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The map label for this gene is qor [C]

Identifier: 119947144

GI number: 119947144

Start: 4359880

End: 4360884

Strand: Direct

Name: qor [C]

Synonym: Ping_3542

Alternate gene names: 119947144

Gene position: 4359880-4360884 (Clockwise)

Preceding gene: 119947141

Following gene: 119947149

Centisome position: 95.62

GC content: 43.28

Gene sequence:

>1005_bases
ATGAAAGCAGTTGCTTACCAAAATTCACAACCTATTACCCATCCTCAGGCTTTAATTGATGTCGACCTTCCAAAGCCGGT
CGCCAGTGGCACTGATATATTAGTCAATGTTGAAGCTATTTCAGTGAATCCCGTCGATACCAAAGTTCGCAATAACGTCA
CTCCAACCGATCAGCAGTACAAGATATTAGGTTGGGATGCAGTTGGCACGATTGTCTCTATTGGTGAGCAGGTAACCTTA
TTTAAACCCGGCGATAAAGTTTGGTATGCAGGTGCAATCAACCGCCAGGGTGCAAATTGTGAATACCATCTGGTTGATCA
AAGAATTGTTGCCTTGGCCCCCAAAAGTTTATCCTGCCGCGAAGCAGCCGCTATGCCGCTGACTTCAATTACAGCATGGG
AAATATTATTTGATCGCTTTAATCTTAATAGTGAGAGTAAAGGAACACTATTAATTATTGGCGCAGCCGGCGGTGTGGGC
TCAATCATGATTCAACTTGCAAAACAGCTCACCAATCTAACTGTTATTGCCACAGCATCAAGACCGGAAACACAAAGTTG
GGTTAGGGAGTTAGGTGCCGACCATGTGATTAATCACCGTCAGGATTTAGAACAGGAACTGCTGTCAATTGGTCTGGACA
ATGTAAATTACATTGCCAGTCTTACCCATACGGAAGATCATTTCGCGGAAATAGCGACAATTATCGCCCCGCAGGGAAAA
TTAGCAGTGATCGATGATGCGGCGACCCTTGATATTATGCCGCTTAAGCGTAAGAGCGTCTCTGTTCATTGGGAACTGAT
GTTTACCCGCTCACTCTTTGAAACAGAGGATATGATTGAGCAGCATAAATTATTAACCCGCGTTGCCAACATGGTGGATC
AGGGGAAATTAAAATCGACTGTTGCAAATGATTTTGGAACAATCAATGCCGCGAATCTTATCAAGGCGCATGCTTTATTA
GAATCGGAAAAATCCAAGGGGAAAATAGTATTATATGGTTTTTAA

Upstream 100 bases:

>100_bases
AACGCTGTTAATATATACCCAAGTAGTTTGGATATATAGCCAAACGACTGGATATGCATCCTCAAATAGCTTGGCAATAT
AACTAAAAAAGGAAGTCTAT

Downstream 100 bases:

>100_bases
AAAAGACTATCAGCAGGTGTTTATATTTTCACAGGTTTACCTGCGGAGACTAAGTTAATTACGCTTAAAATGCCTCTGAA
TTTTTTCAGAGGCTAAAAGC

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKAVAYQNSQPITHPQALIDVDLPKPVASGTDILVNVEAISVNPVDTKVRNNVTPTDQQYKILGWDAVGTIVSIGEQVTL
FKPGDKVWYAGAINRQGANCEYHLVDQRIVALAPKSLSCREAAAMPLTSITAWEILFDRFNLNSESKGTLLIIGAAGGVG
SIMIQLAKQLTNLTVIATASRPETQSWVRELGADHVINHRQDLEQELLSIGLDNVNYIASLTHTEDHFAEIATIIAPQGK
LAVIDDAATLDIMPLKRKSVSVHWELMFTRSLFETEDMIEQHKLLTRVANMVDQGKLKSTVANDFGTINAANLIKAHALL
ESEKSKGKIVLYGF

Sequences:

