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The map label for this gene is arpB [H]

Identifier: 120597959

GI number: 120597959

Start: 1285681

End: 1285902

Strand: Direct

Name: arpB [H]

Synonym: Sputw3181_1135

Alternate gene names: 120597959

Gene position: 1285681-1285902 (Clockwise)

Preceding gene: 120597958

Following gene: 120597960

Centisome position: 27.31

GC content: 40.09

Gene sequence:

>222_bases
TTGCGTCCTATTTTGATGACTTCTCTTGTATTTATTGCTGGTGTGATATCTCTTGTACTAGCTAGTGGTGCTGGAGCAGA
AATGCGTCACGCCATGGGTATTGCAGTGTTTGCCGGTATGCTTGGTGTAACCTTCTTTGGATTACTACTTACGCCGGTGT
TTTACGTTATAGTAAGAAATCTGTCATTAAGAAAAAACGCAGAAAGTATAGTCAATCTTTAG

Upstream 100 bases:

>100_bases
GGCCGCAAAAAATGCCATTTTAATCGTTGATTTTGCAAGGACTCAGGAGAATTAGTGACGATCACCGCTTGGGGCCGTAC
TCGAGGCAGCGTACTTACGT

Downstream 100 bases:

>100_bases
TGAAAAGATATCAGAGTGAAATGAGTTTAGACCTTGACCTTACAACAGTGGAAAGCCCTACAATCAGAAGTACTCAAACC
AAACTGGAGGTATATAAATG

Product: hydrophobe/amphiphile efflux-1 HAE1

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 73; Mature: 73

Protein sequence:

>73_residues
MRPILMTSLVFIAGVISLVLASGAGAEMRHAMGIAVFAGMLGVTFFGLLLTPVFYVIVRNLSLRKNAESIVNL

Sequences:

>Translated_73_residues
MRPILMTSLVFIAGVISLVLASGAGAEMRHAMGIAVFAGMLGVTFFGLLLTPVFYVIVRNLSLRKNAESIVNL
>Mature_73_residues
MRPILMTSLVFIAGVISLVLASGAGAEMRHAMGIAVFAGMLGVTFFGLLLTPVFYVIVRNLSLRKNAESIVNL

Specific function: The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in or

COG id: COG0841

COG function: function code V; Cation/multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1788814, Length=59, Percent_Identity=45.7627118644068, Blast_Score=59, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036
- InterPro:   IPR004764 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 7781; Mature: 7781

Theoretical pI: Translated: 11.36; Mature: 11.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPILMTSLVFIAGVISLVLASGAGAEMRHAMGIAVFAGMLGVTFFGLLLTPVFYVIVRN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLRKNAESIVNL
HHHHCCHHHHHCC
>Mature Secondary Structure
MRPILMTSLVFIAGVISLVLASGAGAEMRHAMGIAVFAGMLGVTFFGLLLTPVFYVIVRN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLRKNAESIVNL
HHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]