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The map label for this gene is lpxA

Identifier: 120610515

GI number: 120610515

Start: 1989396

End: 1990184

Strand: Direct

Name: lpxA

Synonym: Aave_1835

Alternate gene names: 120610515

Gene position: 1989396-1990184 (Clockwise)

Preceding gene: 120610514

Following gene: 120610516

Centisome position: 37.17

GC content: 68.69

Gene sequence:

>789_bases
ATGAGCAGCATCCATTCCACGGCCATCGTCGATCCGGGCGCCGAGCTGGACAGCTCGGTCACCGTCGGCCCCTATGCGGT
CATCGGCCCCAAGGTGCGCATCGGGGCCGGGACGAGCGTCGGGCCGCACTGCGTCATCGAGGGCCGCACGACGATCGGGC
GCGACAACCGGATCTTCCAGTTCGCCTCGCTCGGCGCGATTCCGCAGGACAAGAAATACGCCGGGGAAGACACCTGCCTG
GAGATCGGCGACCGCAACACGATCCGCGAGTTCTGCACCTTCAACCTCGGCGTGCCGGGCGCGGGGGGCGTCACGCGCGT
GGGCGACGACAACTGGATCATGGCCTACTGCCACATCGCGCACGACTGCCTGGTGGGCAACCACACCACGCTCTCGAACA
ACACCACGCTGGCCGGGCACGTCGAGCTGGGCGACTGGGTGACCGTCGGCGGGCTGGTGGGCATCCACCAGTTCGTGAAG
ATCGGCGCGCACGCGATGGTGGGGTTCGCTTCGGCGGTATCGCAGGACGTGCCCCCCTTCATGCTGGTCGATGGCAATCC
GATGGGCGTGCGCGGCTTCAACATCGTGGGCCTGAAGCGCCGCGGCTTCTCCGCGGACCGCCTCGCCGCGGTCAAGCAGA
TGCATCGCCTGCTGTACCGCCAGGGGCTGACGCTGGAGGCGGCCGCCAAGGCGATCGAGGAGCTTGCGGCCGAGCACCCC
GAGGCCGCGGGCGACATCACCCTGCTGCGCGATTTCATCGTCTCCTCGACGCGCGGCATCGCGCGCTGA

Upstream 100 bases:

>100_bases
AGTTCGGCGGCGTGGCGCGCGTGGGCGACAGCGTGGCCTGCGAAGCCGAGATCATGTGCACCATGCGGACCGTCGCCTGA
AGGGCTGAGGGCGCGGGACC

Downstream 100 bases:

>100_bases
AGGGAAGCGCGCAGCCATGCAAGACGCCCTTCGCATCGCGATGGTGGCCGGCGAGACGTCCGGCGACCTGCTCGCCGGCC
TGCTCCTGGACGGCCTGCAC

Product: acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSSIHSTAIVDPGAELDSSVTVGPYAVIGPKVRIGAGTSVGPHCVIEGRTTIGRDNRIFQFASLGAIPQDKKYAGEDTCL
EIGDRNTIREFCTFNLGVPGAGGVTRVGDDNWIMAYCHIAHDCLVGNHTTLSNNTTLAGHVELGDWVTVGGLVGIHQFVK
IGAHAMVGFASAVSQDVPPFMLVDGNPMGVRGFNIVGLKRRGFSADRLAAVKQMHRLLYRQGLTLEAAAKAIEELAAEHP
EAAGDITLLRDFIVSSTRGIAR

Sequences:

>Translated_262_residues
MSSIHSTAIVDPGAELDSSVTVGPYAVIGPKVRIGAGTSVGPHCVIEGRTTIGRDNRIFQFASLGAIPQDKKYAGEDTCL
EIGDRNTIREFCTFNLGVPGAGGVTRVGDDNWIMAYCHIAHDCLVGNHTTLSNNTTLAGHVELGDWVTVGGLVGIHQFVK
IGAHAMVGFASAVSQDVPPFMLVDGNPMGVRGFNIVGLKRRGFSADRLAAVKQMHRLLYRQGLTLEAAAKAIEELAAEHP
EAAGDITLLRDFIVSSTRGIAR
>Mature_261_residues
SSIHSTAIVDPGAELDSSVTVGPYAVIGPKVRIGAGTSVGPHCVIEGRTTIGRDNRIFQFASLGAIPQDKKYAGEDTCLE
IGDRNTIREFCTFNLGVPGAGGVTRVGDDNWIMAYCHIAHDCLVGNHTTLSNNTTLAGHVELGDWVTVGGLVGIHQFVKI
GAHAMVGFASAVSQDVPPFMLVDGNPMGVRGFNIVGLKRRGFSADRLAAVKQMHRLLYRQGLTLEAAAKAIEELAAEHPE
AAGDITLLRDFIVSSTRGIAR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=49.8069498069498, Blast_Score=263, Evalue=7e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_ACIAC (A1TN81)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970193.1
- ProteinModelPortal:   A1TN81
- STRING:   A1TN81
- GeneID:   4665655
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1835
- NMPDR:   fig|397945.5.peg.1588
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   A1TN81
- BioCyc:   AAVE397945:AAVE_1835-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27774; Mature: 27643

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIHSTAIVDPGAELDSSVTVGPYAVIGPKVRIGAGTSVGPHCVIEGRTTIGRDNRIFQ
CCCCCCCEEECCCCCCCCCEEECCEEEECCEEEECCCCCCCCEEEEECCCEECCCCCEEE
FASLGAIPQDKKYAGEDTCLEIGDRNTIREFCTFNLGVPGAGGVTRVGDDNWIMAYCHIA
EECCCCCCCCCCCCCCCCEEEECCCHHHHHHHEECCCCCCCCCCEEECCCCEEEEEEEHH
HDCLVGNHTTLSNNTTLAGHVELGDWVTVGGLVGIHQFVKIGAHAMVGFASAVSQDVPPF
HHHCCCCCEEECCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
MLVDGNPMGVRGFNIVGLKRRGFSADRLAAVKQMHRLLYRQGLTLEAAAKAIEELAAEHP
EEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
EAAGDITLLRDFIVSSTRGIAR
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSIHSTAIVDPGAELDSSVTVGPYAVIGPKVRIGAGTSVGPHCVIEGRTTIGRDNRIFQ
CCCCCCEEECCCCCCCCCEEECCEEEECCEEEECCCCCCCCEEEEECCCEECCCCCEEE
FASLGAIPQDKKYAGEDTCLEIGDRNTIREFCTFNLGVPGAGGVTRVGDDNWIMAYCHIA
EECCCCCCCCCCCCCCCCEEEECCCHHHHHHHEECCCCCCCCCCEEECCCCEEEEEEEHH
HDCLVGNHTTLSNNTTLAGHVELGDWVTVGGLVGIHQFVKIGAHAMVGFASAVSQDVPPF
HHHCCCCCEEECCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
MLVDGNPMGVRGFNIVGLKRRGFSADRLAAVKQMHRLLYRQGLTLEAAAKAIEELAAEHP
EEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
EAAGDITLLRDFIVSSTRGIAR
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA