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The map label for this gene is hmuU [H]

Identifier: 120610226

GI number: 120610226

Start: 1707460

End: 1708494

Strand: Direct

Name: hmuU [H]

Synonym: Aave_1541

Alternate gene names: 120610226

Gene position: 1707460-1708494 (Clockwise)

Preceding gene: 120610225

Following gene: 120610227

Centisome position: 31.9

GC content: 77.58

Gene sequence:

>1035_bases
ATGAGGCCGGCGGGCGACGGGGCCGGGCATGCCGGCGGTGCCCGCCGGGCGGCGTGGCTGGCCGCGGGGCTGCTGCTGGC
CGGCACGGCCCTGGTGATGCTGGGCGCGAGCGTGGGCAGCACCGGCATCGGGCTGGCCTGGGGCCCCGATGCGGATCCCG
TGGCGCGGCAGATCCTCCGGGACATCCGCCTGCCGCGCACGCTGGGCGCCTGGCTCGCCGGGGCGCTGCTCGGCCTGTCC
GGCGCGGTGGCGCAGGGGCTGTTCCGCAATCCGCTGGCGGACCCGTACCTGCTGGGCAGCGCCTCGGGCGCGGCGCTCGG
GGGCGCGCTGGCCATGGCGCTGTTCGGCCTGTCGCCCGGCGCATCGCAGTGGCTCGCGCGGCTGGGCGTGACGGGCATGG
CCTTCCTCGGCGCCGTGGCGGCCGTGCTGCTCACGCTGGTGCTGGCGCGCGGCGTGCAGCACACGCTGCGGCTGCTGCTG
GCGGGCGTGATCGTGGGCGTGGTGCTCGGCGCCGCGCGCGACCTGGTGGAACTGGCCTCGCCCGAGATCCTGCAGGCCAT
GCAGGCCTTCACCCTGGGCAGCACCAGCTTCGTGGGCTGGATCGCCTGCGGGCTGATGGCCGGGGCCTGGGCACTGAGCG
CCGGCACCGCCTGGGTGCTGGCGCGCGCGCTGGACGGGCTGGTGCTGGGCGAGGCCACGGCGGCCAGCCTGGGCCTGCCG
CTCGCGCCCATGCGCGCGGGGCTGGTGGCGGCCATGGCGCTGGCCACCGGCACCGCGGTGGCGCAGACGGGCCTGATCGC
CTTCGTGGGCCTGGCCGCCCCGCACCTGGTGCGCTCCATCGCGCCGTCCACCCACCAGCGCCACGTGGTGCTCTCCAGCC
TCATGGGCGCGGTGCTGCTGCTGGCCGCGGACATCCTCGCGCGCTGGATCGTCGCGCCGCAGGAACTGCCCGTGGGCGTG
CTCACGGCGGCCCTGGGCGGCAGCTACCTGCTGTGGCTCATGCACCGGCGCGCCCGGCTGGGCCGCGGAGGCTGA

Upstream 100 bases:

>100_bases
GCGTGTTCTCCCCGCGCGAGGCCGACGTGGCGGTGCGCCCCGGCCCGCGCATGGCGGATGCCGCGCGCATCATGGCGCGC
TGCCTCGCGGACAAGGCGCC

Downstream 100 bases:

>100_bases
ACGCATGGACCGCACCATCGCCCTGCAGGCGTCCGGCCTCTGCGCATCGTTCGGCGGCACGCCCGTGCTGCGCGACGTGG
ACCTGCGCATTCCCGCCGGC

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRPAGDGAGHAGGARRAAWLAAGLLLAGTALVMLGASVGSTGIGLAWGPDADPVARQILRDIRLPRTLGAWLAGALLGLS
GAVAQGLFRNPLADPYLLGSASGAALGGALAMALFGLSPGASQWLARLGVTGMAFLGAVAAVLLTLVLARGVQHTLRLLL
AGVIVGVVLGAARDLVELASPEILQAMQAFTLGSTSFVGWIACGLMAGAWALSAGTAWVLARALDGLVLGEATAASLGLP
LAPMRAGLVAAMALATGTAVAQTGLIAFVGLAAPHLVRSIAPSTHQRHVVLSSLMGAVLLLAADILARWIVAPQELPVGV
LTAALGGSYLLWLMHRRARLGRGG

Sequences:

>Translated_344_residues
MRPAGDGAGHAGGARRAAWLAAGLLLAGTALVMLGASVGSTGIGLAWGPDADPVARQILRDIRLPRTLGAWLAGALLGLS
GAVAQGLFRNPLADPYLLGSASGAALGGALAMALFGLSPGASQWLARLGVTGMAFLGAVAAVLLTLVLARGVQHTLRLLL
AGVIVGVVLGAARDLVELASPEILQAMQAFTLGSTSFVGWIACGLMAGAWALSAGTAWVLARALDGLVLGEATAASLGLP
LAPMRAGLVAAMALATGTAVAQTGLIAFVGLAAPHLVRSIAPSTHQRHVVLSSLMGAVLLLAADILARWIVAPQELPVGV
LTAALGGSYLLWLMHRRARLGRGG
>Mature_344_residues
MRPAGDGAGHAGGARRAAWLAAGLLLAGTALVMLGASVGSTGIGLAWGPDADPVARQILRDIRLPRTLGAWLAGALLGLS
GAVAQGLFRNPLADPYLLGSASGAALGGALAMALFGLSPGASQWLARLGVTGMAFLGAVAAVLLTLVLARGVQHTLRLLL
AGVIVGVVLGAARDLVELASPEILQAMQAFTLGSTSFVGWIACGLMAGAWALSAGTAWVLARALDGLVLGEATAASLGLP
LAPMRAGLVAAMALATGTAVAQTGLIAFVGLAAPHLVRSIAPSTHQRHVVLSSLMGAVLLLAADILARWIVAPQELPVGV
LTAALGGSYLLWLMHRRARLGRGG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=38.6986301369863, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790740, Length=286, Percent_Identity=37.7622377622378, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=37.6306620209059, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1786347, Length=327, Percent_Identity=30.5810397553517, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790741, Length=285, Percent_Identity=32.6315789473684, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786804, Length=291, Percent_Identity=35.3951890034364, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34417; Mature: 34417

Theoretical pI: Translated: 12.00; Mature: 12.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAGDGAGHAGGARRAAWLAAGLLLAGTALVMLGASVGSTGIGLAWGPDADPVARQILR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
DIRLPRTLGAWLAGALLGLSGAVAQGLFRNPLADPYLLGSASGAALGGALAMALFGLSPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCC
ASQWLARLGVTGMAFLGAVAAVLLTLVLARGVQHTLRLLLAGVIVGVVLGAARDLVELAS
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEILQAMQAFTLGSTSFVGWIACGLMAGAWALSAGTAWVLARALDGLVLGEATAASLGLP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
LAPMRAGLVAAMALATGTAVAQTGLIAFVGLAAPHLVRSIAPSTHQRHVVLSSLMGAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAADILARWIVAPQELPVGVLTAALGGSYLLWLMHRRARLGRGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRPAGDGAGHAGGARRAAWLAAGLLLAGTALVMLGASVGSTGIGLAWGPDADPVARQILR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
DIRLPRTLGAWLAGALLGLSGAVAQGLFRNPLADPYLLGSASGAALGGALAMALFGLSPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCC
ASQWLARLGVTGMAFLGAVAAVLLTLVLARGVQHTLRLLLAGVIVGVVLGAARDLVELAS
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEILQAMQAFTLGSTSFVGWIACGLMAGAWALSAGTAWVLARALDGLVLGEATAASLGLP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
LAPMRAGLVAAMALATGTAVAQTGLIAFVGLAAPHLVRSIAPSTHQRHVVLSSLMGAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAADILARWIVAPQELPVGVLTAALGGSYLLWLMHRRARLGRGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]