>Translated_334_residues
MKAVAYQNSQPITHPQALIDVDLPKPVASGTDILVNVEAISVNPVDTKVRNNVTPTDQQYKILGWDAVGTIVSIGEQVTL
FKPGDKVWYAGAINRQGANCEYHLVDQRIVALAPKSLSCREAAAMPLTSITAWEILFDRFNLNSESKGTLLIIGAAGGVG
SIMIQLAKQLTNLTVIATASRPETQSWVRELGADHVINHRQDLEQELLSIGLDNVNYIASLTHTEDHFAEIATIIAPQGK
LAVIDDAATLDIMPLKRKSVSVHWELMFTRSLFETEDMIEQHKLLTRVANMVDQGKLKSTVANDFGTINAANLIKAHALL
ESEKSKGKIVLYGF
>Mature_334_residues
MKAVAYQNSQPITHPQALIDVDLPKPVASGTDILVNVEAISVNPVDTKVRNNVTPTDQQYKILGWDAVGTIVSIGEQVTL
FKPGDKVWYAGAINRQGANCEYHLVDQRIVALAPKSLSCREAAAMPLTSITAWEILFDRFNLNSESKGTLLIIGAAGGVG
SIMIQLAKQLTNLTVIATASRPETQSWVRELGADHVINHRQDLEQELLSIGLDNVNYIASLTHTEDHFAEIATIIAPQGK
LAVIDDAATLDIMPLKRKSVSVHWELMFTRSLFETEDMIEQHKLLTRVANMVDQGKLKSTVANDFGTINAANLIKAHALL
ESEKSKGKIVLYGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=332, Percent_Identity=28.3132530120482, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194239674, Length=251, Percent_Identity=27.0916334661355, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13236495, Length=251, Percent_Identity=27.0916334661355, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194239676, Length=192, Percent_Identity=30.7291666666667, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI18379349, Length=179, Percent_Identity=31.8435754189944, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI24308257, Length=197, Percent_Identity=26.9035532994924, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=197, Percent_Identity=30.4568527918782, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=248, Percent_Identity=29.4354838709677, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=177, Percent_Identity=28.2485875706215, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=194, Percent_Identity=31.4432989690722, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323493, Length=262, Percent_Identity=24.4274809160305, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319945, Length=276, Percent_Identity=24.2753623188406, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36544; Mature: 36544

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVAYQNSQPITHPQALIDVDLPKPVASGTDILVNVEAISVNPVDTKVRNNVTPTDQQY
CCCEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCCCE
KILGWDAVGTIVSIGEQVTLFKPGDKVWYAGAINRQGANCEYHLVDQRIVALAPKSLSCR
EEEEHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCEEEEECCEEEEECCCCCCCH
EAAAMPLTSITAWEILFDRFNLNSESKGTLLIIGAAGGVGSIMIQLAKQLTNLTVIATAS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECC
RPETQSWVRELGADHVINHRQDLEQELLSIGLDNVNYIASLTHTEDHFAEIATIIAPQGK
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCC
LAVIDDAATLDIMPLKRKSVSVHWELMFTRSLFETEDMIEQHKLLTRVANMVDQGKLKST
EEEEECCCEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VANDFGTINAANLIKAHALLESEKSKGKIVLYGF
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MKAVAYQNSQPITHPQALIDVDLPKPVASGTDILVNVEAISVNPVDTKVRNNVTPTDQQY
CCCEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCCCE
KILGWDAVGTIVSIGEQVTLFKPGDKVWYAGAINRQGANCEYHLVDQRIVALAPKSLSCR
EEEEHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCEEEEECCEEEEECCCCCCCH
EAAAMPLTSITAWEILFDRFNLNSESKGTLLIIGAAGGVGSIMIQLAKQLTNLTVIATAS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECC
RPETQSWVRELGADHVINHRQDLEQELLSIGLDNVNYIASLTHTEDHFAEIATIIAPQGK
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCC
LAVIDDAATLDIMPLKRKSVSVHWELMFTRSLFETEDMIEQHKLLTRVANMVDQGKLKST
EEEEECCCEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VANDFGTINAANLIKAHALLESEKSKGKIVLYGF
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA