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The map label for this gene is lpxB [H]

Identifier: 120610516

GI number: 120610516

Start: 1990201

End: 1991352

Strand: Direct

Name: lpxB [H]

Synonym: Aave_1836

Alternate gene names: 120610516

Gene position: 1990201-1991352 (Clockwise)

Preceding gene: 120610515

Following gene: 120610517

Centisome position: 37.18

GC content: 71.53

Gene sequence:

>1152_bases
ATGCAAGACGCCCTTCGCATCGCGATGGTGGCCGGCGAGACGTCCGGCGACCTGCTCGCCGGCCTGCTCCTGGACGGCCT
GCACGCGCAGTGGCCGGCGGTGTCCGCGCAGGGCATCGGCGGGCCGCAGATGGAACGCCGGGGCTTCCATTCCCTGTGGC
CGAGCGAGCGCCTCGCGGTGCACGGCTACAGCGTCGAGCTGGTGCGCCGCCTCTGGGGCATCGTGCGCATCCGCCAGCAA
TTGCGCAGCCGCCTGCTCGCGGAGCGGCCCGGCCTCTTCATCGGCATCGATGCCCCGGATTTCAACCTGGGCCTGGAGGC
CGACCTGCGCGCCGCGGGCATCAGGACCGTGCATTTCGTCTGCCCGTCCATCTGGGCCTGGCGTGCGGAGCGGGTCCACA
AGATCCGGCGCAGCGCCGACCATGTGCTGTGCATCTTCCCCTTCGAGCCCGAACTGCTGGCGCGCCACGGCATCGACGCG
ACCTACGTGGGCCATCCGCTGGCCCAGGTCATTCCGATGGAGCCCGACCGCCTCGCGGCCCGCGCGCAGCTGGGGCTGGG
CGCGGACGACGAGGTGCTGGCCATCCTGCCCGGCAGCCGCTCCGCGGAAGTCGCCTACATCGCCCGGCCGTTCTTCCAGG
CGGCGGCGCTGCTGCGCCAAGCGCGGCCCGGGCTGAAGATGGTGGTGCCGGCGGTACCGGCGCTGCGCGCGCGCATCGAG
CAGATCGCCGCCGAGTGCGGAGTGCGCGATGCGTTGCTGATAACGCCCGGGCAATCCCACACGGTGCTGGCCGCCTGCGA
CTGCACGCTCATCGCCAGCGGGACCGCGACGCTGGAGGCCGCGCTGTTCAAGCGGCCCATGGTCATCGCCTACCACATGC
ACCCCATCAGCTGGCGCCTGATGTGCCGCAAGCAGCTGCAGCCCTGGGTGGGGCTGCCCAACATCCTGTGCGGCGATTTC
GTGGTGCCCGAACTGCTGCAGGACGCGGCCACGCCGCAGGCCCTGGCCACGGCCGTGATGCAGTGGCTGGACGCACCAGC
CGGCCAGCGCGACGCGCTGGCGCGGCGCTTCACCGCGCTGCACGAGGAACTGCGCCGCGATACCCCGAGATTGGCCGCCG
ATGCGATCCAGAAAATCCTTGCCGCGCGTTGA

Upstream 100 bases:

>100_bases
GCGGCCGAGCACCCCGAGGCCGCGGGCGACATCACCCTGCTGCGCGATTTCATCGTCTCCTCGACGCGCGGCATCGCGCG
CTGAAGGGAAGCGCGCAGCC

Downstream 100 bases:

>100_bases
GCAGGCCCATCTGCCATGGCATCCGCCGGGACTCGTCGCGGGCGTGGACGAGGCGGGCCGCGGGCCGCTGGCCGGGCCCG
TGGTGGCCGCGGCCGTCATC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQDALRIAMVAGETSGDLLAGLLLDGLHAQWPAVSAQGIGGPQMERRGFHSLWPSERLAVHGYSVELVRRLWGIVRIRQQ
LRSRLLAERPGLFIGIDAPDFNLGLEADLRAAGIRTVHFVCPSIWAWRAERVHKIRRSADHVLCIFPFEPELLARHGIDA
TYVGHPLAQVIPMEPDRLAARAQLGLGADDEVLAILPGSRSAEVAYIARPFFQAAALLRQARPGLKMVVPAVPALRARIE
QIAAECGVRDALLITPGQSHTVLAACDCTLIASGTATLEAALFKRPMVIAYHMHPISWRLMCRKQLQPWVGLPNILCGDF
VVPELLQDAATPQALATAVMQWLDAPAGQRDALARRFTALHEELRRDTPRLAADAIQKILAAR

