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The map label for this gene is serS [H]

Identifier: 120598819

GI number: 120598819

Start: 2322206

End: 2323492

Strand: Direct

Name: serS [H]

Synonym: Sputw3181_2005

Alternate gene names: 120598819

Gene position: 2322206-2323492 (Clockwise)

Preceding gene: 120598818

Following gene: 120598820

Centisome position: 49.32

GC content: 45.22

Gene sequence:

>1287_bases
ATGTTAGATCCTAAATTTTTACGCAACGAATTAGCTGTTACCGCGGAGCGATTGGCCACTCGAGGCTTTATTTTAGATGT
CGCTCATCTTACTCAATTAGAAGAAAAACGTAAGTCGTTGCAAGTGGCTACTGAAGAATTGCAAGCGGCGCGTAATGCCA
TCTCTAAATCCATCGGACAAGCCAAAGCCCGCGGTGAAGATGTTGACGCGATCATGGCACAAGTGGGGGATTTAGGCTCT
CAAGTCGATGCTAAAAAATTAGAGCTGGCAGCTGTATTGGAAGAAGTGAATGCGATTGCGATGTCCATGCCTAACCTGCC
AGATGAATCTGCGCCAATTGGTGCCGATGAAACACAGAATGTCGAAGTACGCCGTTGGGGCACACCACGTAGTTTTGATT
TCCCGATCAAAGATCATATTGACTTGGGCGAAGGCTTAAACGGTTTAGATTTTAAAAGCGCGGTTAAGATCACCGGCTCT
CGTTTTATCGTAATGAAAGGCCAAATCGCCCGATTAAATCGCGCCTTAGGTCAGTTTATGTTGGATCTGCATACGACTGA
GCACGGTTATACCGAAGCCTATGTGCCATTGCTGGTTAATGAAGCGAGTTTACTTGGCACAGGCCAATTGCCGAAGTTTG
GTGAAGACTTATTCCATACCAAACCCGCCACCGAAGAAGGTCAAGGGTTAAGTTTGATCCCTACAGCAGAAGTGCCACTC
ACTAACTTAGTGCGTGACAGTATAGTCGATGAAGACGAGTTACCGATTAAGCTAACAGCACATACCGCATGTTTCCGAAG
CGAAGCAGGATCATACGGCAAAGATACCCGTGGTCTTATTCGTCAGCATCAATTCGATAAAGTTGAACTCGTTCAATTAG
TCAAACCAGAAGACTCAATGGCTGCACTTGAAACGCTGACAAATCATGCCGAAACTGTACTGCAACGCTTAGGACTACCA
TATCGTACAGTTGTGTTATGTACGGGTGATATGGGTTTTGGCTCAAGCAAGACTTATGACATCGAAGTCTGGTTACCAGG
ACAAAATACCTACCGTGAAATTTCTTCTTGCTCAAACATGAAGGATTTCCAAGCCCGCCGTATGCAAGCGCGTTACCGTG
TTAAAGCGGATAATAAACCCGCTTTGTTACACACATTAAATGGCTCTGGTTTGGCTGTTGGCCGTACCTTAGTGGCGATA
TTAGAAAACTATCAGAATGCTGATGGCAGTGTGACTATACCAGAAGCATTGCGTTCTTATATGGGTGGGTTAACTCAAAT
CGGTTAA

Upstream 100 bases:

>100_bases
GATTTTGAATGTGGTGTTGAACCTAAGTTTATGTTTATTTATGGTTTATTTAGGTCAGCAACTGGTTTTTTCACGCATTT
AACTATTAAGAATATATCAC

Downstream 100 bases:

>100_bases
GGTATTCGCGCGACGCTATGGATAAAAGTCAACGTTATCTTCGTTGGCTTTCCTATACAGCAATTATCGCTGTATTTTGT
GCAGTGATGCTGGCAACTGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQAKARGEDVDAIMAQVGDLGS
QVDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQNVEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALETLTNHAETVLQRLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRSYMGGLTQIG

Sequences:

>Translated_428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQAKARGEDVDAIMAQVGDLGS
QVDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQNVEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALETLTNHAETVLQRLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRSYMGGLTQIG
>Mature_428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQAKARGEDVDAIMAQVGDLGS
QVDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQNVEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALETLTNHAETVLQRLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRSYMGGLTQIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=356, Percent_Identity=35.3932584269663, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=30.5, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=32.4404761904762, Blast_Score=175, Evalue=9e-44,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=68.6046511627907, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=30.8045977011494, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.6969696969697, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=30.8673469387755, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=30.9045226130653, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24581334, Length=349, Percent_Identity=34.3839541547278, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17737985, Length=299, Percent_Identity=35.7859531772575, Blast_Score=164, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46932; Mature: 46932

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGSQVDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQN
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGSRFIVMKGQIARLNRALGQFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCCEEHHHEECCHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHH
AALETLTNHAETVLQRLGLPYRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNM
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSVTIPEALRSY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLTQIG
HCHHHCCC
>Mature Secondary Structure
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQAARNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGSQVDAKKLELAAVLEEVNAIAMSMPNLPDESAPIGADETQN
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRSFDFPIKDHIDLGEGLNGLDFKSAVKITGSRFIVMKGQIARLNRALGQFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCCEEHHHEECCHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHH
AALETLTNHAETVLQRLGLPYRTVVLCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNM
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSVTIPEALRSY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLTQIG
HCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA