Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 120610507

GI number: 120610507

Start: 1980844

End: 1981587

Strand: Direct

Name: uppS [H]

Synonym: Aave_1827

Alternate gene names: 120610507

Gene position: 1980844-1981587 (Clockwise)

Preceding gene: 120610506

Following gene: 120610508

Centisome position: 37.01

GC content: 70.7

Gene sequence:

>744_bases
ATGCCTTCCATGTCCGCCGCCTCGCCAGCCGTCCCCCACCACGTCGCCATCGTCATGGATGGCAATGGCCGGTGGGCCAC
GCGCCGCTTCCTGCCGCGGCTGGCCGGCCACAAGCAGGGGGTGGAGGCGCTCAAGCGCTGCGCCCGCGACTGCGTGGAGC
GCGGCGTGGCCGTGCTGACCGTCTTCGCCTTCTCCTCCGAGAACTGGAACCGCCCCGCCGACGAGGTGTCCGGCCTCATG
GACCTGCTGGCCAAGGCGCTCGCGCGCGAGGTGCCGCAACTGCAGAAGGACGGTGTGCGCCTGCACTTCGTGGGCGAGAG
GTCCACGCTGTCCGAGAAGGTCCGCGCCGGCCTGGCGCAGGCTGAAGCCGTCACCGCGCACAACACCCGGCTGGTGCTCA
ACGTCTGCTTCAACTACGGAGGCCGCTGGGACATCGCCCAGGCGGCCTCCGCGCTCGCCGCGCGTGGCGAGCCCATCACC
GAAGCCAGCCTCCACACCGCCATGGGCCTGGCCCACGTGCCGGATCCCGACCTGGTGATCCGCACGGGCGGCGAGATGCG
CATCAGCAATTTCCTGCTGTGGCAGTGCGCGTATTCCGAGCTGTACTTCAGCGACCGCCTCTGGCCCGATTTCGACGGCG
CCGCCCTGGACCAGGCCATCGCCGCCTACGGGGCACGCGAGCGCCGGTTCGGCAAGACATCCGAGCAACTGCTGGCCTCC
CCGACCTCGTCGGCGTGCGCCTGA

Upstream 100 bases:

>100_bases
AAGGTGACCGACAAGCACATCGCCGAAGTCGATGCGCTCGTGGCCGCCAAGGAACAGGAAATCATGGCGGTCTGATCGGC
CCGTTGCACGGGTTCGATCG

Downstream 100 bases:

>100_bases
AGGGGTTTCCCATGCTGGTCACGCGCATCCTCACGGCCATCGTCCTGCTGGCCATCCTGTTGCCGGCGCTCTTCGCCGGC
TCGGTCGTGCCTTTCGCGGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MPSMSAASPAVPHHVAIVMDGNGRWATRRFLPRLAGHKQGVEALKRCARDCVERGVAVLTVFAFSSENWNRPADEVSGLM
DLLAKALAREVPQLQKDGVRLHFVGERSTLSEKVRAGLAQAEAVTAHNTRLVLNVCFNYGGRWDIAQAASALAARGEPIT
EASLHTAMGLAHVPDPDLVIRTGGEMRISNFLLWQCAYSELYFSDRLWPDFDGAALDQAIAAYGARERRFGKTSEQLLAS
PTSSACA

Sequences:

>Translated_247_residues
MPSMSAASPAVPHHVAIVMDGNGRWATRRFLPRLAGHKQGVEALKRCARDCVERGVAVLTVFAFSSENWNRPADEVSGLM
DLLAKALAREVPQLQKDGVRLHFVGERSTLSEKVRAGLAQAEAVTAHNTRLVLNVCFNYGGRWDIAQAASALAARGEPIT
EASLHTAMGLAHVPDPDLVIRTGGEMRISNFLLWQCAYSELYFSDRLWPDFDGAALDQAIAAYGARERRFGKTSEQLLAS
PTSSACA
>Mature_246_residues
PSMSAASPAVPHHVAIVMDGNGRWATRRFLPRLAGHKQGVEALKRCARDCVERGVAVLTVFAFSSENWNRPADEVSGLMD
LLAKALAREVPQLQKDGVRLHFVGERSTLSEKVRAGLAQAEAVTAHNTRLVLNVCFNYGGRWDIAQAASALAARGEPITE
ASLHTAMGLAHVPDPDLVIRTGGEMRISNFLLWQCAYSELYFSDRLWPDFDGAALDQAIAAYGARERRFGKTSEQLLASP
TSSACA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=37.6681614349776, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=37.6681614349776, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=48.8986784140969, Blast_Score=222, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=35.3448275862069, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=37.3831775700935, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=33.0396475770925, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18857969, Length=222, Percent_Identity=39.6396396396396, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26831; Mature: 26700

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSMSAASPAVPHHVAIVMDGNGRWATRRFLPRLAGHKQGVEALKRCARDCVERGVAVLT
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHEEE
VFAFSSENWNRPADEVSGLMDLLAKALAREVPQLQKDGVRLHFVGERSTLSEKVRAGLAQ
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHH
AEAVTAHNTRLVLNVCFNYGGRWDIAQAASALAARGEPITEASLHTAMGLAHVPDPDLVI
HHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEE
RTGGEMRISNFLLWQCAYSELYFSDRLWPDFDGAALDQAIAAYGARERRFGKTSEQLLAS
ECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCHHHHHCC
PTSSACA
CCCCCCC
>Mature Secondary Structure 
PSMSAASPAVPHHVAIVMDGNGRWATRRFLPRLAGHKQGVEALKRCARDCVERGVAVLT
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHEEE
VFAFSSENWNRPADEVSGLMDLLAKALAREVPQLQKDGVRLHFVGERSTLSEKVRAGLAQ
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHH
AEAVTAHNTRLVLNVCFNYGGRWDIAQAASALAARGEPITEASLHTAMGLAHVPDPDLVI
HHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEE
RTGGEMRISNFLLWQCAYSELYFSDRLWPDFDGAALDQAIAAYGARERRFGKTSEQLLAS
ECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCHHHHHCC
PTSSACA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA