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The map label for this gene is Hgd [H]

Identifier: 120609197

GI number: 120609197

Start: 533574

End: 534461

Strand: Reverse

Name: Hgd [H]

Synonym: Aave_0495

Alternate gene names: 120609197

Gene position: 534461-533574 (Counterclockwise)

Preceding gene: 120609198

Following gene: 120609196

Centisome position: 9.98

GC content: 63.63

Gene sequence:

>888_bases
ATGCGGATCGGGTTGGTGGGCGCCGGGAACATCGGCAAGCATTTTGCGGCGCGATGGGCAGCCGCTGGGCATTGCGTCTC
GGTGTACGACACCTGCAAGAAGGCCAGGAGCCATGCAGCGAGCATGGGCGCAATACCAGCGGCCGATCTCGGCGGGCTGA
TCGCCAACCAGGACGCGATTGCGCTGAGCCTTCCCACGCCAGAAGTCGTCGTCGATGTTGCGCAGGCTATCGCAGACTTG
GCCCGCGTCCACACAGTGCGTCTCATCGTGGATTTGTCAACGACGGGCGCGGACGCCACCGTCCGTGTGGACACGATGCT
GAAACAGGCAGGGGTGCCATTCTTCTCTGCGCCCGTGAGCGGTGGCACCGTCGCAGCCGCGGAGGGACAGCTGACGGTGA
TGGCGGCGGGCCCGCTGCCGGGCTGGGAACGAGCCATGCCGATGTTCGACGCCATTGCGCGGCATACGTTCTACCTCGGA
CCGAACATACGGCTCGGCCAAACTCTCAAGCTCATCAACAACACGTTGTACGCGGCATGCATGCTCGCCAGTTGCGAGGC
TCTCGTGTGCGGGACGAAAGCAGGGATCGAGGCGCATACCCTGCTGAACGTCATCAACCGCTCCAGTGGGCGCTGTTTCG
CGACGATGGAGCGCCTGCCCAACGCACTGGACCGCAGCTTCCCTCTTCGCTTCAAGACCTCGCTACTGCGCAAAGACGTG
CATTTGGCGCTCATGGCCGCAGACGAACTTGGTGTCCCTATGCAAGTCAGCAAGGCCGCTTTGCGGCTACTTGACGACGC
CATGGTCGCAGGCCTCGGCGAGGCCGACAACATCACTGCCATCCGGGTCGTCGAGCGCCATGCCGGCGTCGTTTTCGGCG
AGTTGTGA

Upstream 100 bases:

>100_bases
ATGCGTTAACTCGACAGTCATACCCTCAAAACGATTTTGCAATCGATGGATTCCGTGCTGCGGCATAGCATTTCATCCAG
AAGTCATTCGGGAGGAAGCT

Downstream 100 bases:

>100_bases
CATTGCCCTGCCCAAAGCGGATGCTCGCGGCACCCTACACAAGAACACCAGATCATCGAGGAGAAAACCATGAAACGAAA
GATCGTCGCTGCACTCGTCG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRIGLVGAGNIGKHFAARWAAAGHCVSVYDTCKKARSHAASMGAIPAADLGGLIANQDAIALSLPTPEVVVDVAQAIADL
ARVHTVRLIVDLSTTGADATVRVDTMLKQAGVPFFSAPVSGGTVAAAEGQLTVMAAGPLPGWERAMPMFDAIARHTFYLG
PNIRLGQTLKLINNTLYAACMLASCEALVCGTKAGIEAHTLLNVINRSSGRCFATMERLPNALDRSFPLRFKTSLLRKDV
HLALMAADELGVPMQVSKAALRLLDDAMVAGLGEADNITAIRVVERHAGVVFGEL

Sequences:

>Translated_295_residues
MRIGLVGAGNIGKHFAARWAAAGHCVSVYDTCKKARSHAASMGAIPAADLGGLIANQDAIALSLPTPEVVVDVAQAIADL
ARVHTVRLIVDLSTTGADATVRVDTMLKQAGVPFFSAPVSGGTVAAAEGQLTVMAAGPLPGWERAMPMFDAIARHTFYLG
PNIRLGQTLKLINNTLYAACMLASCEALVCGTKAGIEAHTLLNVINRSSGRCFATMERLPNALDRSFPLRFKTSLLRKDV
HLALMAADELGVPMQVSKAALRLLDDAMVAGLGEADNITAIRVVERHAGVVFGEL
>Mature_295_residues
MRIGLVGAGNIGKHFAARWAAAGHCVSVYDTCKKARSHAASMGAIPAADLGGLIANQDAIALSLPTPEVVVDVAQAIADL
ARVHTVRLIVDLSTTGADATVRVDTMLKQAGVPFFSAPVSGGTVAAAEGQLTVMAAGPLPGWERAMPMFDAIARHTFYLG
PNIRLGQTLKLINNTLYAACMLASCEALVCGTKAGIEAHTLLNVINRSSGRCFATMERLPNALDRSFPLRFKTSLLRKDV
HLALMAADELGVPMQVSKAALRLLDDAMVAGLGEADNITAIRVVERHAGVVFGEL

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=264, Percent_Identity=28.030303030303, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=25.0883392226148, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=27.8571428571429, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=27.3356401384083, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=27.0175438596491, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=26.4604810996564, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557316, Length=261, Percent_Identity=27.9693486590038, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24655230, Length=282, Percent_Identity=28.0141843971631, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922568, Length=282, Percent_Identity=28.0141843971631, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30963; Mature: 30963

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLVGAGNIGKHFAARWAAAGHCVSVYDTCKKARSHAASMGAIPAADLGGLIANQDAI
CEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCEEECCCEE
ALSLPTPEVVVDVAQAIADLARVHTVRLIVDLSTTGADATVRVDTMLKQAGVPFFSAPVS
EEECCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEHHHHHHHHCCCEEECCCC
GGTVAAAEGQLTVMAAGPLPGWERAMPMFDAIARHTFYLGPNIRLGQTLKLINNTLYAAC
CCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
MLASCEALVCGTKAGIEAHTLLNVINRSSGRCFATMERLPNALDRSFPLRFKTSLLRKDV
HHHCCHHEEECCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
HLALMAADELGVPMQVSKAALRLLDDAMVAGLGEADNITAIRVVERHAGVVFGEL
EEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCEEECCC
>Mature Secondary Structure
MRIGLVGAGNIGKHFAARWAAAGHCVSVYDTCKKARSHAASMGAIPAADLGGLIANQDAI
CEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCEEECCCEE
ALSLPTPEVVVDVAQAIADLARVHTVRLIVDLSTTGADATVRVDTMLKQAGVPFFSAPVS
EEECCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEHHHHHHHHCCCEEECCCC
GGTVAAAEGQLTVMAAGPLPGWERAMPMFDAIARHTFYLGPNIRLGQTLKLINNTLYAAC
CCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
MLASCEALVCGTKAGIEAHTLLNVINRSSGRCFATMERLPNALDRSFPLRFKTSLLRKDV
HHHCCHHEEECCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
HLALMAADELGVPMQVSKAALRLLDDAMVAGLGEADNITAIRVVERHAGVVFGEL
EEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA