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The map label for this gene is pth [H]

Identifier: 120597881

GI number: 120597881

Start: 1195264

End: 1195890

Strand: Direct

Name: pth [H]

Synonym: Sputw3181_1051

Alternate gene names: 120597881

Gene position: 1195264-1195890 (Clockwise)

Preceding gene: 120597880

Following gene: 120597882

Centisome position: 25.39

GC content: 44.18

Gene sequence:

>627_bases
ATGCTGGTTGCCATCGACCAAATAACGATTTTGAGTGTCATGAGCGAAATAAAATTAATAGTGGGCCTTGCTAATCCGGG
GGCCGAATATGCTCAGACCCGCCATAATGCGGGCGCTTGGTATGTTCAAGAGTTAGCTCGAATTTGCGGCGTAACATTAG
TCCCTGACAGCAAATATTTTGGCTTAACCGCCAGAGCGGTACTACAGGGTAAAGATGTTCGCTTGTTGATCCCAACGACG
TATATGAACTTAAGTGGTAAAGCCGTAGGTGCTTTGGCTAATTTTTTTCGTATCACGCCTGAAGAAATTTTAGTCGCCCA
CGATGAGCTTGATATGCCGCCTGGTGTCGCTAAATTTAAGTTGGGTGGTGGCCATGGCGGCCACAATGGTTTAAAGGATA
TTATTGCTAAATTGGCTAACGATAAAAATTTTTATCGTTTACGCATAGGTATTGGTCACCCCGGCGATAAAAACCAAGTC
AGTGGTTACGTACTCGGTAAAGCACCTGCGAAAGAGCAAGAGCTTATTGAGGCCGCTATTGATGAGGCGGTACGTTCCAC
TGAAATTTTATATAAAGAAAACATGGTTAAAGCCATGACTAGATTACACTCCTTCAAAGCGGAGTAG

Upstream 100 bases:

>100_bases
TGGCTTTTCCCCAACAGAAGTACACGGCATTTGTTGACTTTGGCTTTGAGTGCTAAAATGCCGCGTTTTTAGCAGCTATG
GCCAGCACTGATGATATTTT

Downstream 100 bases:

>100_bases
AGTGATATTTGGCAAAATGCCGAATGTCACTATAACAGTTTTATGATTCAGTCATGTGTTGCCATTGGGTAGCACAACTA
AAACTCGCTGGTGAGTGTGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLVAIDQITILSVMSEIKLIVGLANPGAEYAQTRHNAGAWYVQELARICGVTLVPDSKYFGLTARAVLQGKDVRLLIPTT
YMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNQV
SGYVLGKAPAKEQELIEAAIDEAVRSTEILYKENMVKAMTRLHSFKAE

Sequences:

>Translated_208_residues
MLVAIDQITILSVMSEIKLIVGLANPGAEYAQTRHNAGAWYVQELARICGVTLVPDSKYFGLTARAVLQGKDVRLLIPTT
YMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNQV
SGYVLGKAPAKEQELIEAAIDEAVRSTEILYKENMVKAMTRLHSFKAE
>Mature_208_residues
MLVAIDQITILSVMSEIKLIVGLANPGAEYAQTRHNAGAWYVQELARICGVTLVPDSKYFGLTARAVLQGKDVRLLIPTT
YMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNQV
SGYVLGKAPAKEQELIEAAIDEAVRSTEILYKENMVKAMTRLHSFKAE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=38.6904761904762, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=70.3125, Blast_Score=263, Evalue=6e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22641; Mature: 22641

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVAIDQITILSVMSEIKLIVGLANPGAEYAQTRHNAGAWYVQELARICGVTLVPDSKYF
CEEEEHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCC
GLTARAVLQGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFK
CHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHEEECCCCCCCCCCEEEE
LGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNQVSGYVLGKAPAKEQELIEAAI
ECCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEAVRSTEILYKENMVKAMTRLHSFKAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVAIDQITILSVMSEIKLIVGLANPGAEYAQTRHNAGAWYVQELARICGVTLVPDSKYF
CEEEEHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCC
GLTARAVLQGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFK
CHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHEEECCCCCCCCCCEEEE
LGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNQVSGYVLGKAPAKEQELIEAAI
ECCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEAVRSTEILYKENMVKAMTRLHSFKAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA