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The map label for this gene is yfmF [H]

Identifier: 120610227

GI number: 120610227

Start: 1708499

End: 1709299

Strand: Direct

Name: yfmF [H]

Synonym: Aave_1542

Alternate gene names: 120610227

Gene position: 1708499-1709299 (Clockwise)

Preceding gene: 120610226

Following gene: 120610228

Centisome position: 31.92

GC content: 76.9

Gene sequence:

>801_bases
ATGGACCGCACCATCGCCCTGCAGGCGTCCGGCCTCTGCGCATCGTTCGGCGGCACGCCCGTGCTGCGCGACGTGGACCT
GCGCATTCCCGCCGGCTGCTGGACCAGCGTGGTCGGCCCGAACGGCGCCGGCAAATCGACCCTGCTCAAGGCCCTGGCGG
GCCTGCTGCCGGGCGGCGCCGTGCGCGGGCATATCGATTTGATGGGCCGTCCGCTGCCGCGCTGGGGCGCGCGGGAGCGC
GCGCGCCAGCTCGCGTGGCTGGGGCAGGGCGAGGCCGGCTCCGACGGCCTGCCTGCCTACGACATCGCCATGCTGGGCCG
CCTGCCGCACCAGCCCTGGCTCGCGCCGCCCAGCCCGGCGGACCATGCGGCCGTGCGCGCTGCGCTGGAGGCCACGCAGG
CCTGGGCGCGGCGCCACCGCCCGCTCGCCGAACTCTCCGGCGGCGAGCGCCAGCGCGTGCTGCTGGCCCGTGCGCTGGCC
GTGCAGGCCCCGGTGCTGCTCATGGACGAGCCGCTCGCCCACCTCGACCCGCCCCACCAGGCCGACTGGCTGCAGACCGT
GCGCGGCCTGGCGCGGCAGGGCTGCGCGGTGGTGAGCGTGCTGCACGAGGTGTCGTTCGCGCTGCAGGCCGATGCGCTGG
TCGTCCTGGCCGAAGGCCGGGTGCTCCACCATGGGCCGGGCGATGATCCCGCCACCCATGCGGCGCTGGAGGCCGTGTTC
GGCCACCGCATCCGCGTGCGCGAGGTGGACGGCCTGCGCGTGGCGGTACCGTGCGTCGGTCCCGCCGCGCCCGGCGGCTG
A

Upstream 100 bases:

>100_bases
CAGGAACTGCCCGTGGGCGTGCTCACGGCGGCCCTGGGCGGCAGCTACCTGCTGTGGCTCATGCACCGGCGCGCCCGGCT
GGGCCGCGGAGGCTGAACGC

Downstream 100 bases:

>100_bases
TGCCAGCGTGCCGGACCGGATCTTTTTCTTCTCCCATTCATCTTTGTTTCGCATGCAGATCGAATCTCCCCCCACCGAGC
GCCGCTCGGAGAAGCCGGAC

Product: ABC transporter-like protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric-citrate import ATP-binding protein [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MDRTIALQASGLCASFGGTPVLRDVDLRIPAGCWTSVVGPNGAGKSTLLKALAGLLPGGAVRGHIDLMGRPLPRWGARER
ARQLAWLGQGEAGSDGLPAYDIAMLGRLPHQPWLAPPSPADHAAVRAALEATQAWARRHRPLAELSGGERQRVLLARALA
VQAPVLLMDEPLAHLDPPHQADWLQTVRGLARQGCAVVSVLHEVSFALQADALVVLAEGRVLHHGPGDDPATHAALEAVF
GHRIRVREVDGLRVAVPCVGPAAPGG

Sequences:

>Translated_266_residues
MDRTIALQASGLCASFGGTPVLRDVDLRIPAGCWTSVVGPNGAGKSTLLKALAGLLPGGAVRGHIDLMGRPLPRWGARER
ARQLAWLGQGEAGSDGLPAYDIAMLGRLPHQPWLAPPSPADHAAVRAALEATQAWARRHRPLAELSGGERQRVLLARALA
VQAPVLLMDEPLAHLDPPHQADWLQTVRGLARQGCAVVSVLHEVSFALQADALVVLAEGRVLHHGPGDDPATHAALEAVF
GHRIRVREVDGLRVAVPCVGPAAPGG
>Mature_266_residues
MDRTIALQASGLCASFGGTPVLRDVDLRIPAGCWTSVVGPNGAGKSTLLKALAGLLPGGAVRGHIDLMGRPLPRWGARER
ARQLAWLGQGEAGSDGLPAYDIAMLGRLPHQPWLAPPSPADHAAVRAALEATQAWARRHRPLAELSGGERQRVLLARALA
VQAPVLLMDEPLAHLDPPHQADWLQTVRGLARQGCAVVSVLHEVSFALQADALVVLAEGRVLHHGPGDDPATHAALEAVF
GHRIRVREVDGLRVAVPCVGPAAPGG

Specific function: Part of the ABC transporter complex YfmCDEF involved in citrate-dependent Fe(3+) import. Responsible for energy coupling to the transport system (Probable) [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI190343023, Length=233, Percent_Identity=30.9012875536481, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI42741659, Length=245, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI215820660, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI20143975, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790739, Length=241, Percent_Identity=37.7593360995851, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786803, Length=270, Percent_Identity=32.2222222222222, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786345, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788761, Length=241, Percent_Identity=34.4398340248963, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790544, Length=236, Percent_Identity=33.8983050847458, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787029, Length=220, Percent_Identity=32.2727272727273, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788225, Length=248, Percent_Identity=30.6451612903226, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081709, Length=236, Percent_Identity=27.9661016949153, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786563, Length=230, Percent_Identity=33.4782608695652, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788002, Length=245, Percent_Identity=30.6122448979592, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787089, Length=245, Percent_Identity=31.0204081632653, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789593, Length=221, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081834, Length=230, Percent_Identity=31.7391304347826, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787370, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789672, Length=227, Percent_Identity=29.0748898678414, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI48994943, Length=241, Percent_Identity=29.045643153527, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788472, Length=216, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788450, Length=224, Percent_Identity=31.25, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1786872, Length=226, Percent_Identity=30.5309734513274, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48995001, Length=219, Percent_Identity=32.4200913242009, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790534, Length=197, Percent_Identity=32.48730964467, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788506, Length=214, Percent_Identity=29.9065420560748, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786703, Length=209, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI48994883, Length=226, Percent_Identity=27.8761061946903, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789032, Length=251, Percent_Identity=27.0916334661355, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789890, Length=231, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787759, Length=232, Percent_Identity=29.7413793103448, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789891, Length=190, Percent_Identity=30.5263157894737, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787792, Length=248, Percent_Identity=27.4193548387097, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=222, Percent_Identity=29.2792792792793, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994997, Length=231, Percent_Identity=30.3030303030303, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788644, Length=98, Percent_Identity=39.7959183673469, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992285, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363262, Length=236, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24581387, Length=225, Percent_Identity=31.1111111111111, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920532, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24580930, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581383, Length=225, Percent_Identity=31.1111111111111, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581385, Length=225, Percent_Identity=31.1111111111111, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24653245, Length=238, Percent_Identity=27.3109243697479, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI85724864, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24580555, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85816269, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24580553, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136662, Length=247, Percent_Identity=28.7449392712551, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 27933; Mature: 27933

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRTIALQASGLCASFGGTPVLRDVDLRIPAGCWTSVVGPNGAGKSTLLKALAGLLPGGA
CCCEEEEEECCCEECCCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCC
VRGHIDLMGRPLPRWGARERARQLAWLGQGEAGSDGLPAYDIAMLGRLPHQPWLAPPSPA
EEEEHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
DHAAVRAALEATQAWARRHRPLAELSGGERQRVLLARALAVQAPVLLMDEPLAHLDPPHQ
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCEECCCHHHCCCCCH
ADWLQTVRGLARQGCAVVSVLHEVSFALQADALVVLAEGRVLHHGPGDDPATHAALEAVF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHH
GHRIRVREVDGLRVAVPCVGPAAPGG
CCCEEEEECCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDRTIALQASGLCASFGGTPVLRDVDLRIPAGCWTSVVGPNGAGKSTLLKALAGLLPGGA
CCCEEEEEECCCEECCCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCC
VRGHIDLMGRPLPRWGARERARQLAWLGQGEAGSDGLPAYDIAMLGRLPHQPWLAPPSPA
EEEEHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
DHAAVRAALEATQAWARRHRPLAELSGGERQRVLLARALAVQAPVLLMDEPLAHLDPPHQ
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCEECCCHHHCCCCCH
ADWLQTVRGLARQGCAVVSVLHEVSFALQADALVVLAEGRVLHHGPGDDPATHAALEAVF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHH
GHRIRVREVDGLRVAVPCVGPAAPGG
CCCEEEEECCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9272861; 9384377 [H]