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The map label for this gene is mtr [H]

Identifier: 120596970

GI number: 120596970

Start: 165648

End: 166904

Strand: Direct

Name: mtr [H]

Synonym: Sputw3181_0137

Alternate gene names: 120596970

Gene position: 165648-166904 (Clockwise)

Preceding gene: 120596969

Following gene: 120596972

Centisome position: 3.52

GC content: 45.35

Gene sequence:

>1257_bases
ATGACAAATCATATGAATGCGGTTAAGCATAAAACCGCAGGTAAGTCTTTGCTCGGTGGCGCCATGATTATTGCTGGGAC
GACCGTAGGGGCGGGCATGTTTTCCTTACCTGTGGTGGGTTCTGGCATGTGGTTTGGGTATTCCATTGTCATGCTGCTAG
GTATTTGGTTTTGCATGTTGATGTCGGGCTTATTACTGCTTGAAACCAACTTACACTTTGAACCTGGTGCGAGTTTCGAT
ACGTTAACAAAACAAACCTTAGGCCAGTTTTGGCGCATAGTGAATGGCGTGTCAATCGCCTTTGTGCTCTACATTTTAAC
CTATGCCTATATCAGCGGTGGTGGCTCGATTGTAAATCACAGCTTGCAGGGTATGGGGATTGAATTACCTCAAAGTGTGG
CAGGGTTAGTATTTGCCATAGTGCTAGCGAGTATTGTGCTGATCAGCACCAAAGCTGTGGATCGTATTACAACGATAATG
CTGGGCGGTATGATCATCACTTTCTTTCTTGCTATCGGTAATTTACTGATAGAGATTGACGTCACTAAGCTGCTTGAGCC
CGATGGTACCACAAGATTTGCACCTTATTTGTGGGCAGCGTTGCCCTTTGGCCTTGCTAGCTTTGGCTATCATGGCAATG
TGCCTAGTTTAGTGAAGTATTACGGTAAAGATTCCGCCACTATTATCAAAGCTATCTTTGTCGGTACTTTTATCGCGCTT
ATCATTTATGCCTGTTGGTTAGTCGCCACTATGGGCAATATTCCCCGCAGCCAGTTTAGCGATATTATCGCCCAAGGCGG
CAATATGGGTGTGTTGGTTGGTGCTTTGTCTAAGGTGATGGCAAGTAGCTGGTTAAACAGTATGTTAACCCTGTTTGCAA
ACTTAGCGGTGGCCTCGTCGTTCCTCGGTGTAACTTTGGGTTTGTTTGATTATCTTGCAGACTTATTTGGTTTTGATGAC
TCCCGTAATGGAAGGATAAAAACGGCTGCTGTTACTTTTGTTCCTCCGACGGTCTTTGGGCTGTTATTTCCTGATGGTTT
TTTGATTGCTATTGGTTTTGCGGCATTGGCGGCAACGGTTTGGGCTGTGATTGTGCCTGCGCTGATGGCTTATAAGTCTC
GGCAGTTATTCCCTGAAAGTACAGGTTTTAAAGTGAAGGGAGGTACACCCATTATCGTCATCGTCGTCTTATTTGGAATC
ATCACAGGTACGTGTCATCTTTTGGCAATGGCGAATTTGCTGCCTCAGTATTCCTAG

Upstream 100 bases:

>100_bases
AATCTGATGTTAAGCGTATTCGAGATCAAGCCAATAGCCTATTGAGAGCCTCAGTGAGACAGACGATAGTTGCGAGTGTC
ACTGCGGAGCATATTAGTTA

Downstream 100 bases:

>100_bases
TCCATTTTACTAATAAAGCCCTCGTTTAAATGAGGGCTTTTGTGTTTTTGACGATTCCATCTTGGCTCTTATAAATCTGT
ATTTAGCTGCTTAATTGGAG

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTNHMNAVKHKTAGKSLLGGAMIIAGTTVGAGMFSLPVVGSGMWFGYSIVMLLGIWFCMLMSGLLLLETNLHFEPGASFD
TLTKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIM
LGGMIITFFLAIGNLLIEIDVTKLLEPDGTTRFAPYLWAALPFGLASFGYHGNVPSLVKYYGKDSATIIKAIFVGTFIAL
IIYACWLVATMGNIPRSQFSDIIAQGGNMGVLVGALSKVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDD
SRNGRIKTAAVTFVPPTVFGLLFPDGFLIAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFKVKGGTPIIVIVVLFGI
ITGTCHLLAMANLLPQYS