Sequences:

>Translated_383_residues
MQDALRIAMVAGETSGDLLAGLLLDGLHAQWPAVSAQGIGGPQMERRGFHSLWPSERLAVHGYSVELVRRLWGIVRIRQQ
LRSRLLAERPGLFIGIDAPDFNLGLEADLRAAGIRTVHFVCPSIWAWRAERVHKIRRSADHVLCIFPFEPELLARHGIDA
TYVGHPLAQVIPMEPDRLAARAQLGLGADDEVLAILPGSRSAEVAYIARPFFQAAALLRQARPGLKMVVPAVPALRARIE
QIAAECGVRDALLITPGQSHTVLAACDCTLIASGTATLEAALFKRPMVIAYHMHPISWRLMCRKQLQPWVGLPNILCGDF
VVPELLQDAATPQALATAVMQWLDAPAGQRDALARRFTALHEELRRDTPRLAADAIQKILAAR
>Mature_383_residues
MQDALRIAMVAGETSGDLLAGLLLDGLHAQWPAVSAQGIGGPQMERRGFHSLWPSERLAVHGYSVELVRRLWGIVRIRQQ
LRSRLLAERPGLFIGIDAPDFNLGLEADLRAAGIRTVHFVCPSIWAWRAERVHKIRRSADHVLCIFPFEPELLARHGIDA
TYVGHPLAQVIPMEPDRLAARAQLGLGADDEVLAILPGSRSAEVAYIARPFFQAAALLRQARPGLKMVVPAVPALRARIE
QIAAECGVRDALLITPGQSHTVLAACDCTLIASGTATLEAALFKRPMVIAYHMHPISWRLMCRKQLQPWVGLPNILCGDF
VVPELLQDAATPQALATAVMQWLDAPAGQRDALARRFTALHEELRRDTPRLAADAIQKILAAR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=376, Percent_Identity=41.4893617021277, Blast_Score=265, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42012; Mature: 42012

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDALRIAMVAGETSGDLLAGLLLDGLHAQWPAVSAQGIGGPQMERRGFHSLWPSERLAV
CCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHCCCCCCEEE
HGYSVELVRRLWGIVRIRQQLRSRLLAERPGLFIGIDAPDFNLGLEADLRAAGIRTVHFV
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHCCCHHHHHH
CPSIWAWRAERVHKIRRSADHVLCIFPFEPELLARHGIDATYVGHPLAQVIPMEPDRLAA
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHH
RAQLGLGADDEVLAILPGSRSAEVAYIARPFFQAAALLRQARPGLKMVVPAVPALRARIE
HHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
QIAAECGVRDALLITPGQSHTVLAACDCTLIASGTATLEAALFKRPMVIAYHMHPISWRL
HHHHHCCCCCEEEECCCCCCEEEEEECEEEEECCCHHHHHHHHCCCEEEEEECCCHHHHH
MCRKQLQPWVGLPNILCGDFVVPELLQDAATPQALATAVMQWLDAPAGQRDALARRFTAL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
HEELRRDTPRLAADAIQKILAAR
HHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDALRIAMVAGETSGDLLAGLLLDGLHAQWPAVSAQGIGGPQMERRGFHSLWPSERLAV
CCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHCCCCCCEEE
HGYSVELVRRLWGIVRIRQQLRSRLLAERPGLFIGIDAPDFNLGLEADLRAAGIRTVHFV
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHCCCHHHHHH
CPSIWAWRAERVHKIRRSADHVLCIFPFEPELLARHGIDATYVGHPLAQVIPMEPDRLAA
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHH
RAQLGLGADDEVLAILPGSRSAEVAYIARPFFQAAALLRQARPGLKMVVPAVPALRARIE
HHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
QIAAECGVRDALLITPGQSHTVLAACDCTLIASGTATLEAALFKRPMVIAYHMHPISWRL
HHHHHCCCCCEEEECCCCCCEEEEEECEEEEECCCHHHHHHHHCCCEEEEEECCCHHHHH
MCRKQLQPWVGLPNILCGDFVVPELLQDAATPQALATAVMQWLDAPAGQRDALARRFTAL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
HEELRRDTPRLAADAIQKILAAR
HHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA