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The map label for this gene is murC

Identifier: 120597222

GI number: 120597222

Start: 423078

End: 424544

Strand: Direct

Name: murC

Synonym: Sputw3181_0391

Alternate gene names: 120597222

Gene position: 423078-424544 (Clockwise)

Preceding gene: 120597221

Following gene: 120597223

Centisome position: 8.99

GC content: 48.67

Gene sequence:

>1467_bases
ATGACTAAAACAGAAAGATACATACAGCTAAGAAGCATGATCCCCGAAATGCGCCGTATTAAGCGTATTCACTTCGTCGG
CATTGGCGGCGCGGGCATGGGCGGGATAGCTGAAGTGTTAGTGAACGAAGGCTATCAGGTGAGTGGTTCGGATATCGCCC
AAAATACCGTGACTGACAGATTGTGTTTACTCGGTGCGAAGATCCAAATTGGTCATGCTGCTGACAATGTACAGCAAGTT
GATGTTGTTGTGGTTTCGACCGCGATAAACGCTGAAAATCCTGAAATTATCGCCGCTAAAGAGTTACGGATCCCTATCGT
TCGCCGTGCCGAAATGCTGGCGGAGTTAATGCGTTATCGCCATGGTGTGGCGATTGCGGGCACCCATGGTAAAACTACCA
CAACCAGTCTTATTGCCAGTGTCTATGGGCAAGCAGGGCGAGATCCCACTTTTGTTATTGGTGGCTTACTTAATAGCGCA
GGTACTAATGCAAGATTGGGCACCAGTCGTTACTTGATTGCCGAAGCTGATGAAAGTGATGCAAGCTTCCTGCATCTGCA
GCCTATGGTCAGCGTGGTAACCAATATTGAAGCCGATCATATGGATACCTATGGCGGTGACTTTGAAAAACTGAAATCGA
CCTTTGTGGATTTTCTGCATAATTTGCCATTCTATGGTGTGGCAGTCGTGTGTATTGATGATCCTGTTGTTCGTGAAATT
ATGCCGCGTATTGGTCGTCACTTAGTGACTTATGGTTTTAGTGATGACGCTGATGTTCAAGCATTAAACTTTAGCCAGCA
AGGCCATCAATGCCGTTTTACGGTAAGACGCAAAGGTAAGGAAGATTTAGATCTGCTGCTTAACCTGCCAGGTCAGCACA
ATGTGCTAAATGCGCTGGCTGCGATTGCGGTAGCAACCGAAGATGAAATTGATGACAGCGCCCTTATTCAAGCCCTAGCT
GAGTTCCAAGGCATTGGTCGTCGTTTCCAGCATTTAGGTAAGTTTGCCACACCTAAGGGTGAAGTGATGTTAGTTGATGA
CTATGGTCATCACCCAAGTGAAGTGGCTGCAACCATTAAAGCAGCACGAGCAGGCTGGCCAGAAAAACGCTTAGTCATGG
CCTATCAGCCCCATCGATATACACGTACCCGTGATTTGTACGAAGACTTTATTGAGGTGTTATCTCAGGTGGATTGCCTG
CTGTTACTCGATGTCTACAGTGCAGGCGAGGCACCCATTACCGGTGCCGATGGTCGGGCATTGTGCCGCTCGATTCGTCT
TCGCGGCCAGCTTGATCCCATCTTTATTGCCAGCCCAGATCAGCTAGCCGAAGTGCTACCCGATGTGTTGCAGGAGGGGG
ATTTATTGTTGACCCAAGGTGCGGGTAATATAGGCGCCCTGTCGCGCCAGTTAGCGGTAACAGAATTAGGCTTTGCAAAG
GTAGAAATCGCGCAGGTGCCAGCGTGA

Upstream 100 bases:

>100_bases
AATTAGCCCGTATGGGCCAAAGAGCAAGAGACGTTGCAGTACTGGATGCCACAGAACAAGTTGCAGCCGTGTGCATTAGC
CTTGCTGAGAAAGGATAAGC

Downstream 100 bases:

>100_bases
TGTATGGTGTTTGGACTGTGGTTAAAAGGAAATTTTGACCAAAAGGTTTCGCTCTATATAATGGCCGGTTTTCTGTGGTT
TTTGGTAAGTGTCGTTAAAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDRLCLLGAKIQIGHAADNVQQV
DVVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSA
GTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREI
MPRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALAAIAVATEDEIDDSALIQALA
EFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCL
LLLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAK
VEIAQVPA

Sequences:

>Translated_488_residues
MTKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDRLCLLGAKIQIGHAADNVQQV
DVVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSA
GTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREI
MPRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALAAIAVATEDEIDDSALIQALA
EFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCL
LLLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAK
VEIAQVPA
>Mature_487_residues
TKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDRLCLLGAKIQIGHAADNVQQVD
VVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAG
TNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREIM
PRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALAAIAVATEDEIDDSALIQALAE
FQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCLL
LLDVYSAGEAPITGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAKV
EIAQVPA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=65.3444676409186, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=27.5268817204301, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53191; Mature: 53059

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDR
CCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHHH
LCLLGAKIQIGHAADNVQQVDVVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYR
HHHHCCEEEECCCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
HGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESD
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREI
CCEEEHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHH
MPRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALA
HHHHHHHEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHEEECCCCHHHHHHHH
AIAVATEDEIDDSALIQALAEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIK
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCLLLLDVYSAGEAPITGADGRA
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCHHH
LCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAK
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEE
VEIAQVPA
EEEECCCC
>Mature Secondary Structure 
TKTERYIQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIAQNTVTDR
CCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHHH
LCLLGAKIQIGHAADNVQQVDVVVVSTAINAENPEIIAAKELRIPIVRRAEMLAELMRYR
HHHHCCEEEECCCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
HGVAIAGTHGKTTTTSLIASVYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESD
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDPVVREI
CCEEEHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHH
MPRIGRHLVTYGFSDDADVQALNFSQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALA
HHHHHHHEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHEEECCCCHHHHHHHH
AIAVATEDEIDDSALIQALAEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIK
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPEKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCLLLLDVYSAGEAPITGADGRA
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCHHH
LCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAVTELGFAK
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEE
VEIAQVPA
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA