Click here to switch to the map view.

The map label for this gene is yeaE [H]

Identifier: 120609411

GI number: 120609411

Start: 770050

End: 770898

Strand: Direct

Name: yeaE [H]

Synonym: Aave_0715

Alternate gene names: 120609411

Gene position: 770050-770898 (Clockwise)

Preceding gene: 120609410

Following gene: 120609413

Centisome position: 14.39

GC content: 63.25

Gene sequence:

>849_bases
ATGACACAGGGCATTCCGACCCTCACATTGCCATCAGGCCAAGCCGTGCCGGTTCTGGGCCAGGGCACCTGGCACATGGG
CGATGTCAACGCCTCCCTCGGTCAGGAAATCGCCAGCCTGCGCCATGGGCTCGACCTGGGCATGACACTGATCGACACTG
CCGAGATGTACGGCGATGGTGCCTCCGAGCGCGTTGTTGGCGAAGCCATCCATGCACGCCGTGAGCGGGCTTTCGTCGTC
AGCAAGGTACTGCCACAGCATGCCACGCCACAGGGGATTCGTGCGGCCTGCGAGCGCAGTCTGCGCCACCTCGGTATTGA
GCAGATCGACCTCTACTTGTTGCACTGGCGCGAGGACGGGACGTCACTGGCGGATGTGGTCGTTACCTTTGAGGCGTTGA
AAGCCGAAGGCCGAATATCCGCCTGGGGTGTATCCAACTTCGACGTCCCGGACATGGAAGATCTGCTGGCGGTTCCCGGC
GGCGATCAGGTCGCAGTCAACCAAGTTCTCTACAACCTGTCTCGCCGTGGCATCGAGTTTGACTTGCTGCCCTGGTGCCT
GGCGCGCGGGATCGGAGTCATGGCCTACTCGCCACTGGACGAAGGTCGGCTGCTGCACCATAAAGAACTGGCACGCTTTG
CGCAGGCCCGCGGCCTGACTGCAGCGCAAGTGGCGCTGGCGTTCGTGCTGGCGCGCCGTGGGGTCATCGCCATCCCGAAG
GCGGGAGCCGCCGGCCATACCCGCGACAACCGCGATGCGCTGTCGATCCGCTTCGGTGCCTCGGATCTCGCACAGCTCGA
TGCGCTGTTCCCTCCGCCGCAATGCAAGATGCCGTTTGAGATGATTTAG

Upstream 100 bases:

>100_bases
TGGGGTTTGTCGAGGTCAAGCGCATGCGCTACCTGAACGACGAGTACGAGAAACTGGTTTTTGACATGACGCAGGCCAAT
ACACCGCAGGGATACGCCAC

Downstream 100 bases:

>100_bases
CCCGATGGCCATGCCGCCGTACGGCGCCCCCTGGTACGAAAGGTGCACCCAAGGGCAAGTGATCCAGCTCATCACCGCTT
CCCCTCATCAATTCGCGAGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTQGIPTLTLPSGQAVPVLGQGTWHMGDVNASLGQEIASLRHGLDLGMTLIDTAEMYGDGASERVVGEAIHARRERAFVV
SKVLPQHATPQGIRAACERSLRHLGIEQIDLYLLHWREDGTSLADVVVTFEALKAEGRISAWGVSNFDVPDMEDLLAVPG
GDQVAVNQVLYNLSRRGIEFDLLPWCLARGIGVMAYSPLDEGRLLHHKELARFAQARGLTAAQVALAFVLARRGVIAIPK
AGAAGHTRDNRDALSIRFGASDLAQLDALFPPPQCKMPFEMI

Sequences:

>Translated_282_residues
MTQGIPTLTLPSGQAVPVLGQGTWHMGDVNASLGQEIASLRHGLDLGMTLIDTAEMYGDGASERVVGEAIHARRERAFVV
SKVLPQHATPQGIRAACERSLRHLGIEQIDLYLLHWREDGTSLADVVVTFEALKAEGRISAWGVSNFDVPDMEDLLAVPG
GDQVAVNQVLYNLSRRGIEFDLLPWCLARGIGVMAYSPLDEGRLLHHKELARFAQARGLTAAQVALAFVLARRGVIAIPK
AGAAGHTRDNRDALSIRFGASDLAQLDALFPPPQCKMPFEMI
>Mature_281_residues
TQGIPTLTLPSGQAVPVLGQGTWHMGDVNASLGQEIASLRHGLDLGMTLIDTAEMYGDGASERVVGEAIHARRERAFVVS
KVLPQHATPQGIRAACERSLRHLGIEQIDLYLLHWREDGTSLADVVVTFEALKAEGRISAWGVSNFDVPDMEDLLAVPGG
DQVAVNQVLYNLSRRGIEFDLLPWCLARGIGVMAYSPLDEGRLLHHKELARFAQARGLTAAQVALAFVLARRGVIAIPKA
GAAGHTRDNRDALSIRFGASDLAQLDALFPPPQCKMPFEMI

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24497577, Length=301, Percent_Identity=29.9003322259136, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5174391, Length=301, Percent_Identity=29.9003322259136, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=29.3918918918919, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI5453543, Length=311, Percent_Identity=29.2604501607717, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310109920, Length=311, Percent_Identity=29.2604501607717, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI24497583, Length=305, Percent_Identity=29.5081967213115, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=27.3333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=29.6774193548387, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=29.6774193548387, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310109922, Length=292, Percent_Identity=29.1095890410959, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=28.7822878228782, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI24497585, Length=304, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI300116273, Length=281, Percent_Identity=28.4697508896797, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4502049, Length=296, Percent_Identity=28.3783783783784, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI41327764, Length=170, Percent_Identity=31.1764705882353, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788081, Length=273, Percent_Identity=47.6190476190476, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=28.4615384615385, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788070, Length=301, Percent_Identity=28.9036544850498, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081735, Length=275, Percent_Identity=27.6363636363636, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082198, Length=273, Percent_Identity=28.9377289377289, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789375, Length=314, Percent_Identity=27.0700636942675, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787674, Length=252, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994888, Length=213, Percent_Identity=31.4553990610329, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789199, Length=346, Percent_Identity=26.3005780346821, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=27.0967741935484, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71998625, Length=281, Percent_Identity=24.5551601423488, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17552492, Length=283, Percent_Identity=28.6219081272085, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=25.8278145695364, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17566692, Length=309, Percent_Identity=25.8899676375405, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561298, Length=283, Percent_Identity=27.208480565371, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=288, Percent_Identity=26.0416666666667, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=257, Percent_Identity=26.4591439688716, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537077, Length=306, Percent_Identity=23.8562091503268, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=306, Percent_Identity=23.8562091503268, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=28.125, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320576, Length=270, Percent_Identity=30.7407407407407, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322556, Length=272, Percent_Identity=25.3676470588235, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644950, Length=307, Percent_Identity=29.3159609120521, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24663317, Length=301, Percent_Identity=26.9102990033223, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45553081, Length=299, Percent_Identity=26.4214046822742, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662789, Length=284, Percent_Identity=30.2816901408451, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129731, Length=309, Percent_Identity=29.126213592233, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24657054, Length=284, Percent_Identity=26.4084507042254, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=25.8687258687259, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356425, Length=309, Percent_Identity=26.2135922330097, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24662781, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24662785, Length=223, Percent_Identity=29.1479820627803, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30529; Mature: 30398

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGIPTLTLPSGQAVPVLGQGTWHMGDVNASLGQEIASLRHGLDLGMTLIDTAEMYGDG
CCCCCCEEECCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCHHHCHHHHHHHHHHCCC
ASERVVGEAIHARRERAFVVSKVLPQHATPQGIRAACERSLRHLGIEQIDLYLLHWREDG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHEEEEEEEECCCC
TSLADVVVTFEALKAEGRISAWGVSNFDVPDMEDLLAVPGGDQVAVNQVLYNLSRRGIEF
CHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
DLLPWCLARGIGVMAYSPLDEGRLLHHKELARFAQARGLTAAQVALAFVLARRGVIAIPK
CHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECC
AGAAGHTRDNRDALSIRFGASDLAQLDALFPPPQCKMPFEMI
CCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQGIPTLTLPSGQAVPVLGQGTWHMGDVNASLGQEIASLRHGLDLGMTLIDTAEMYGDG
CCCCCEEECCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCHHHCHHHHHHHHHHCCC
ASERVVGEAIHARRERAFVVSKVLPQHATPQGIRAACERSLRHLGIEQIDLYLLHWREDG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHEEEEEEEECCCC
TSLADVVVTFEALKAEGRISAWGVSNFDVPDMEDLLAVPGGDQVAVNQVLYNLSRRGIEF
CHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
DLLPWCLARGIGVMAYSPLDEGRLLHHKELARFAQARGLTAAQVALAFVLARRGVIAIPK
CHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECC
AGAAGHTRDNRDALSIRFGASDLAQLDALFPPPQCKMPFEMI
CCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]