Sequences:

>Translated_418_residues
MTNHMNAVKHKTAGKSLLGGAMIIAGTTVGAGMFSLPVVGSGMWFGYSIVMLLGIWFCMLMSGLLLLETNLHFEPGASFD
TLTKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIM
LGGMIITFFLAIGNLLIEIDVTKLLEPDGTTRFAPYLWAALPFGLASFGYHGNVPSLVKYYGKDSATIIKAIFVGTFIAL
IIYACWLVATMGNIPRSQFSDIIAQGGNMGVLVGALSKVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDD
SRNGRIKTAAVTFVPPTVFGLLFPDGFLIAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFKVKGGTPIIVIVVLFGI
ITGTCHLLAMANLLPQYS
>Mature_417_residues
TNHMNAVKHKTAGKSLLGGAMIIAGTTVGAGMFSLPVVGSGMWFGYSIVMLLGIWFCMLMSGLLLLETNLHFEPGASFDT
LTKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIML
GGMIITFFLAIGNLLIEIDVTKLLEPDGTTRFAPYLWAALPFGLASFGYHGNVPSLVKYYGKDSATIIKAIFVGTFIALI
IYACWLVATMGNIPRSQFSDIIAQGGNMGVLVGALSKVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDDS
RNGRIKTAAVTFVPPTVFGLLFPDGFLIAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFKVKGGTPIIVIVVLFGII
TGTCHLLAMANLLPQYS

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=387, Percent_Identity=57.8811369509044, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1790145, Length=407, Percent_Identity=46.6830466830467, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1788218, Length=410, Percent_Identity=37.3170731707317, Blast_Score=252, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44495; Mature: 44363

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHMNAVKHKTAGKSLLGGAMIIAGTTVGAGMFSLPVVGSGMWFGYSIVMLLGIWFCML
CCCCHHHHHHHHCCHHHHCCCCEEECCHHCCCHHHHCHHCCCHHHHHHHHHHHHHHHHHH
MSGLLLLETNLHFEPGASFDTLTKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNH
HHCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIMLGGMIITFFLAIGNLLIEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTKLLEPDGTTRFAPYLWAALPFGLASFGYHGNVPSLVKYYGKDSATIIKAIFVGTFIAL
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
IIYACWLVATMGNIPRSQFSDIIAQGGNMGVLVGALSKVMASSWLNSMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDDSRNGRIKTAAVTFVPPTVFGLLFPDGFLIAIGFAALAATV
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHH
WAVIVPALMAYKSRQLFPESTGFKVKGGTPIIVIVVLFGIITGTCHLLAMANLLPQYS
HHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNHMNAVKHKTAGKSLLGGAMIIAGTTVGAGMFSLPVVGSGMWFGYSIVMLLGIWFCML
CCCHHHHHHHHCCHHHHCCCCEEECCHHCCCHHHHCHHCCCHHHHHHHHHHHHHHHHHH
MSGLLLLETNLHFEPGASFDTLTKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNH
HHCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIMLGGMIITFFLAIGNLLIEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTKLLEPDGTTRFAPYLWAALPFGLASFGYHGNVPSLVKYYGKDSATIIKAIFVGTFIAL
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
IIYACWLVATMGNIPRSQFSDIIAQGGNMGVLVGALSKVMASSWLNSMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDDSRNGRIKTAAVTFVPPTVFGLLFPDGFLIAIGFAALAATV
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHH
WAVIVPALMAYKSRQLFPESTGFKVKGGTPIIVIVVLFGIITGTCHLLAMANLLPQYS
HHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1987112; 2061290; 9278503; 1904443; 7814318 [H]