGCCGCTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
GGGAAGCGTGCCGCACGGGCTGCAAGGCCCGTTGTGTTCCGCCGTTCGCCTGGGCAGCCCTTGTTTTTCCAAGGGACACC
ATTCACAGGACTGCCACGCC

Downstream 100 bases:

>100_bases
CCGCGGCGCAGCCCCGAGCCCGCCGCCCCTGCAATGAAGTGCCCGTTCTGCAGCCACCCCGAGACGCAGGTCGTCGAAAC
GCGCGTGGCCGAGGATGGAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MYQRNILVEQADPEVWAAIQAENLRQEQHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RVKKLFGADAANVQPNSGSQANQAVLLAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNIVSYGLNEKEEIDYDALEA
KAREHKPKLIIAGASAYSLRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALTPEFKAYQQQVAKNAKVFAETLIERGLRIISGRTESHVMLVDL
RAKGITGKAAEAALGQAHITINKNSIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRITANLLADVLENPNDEANLAAVR
EKVHALTSRFPVYR

Sequences:

>Translated_414_residues
MYQRNILVEQADPEVWAAIQAENLRQEQHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RVKKLFGADAANVQPNSGSQANQAVLLAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNIVSYGLNEKEEIDYDALEA
KAREHKPKLIIAGASAYSLRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALTPEFKAYQQQVAKNAKVFAETLIERGLRIISGRTESHVMLVDL
RAKGITGKAAEAALGQAHITINKNSIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRITANLLADVLENPNDEANLAAVR
EKVHALTSRFPVYR
>Mature_414_residues
MYQRNILVEQADPEVWAAIQAENLRQEQHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RVKKLFGADAANVQPNSGSQANQAVLLAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNIVSYGLNEKEEIDYDALEA
KAREHKPKLIIAGASAYSLRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALTPEFKAYQQQVAKNAKVFAETLIERGLRIISGRTESHVMLVDL
RAKGITGKAAEAALGQAHITINKNSIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRITANLLADVLENPNDEANLAAVR
EKVHALTSRFPVYR

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=451, Percent_Identity=42.350332594235, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI261862352, Length=451, Percent_Identity=42.350332594235, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862350, Length=451, Percent_Identity=42.350332594235, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862348, Length=451, Percent_Identity=42.350332594235, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862346, Length=450, Percent_Identity=41.5555555555556, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547186, Length=453, Percent_Identity=41.9426048565121, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=39.9543378995434, Blast_Score=278, Evalue=7e-75,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=63.7019230769231, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25144732, Length=398, Percent_Identity=46.7336683417085, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI25144729, Length=398, Percent_Identity=46.7336683417085, Blast_Score=341, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6319739, Length=393, Percent_Identity=44.529262086514, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6323087, Length=390, Percent_Identity=45.1282051282051, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24640005, Length=390, Percent_Identity=46.9230769230769, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI221329721, Length=390, Percent_Identity=46.9230769230769, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_ACIAC (A1TRH1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971333.1
- ProteinModelPortal:   A1TRH1
- SMR:   A1TRH1
- STRING:   A1TRH1
- GeneID:   4668184
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2992
- NMPDR:   fig|397945.5.peg.2546
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   LNGNRMF
- PhylomeDB:   A1TRH1
- ProtClustDB:   PRK00011
- BioCyc:   AAVE397945:AAVE_2992-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45047; Mature: 45047

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQRNILVEQADPEVWAAIQAENLRQEQHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCHHEEEHHHHHCCHHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVVEQLAIDRVKKLFGADAANVQPNSGSQANQAVLLAFLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LAEGGHLTHGMPLNMSGKWFNIVSYGLNEKEEIDYDALEAKAREHKPKLIIAGASAYSLR
ECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHCCCCEEEEECCEEEEE
IDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHCCEEEEEHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALTPEFKAYQQQVAKNAKVFAETLI
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ERGLRIISGRTESHVMLVDLRAKGITGKAAEAALGQAHITINKNSIPNDPEKPMVTSGIR
HCCHHEECCCCCCEEEEEEEECCCCCCCHHHHHCCEEEEEEECCCCCCCCCCCCEECCEE
VGTPAITTRGFKEEETRITANLLADVLENPNDEANLAAVREKVHALTSRFPVYR
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYQRNILVEQADPEVWAAIQAENLRQEQHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCHHEEEHHHHHCCHHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVVEQLAIDRVKKLFGADAANVQPNSGSQANQAVLLAFLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LAEGGHLTHGMPLNMSGKWFNIVSYGLNEKEEIDYDALEAKAREHKPKLIIAGASAYSLR
ECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHCCCCEEEEECCEEEEE
IDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHCCEEEEEHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALTPEFKAYQQQVAKNAKVFAETLI
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ERGLRIISGRTESHVMLVDLRAKGITGKAAEAALGQAHITINKNSIPNDPEKPMVTSGIR
HCCHHEECCCCCCEEEEEEEECCCCCCCHHHHHCCEEEEEEECCCCCCCCCCCCEECCEE
VGTPAITTRGFKEEETRITANLLADVLENPNDEANLAAVREKVHALTSRFPVYR
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA