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The map label for this gene is qacA [H]

Identifier: 120609413

GI number: 120609413

Start: 772288

End: 773820

Strand: Direct

Name: qacA [H]

Synonym: Aave_0717

Alternate gene names: 120609413

Gene position: 772288-773820 (Clockwise)

Preceding gene: 120609411

Following gene: 120609414

Centisome position: 14.43

GC content: 67.71

Gene sequence:

>1533_bases
ATGAAACATACGATGAAACCGGCTTTGACACCCCTGCGGCGATGGGCCTTGCTCGCCGTCGTGGGCATCGGCCTGCTGAT
GGTGGCACTGGATGTCACCATCCTCTACACAGCGCTGCCGTCGTTGGCGCGCGAACTGCATGCGACCAGTGCGCAGGGGC
TGTGGATCATCAACGCCTATCCGCTGGTGACCGCAGGCCTGCTGCTGGGCGCTGGCACACTGGGCGACCGCATCGGCCAC
CGTTCGATGTACCTGGCCGGCCTGGTGATCTTCGGCGTCGCCTCGTTCATGGCGGCCTTGTCGCCCACAGCTGACGTGTT
GATCGCGGCCCGGGTCTTCCAGGCCATCGGCGCGGCCGCGATGATGCCGGCCACGCTGGCGCTGATCCGCATTGCCTTCG
AGAACGAGCGCGAACGCAATTTGGCGATTTCGGTCTGGGCGAGCCTGTCGCTGGTCGGTGCCGTGCTCGGCCCGCTGCTT
GGCGGGGTGTTGCTGCAGCACTACTGGTGGGGCGCGATCTTCCTGATCAACCTGCCAATTGTCGTTCTGGCCATCGCAGG
CACCTGGTTGGTGGCACCTCGGCACAATCGACTGCACGATGGCGTGGCCCGCCCGTGGGATGGCGTGTCCTCGTTGCAGG
TGTTGGTGGTGTTGTCTGCGCTAGTGGCCGCGATCAAGGAATGCGCCGCGCCTCAGCCATCGTGGCCACTGGCACTGGCG
CTGCTGGTCATGAGCGCAGGGGCTGCGGCACTGTTCATTCGCCGGCAGTCCCGGCTGGCGTATCCGCTGCTTGACTTCTC
GCTGTTCCGCAATCCGGCCTTCACGGCGGGCGTGCTGGCCGCCGCCTTCGTGACCTTCGCCACGGGCGGCCTGCTACTGA
GCATCGCCCAGCGTTTTCAGTGGGTGGCGGGGTTCACGCCGCTGCAGGCAGGGCTGCTGGTGTCGGCGATCTTTCTGGGT
ACGCTGCCCAGCGGCTTGCTGGGTGGGGCCTTCCTGCATCGGGTCGGCCTGCGCTGGCTGCTTTCGGGTGGCTTGGCCGT
GGGGGGGCTGGGTGTGCTGCTGGCGGTGTTCGGACAGCCGTTCGGCCTGGTCTGGCTGGTCACCGGCCTGGTGGTGGCTG
GCAGCGGTCTTGGCGCCACGATCTCGGTGGCCTCCACTGCCATCGTGGGCAATGCGCCCGCGCATCGCGCCGGCATGGCC
GCCTCCGTGGAGGAAGTCGCCTACGAGTTCGGCAGCCTGTTCGCCGTTGCGGTACTGGGCAGCCTGCTGGCGGGCCTGTA
CTCGGCCACGGTGCAACTCCCCCCTGACGCGCCCGAGGCGGCACGCCAGGGCATGGCCGAGGCGCTGGAAATCGCCAAGG
GCGCAGGGGCCGCTGGGGGTGCACTGTTCGAGGCCGCGGCCCAAGCATTCGAGCATGCCTACCAGTGGGTGATGGTGGTC
GCTGCCGTGTTGCTGTTCATCGGTGCGCTGGTGACGGCACGCTTGCTGCGCTGCTACGGCCCAGGCACCGCGTCGGCCTC
GGCAGTGCACTGA

Upstream 100 bases:

>100_bases
CGTTGGCTGCTTGCTTGGACTGGCGTACGCAGTTCGCCGGGCTTAACAGGCGCATTGCATCTACGGCTCCTGCGCCGACT
GCTCAGCAGAAAGAGGACAC

Downstream 100 bases:

>100_bases
TCGCATGAGGCATCCCTGATGGCTATCCGCTTAACGCTTCAACCCTGGCTGTTTCTTCTGGCGGCCGTCGCTTCAGAGGT
CGTAGGTGTGACCACGATGA

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKHTMKPALTPLRRWALLAVVGIGLLMVALDVTILYTALPSLARELHATSAQGLWIINAYPLVTAGLLLGAGTLGDRIGH
RSMYLAGLVIFGVASFMAALSPTADVLIAARVFQAIGAAAMMPATLALIRIAFENERERNLAISVWASLSLVGAVLGPLL
GGVLLQHYWWGAIFLINLPIVVLAIAGTWLVAPRHNRLHDGVARPWDGVSSLQVLVVLSALVAAIKECAAPQPSWPLALA
LLVMSAGAAALFIRRQSRLAYPLLDFSLFRNPAFTAGVLAAAFVTFATGGLLLSIAQRFQWVAGFTPLQAGLLVSAIFLG
TLPSGLLGGAFLHRVGLRWLLSGGLAVGGLGVLLAVFGQPFGLVWLVTGLVVAGSGLGATISVASTAIVGNAPAHRAGMA
ASVEEVAYEFGSLFAVAVLGSLLAGLYSATVQLPPDAPEAARQGMAEALEIAKGAGAAGGALFEAAAQAFEHAYQWVMVV
AAVLLFIGALVTARLLRCYGPGTASASAVH

Sequences:

>Translated_510_residues
MKHTMKPALTPLRRWALLAVVGIGLLMVALDVTILYTALPSLARELHATSAQGLWIINAYPLVTAGLLLGAGTLGDRIGH
RSMYLAGLVIFGVASFMAALSPTADVLIAARVFQAIGAAAMMPATLALIRIAFENERERNLAISVWASLSLVGAVLGPLL
GGVLLQHYWWGAIFLINLPIVVLAIAGTWLVAPRHNRLHDGVARPWDGVSSLQVLVVLSALVAAIKECAAPQPSWPLALA
LLVMSAGAAALFIRRQSRLAYPLLDFSLFRNPAFTAGVLAAAFVTFATGGLLLSIAQRFQWVAGFTPLQAGLLVSAIFLG
TLPSGLLGGAFLHRVGLRWLLSGGLAVGGLGVLLAVFGQPFGLVWLVTGLVVAGSGLGATISVASTAIVGNAPAHRAGMA
ASVEEVAYEFGSLFAVAVLGSLLAGLYSATVQLPPDAPEAARQGMAEALEIAKGAGAAGGALFEAAAQAFEHAYQWVMVV
AAVLLFIGALVTARLLRCYGPGTASASAVH
>Mature_510_residues
MKHTMKPALTPLRRWALLAVVGIGLLMVALDVTILYTALPSLARELHATSAQGLWIINAYPLVTAGLLLGAGTLGDRIGH
RSMYLAGLVIFGVASFMAALSPTADVLIAARVFQAIGAAAMMPATLALIRIAFENERERNLAISVWASLSLVGAVLGPLL
GGVLLQHYWWGAIFLINLPIVVLAIAGTWLVAPRHNRLHDGVARPWDGVSSLQVLVVLSALVAAIKECAAPQPSWPLALA
LLVMSAGAAALFIRRQSRLAYPLLDFSLFRNPAFTAGVLAAAFVTFATGGLLLSIAQRFQWVAGFTPLQAGLLVSAIFLG
TLPSGLLGGAFLHRVGLRWLLSGGLAVGGLGVLLAVFGQPFGLVWLVTGLVVAGSGLGATISVASTAIVGNAPAHRAGMA
ASVEEVAYEFGSLFAVAVLGSLLAGLYSATVQLPPDAPEAARQGMAEALEIAKGAGAAGGALFEAAAQAFEHAYQWVMVV
AAVLLFIGALVTARLLRCYGPGTASASAVH

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=408, Percent_Identity=30.8823529411765, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790195, Length=409, Percent_Identity=30.5623471882641, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789042, Length=326, Percent_Identity=27.6073619631902, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788710, Length=336, Percent_Identity=26.7857142857143, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=335, Percent_Identity=31.9402985074627, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790146, Length=136, Percent_Identity=27.9411764705882, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=380, Percent_Identity=22.8947368421053, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=186, Percent_Identity=31.1827956989247, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52699; Mature: 52699

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTMKPALTPLRRWALLAVVGIGLLMVALDVTILYTALPSLARELHATSAQGLWIINAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECH
PLVTAGLLLGAGTLGDRIGHRSMYLAGLVIFGVASFMAALSPTADVLIAARVFQAIGAAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MMPATLALIRIAFENERERNLAISVWASLSLVGAVLGPLLGGVLLQHYWWGAIFLINLPI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLAIAGTWLVAPRHNRLHDGVARPWDGVSSLQVLVVLSALVAAIKECAAPQPSWPLALA
HHHHHHHHHEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLVMSAGAAALFIRRQSRLAYPLLDFSLFRNPAFTAGVLAAAFVTFATGGLLLSIAQRFQ
HHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVAGFTPLQAGLLVSAIFLGTLPSGLLGGAFLHRVGLRWLLSGGLAVGGLGVLLAVFGQP
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
FGLVWLVTGLVVAGSGLGATISVASTAIVGNAPAHRAGMAASVEEVAYEFGSLFAVAVLG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHH
SLLAGLYSATVQLPPDAPEAARQGMAEALEIAKGAGAAGGALFEAAAQAFEHAYQWVMVV
HHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AAVLLFIGALVTARLLRCYGPGTASASAVH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKHTMKPALTPLRRWALLAVVGIGLLMVALDVTILYTALPSLARELHATSAQGLWIINAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECH
PLVTAGLLLGAGTLGDRIGHRSMYLAGLVIFGVASFMAALSPTADVLIAARVFQAIGAAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MMPATLALIRIAFENERERNLAISVWASLSLVGAVLGPLLGGVLLQHYWWGAIFLINLPI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLAIAGTWLVAPRHNRLHDGVARPWDGVSSLQVLVVLSALVAAIKECAAPQPSWPLALA
HHHHHHHHHEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLVMSAGAAALFIRRQSRLAYPLLDFSLFRNPAFTAGVLAAAFVTFATGGLLLSIAQRFQ
HHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVAGFTPLQAGLLVSAIFLGTLPSGLLGGAFLHRVGLRWLLSGGLAVGGLGVLLAVFGQP
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
FGLVWLVTGLVVAGSGLGATISVASTAIVGNAPAHRAGMAASVEEVAYEFGSLFAVAVLG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHH
SLLAGLYSATVQLPPDAPEAARQGMAEALEIAKGAGAAGGALFEAAAQAFEHAYQWVMVV
HHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AAVLLFIGALVTARLLRCYGPGTASASAVH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]