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The map label for this gene is pyrH

Identifier: 120610505

GI number: 120610505

Start: 1979465

End: 1980187

Strand: Direct

Name: pyrH

Synonym: Aave_1825

Alternate gene names: 120610505

Gene position: 1979465-1980187 (Clockwise)

Preceding gene: 120610504

Following gene: 120610506

Centisome position: 36.98

GC content: 66.53

Gene sequence:

>723_bases
ATGTCCGTCGCCGCTCCAGCCCACAAGCGCATTCTGCTCAAGTTGTCTGGAGAGGCTCTCATGGGTGACGACGCCTTCGG
CATCAACCGCGCCACCATCGTCCGGATGGTCGAGGAGATCGCCGAAGTCACGCGCATGGGCGTGCAGGTCGCGGTGGTGA
TCGGGGGAGGGAACATCTTCCGCGGCGTCGCGGGAGGCTCCGTCGGCATGGACCGCGCCACCGCCGACTACATGGGCATG
CTGGCCACGGTCATGAATGCCCTCGCGCTCGCCGATGCCATGGACAAGCAGGGCCTCATCGCCCGCGTGATGTCGGCCAT
CGGCATCGAGCAGGTGGTGGAGCCGTACGTGCGGCCCAAGGCGCTGCAGTACCTGGAAGAGGGCAAGGTCGTGGTGTTCG
CCGCGGGCACCGGCAATCCCTTCTTCACGACGGACACCGCCGCCGCGCTGCGCGGCGCCGAGATCGGCGCCGAAGTGGTG
CTCAAGGCGACCAAGGTGGACGGCGTGTACACCGCCGATCCCAAGAAGGATCCGACGGCGACGCGCTATACCAAGCTCAC
CTTCGACGAGGCCATGTCGCGCAACCTCGGCATCCTCGATGCCACGGCGTTCGCGCTCTGCCGCGACCAGAAGCTGCCCA
TCCGGGTCTTCTCGATCGTGAAGCACGGCGCGCTCAAGCGCGTGGTGATGGGCGAGGACGAAGGAACGCTGGTGTACGCT
TGA

Upstream 100 bases:

>100_bases
TCGCGGCGGAAGTGGCCGCGCAGGTGGCCGCCGCCAAGGCCGCTGCCTGATCCCTGGTCCCGTACAGTTCCCCGATTCCA
CCACCCGAAGAGAAACGCCC

Downstream 100 bases:

>100_bases
CGCCCGACTGCACCGTGCCCGCGGCGGCTTGGCGCCGACCCGGGCGACGGATGCGCGCACAGGAGAACACATGACGATTG
CCGACATCAAGAAAAACACC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSVAAPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRMGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGM
LATVMNALALADAMDKQGLIARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVV
LKATKVDGVYTADPKKDPTATRYTKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA

Sequences:

>Translated_240_residues
MSVAAPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRMGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGM
LATVMNALALADAMDKQGLIARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVV
LKATKVDGVYTADPKKDPTATRYTKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
>Mature_239_residues
SVAAPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRMGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGML
ATVMNALALADAMDKQGLIARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVL
KATKVDGVYTADPKKDPTATRYTKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=58.2978723404255, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ACIAC (A1TN71)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970183.1
- ProteinModelPortal:   A1TN71
- SMR:   A1TN71
- STRING:   A1TN71
- GeneID:   4666330
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1825
- NMPDR:   fig|397945.5.peg.1579
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A1TN71
- ProtClustDB:   PRK00358
- BioCyc:   AAVE397945:AAVE_1825-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25455; Mature: 25324

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: BINDING 56-56 BINDING 57-57 BINDING 61-61 BINDING 76-76 BINDING 164-164 BINDING 170-170 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAAPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRMGVQVAVVIGGGNIF
CCCCCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
RGVAGGSVGMDRATADYMGMLATVMNALALADAMDKQGLIARVMSAIGIEQVVEPYVRPK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCHH
ALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVLKATKVDGVYTADPKKDPTA
HHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHHCCHHHEEEEEECCCEEECCCCCCCCC
TRYTKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
CCEEEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEC
>Mature Secondary Structure 
SVAAPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRMGVQVAVVIGGGNIF
CCCCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
RGVAGGSVGMDRATADYMGMLATVMNALALADAMDKQGLIARVMSAIGIEQVVEPYVRPK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCHH
ALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVLKATKVDGVYTADPKKDPTA
HHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHHCCHHHEEEEEECCCEEECCCCCCCCC
TRYTKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
CCEEEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA