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The map label for this gene is argD [H]

Identifier: 119946374

GI number: 119946374

Start: 3371308

End: 3372714

Strand: Direct

Name: argD [H]

Synonym: Ping_2748

Alternate gene names: 119946374

Gene position: 3371308-3372714 (Clockwise)

Preceding gene: 119946373

Following gene: 119946375

Centisome position: 73.94

GC content: 43.92

Gene sequence:

>1407_bases
ATGAATAAAGTCATGCCTGATAAGGCACATCTGCGCAGTGAAGGTGATCTAAATACCACAAAAGCCAGGCAAGACTGGCA
ACATAAACAGCAGCATCAACAGACAAAAACACTGCTAAAACGGGATGCCGATGTGTTTTTACATCAAGCTATGTCAACAC
CCTGTTTAAACAGTTTAGCGTCAGCTGAAGGTATTTATATCACCGACAGCAGTGGTCATTCTTATATGGATTTCCACGGT
AATAATGTCCATCAATTAGGTTATGGCCACCCTGTACTGATTGAAAAAGTAACCAAGCAAATAAGTCAATTACCCTTTTC
ACCGCGGCGTTTTACTAATGAAACGGCCATTGAATGCGCTGAAAAGCTCAGTGAGATTTGCGGTGGAGAGTTAAACCGGG
TGTTATTTGCACCCGGTGGCACCTCGGTGATTGGCATGGCATTAAAACTGGCGCGATATATTAGTGGAAATTATAAAGTA
GTTTCCCTTTGGGATTCCTTTCACGGAGCGTCACTGGATGCGATTTCAGTCGGGGGAGAAGCCTGTTTTCGTGAAGGTAT
GGGGCCATTAATGGCAGGCGTTGAGCGTATTCCACCGCCTGTTACCTACCGTGGTGCATTGACCAGTCCCGATGGTAGTG
ATCTGCATTATGCGGATTACCTTGAATATGTAATTGAAAAAGAAGGCGGCATTGGGGCTTTTATTGCAGAAGCCGTGCGA
AATACCGATGTGCAGGTGCCAAGCAAAGCTTACTGGAAACGTATTCGTGAGATTTGTGATAAACATAATGTGTTATTAAT
TATCGATGATATCCCTAACGGCATGGGCCGCAGTGGCCACTGGTTTACTCATCAGGCATTTGATATTGAACCCGATATTC
TTTGTATCGGCAAAGGCTTAGGGGGCGGATTAGTACCGATGGCCGCCATGATAACCAAAGATAAATACAATACCGCTACC
CATATTTCTCTGGGGCATTATACCCATGAGAAAAGCCCTATTGGTTGCGCAGCGGCACTTGCTACCATCCAAATCATTGA
ACAGGAGCAACTGCTCAGTCAAGTTAAGCTGCATAGTTTATATATTGAGCAGCGTTTATTAAAGCTTAAAGAAAATCACC
CTTTGATTGGTGATATCCGCGGCATTGGTTTGCTCTGGGCGGTAGAATTAGTGACCGATAGAAACACTAAAACCCGCGCA
TTTGATCAAGCCGAAGCCCTGTTATATGAATGCCTGGCACAAGGGCTTAGCTTTAAAATATCTCAGGGTAATGTGATCCA
GCTCAGCCCCCCGCTTATTATCAGCCACACACAATTACAGAATGCACTTGATCTCTTTGAACAAGCCCTTAAAAATATAA
CTCAGGATTCACATTATGAAGAATGCCATGAACAGCACCATAAATAA

Upstream 100 bases:

>100_bases
CCGATTGTTTCCGTATTGGCAATATTGGCGAGGTTTATCCTGAAGATATTGATAAGCTAATGATTGCCATAAAAAATGTT
ATTTACTGGCAAGTCGCTGC

Downstream 100 bases:

>100_bases
CGACATAAATAACGACATAAATAACGACATAAATAACGACATAAATAACACACAATCAAACTCCCCTATTGAAGCAGTTA
TCTTTGACTGGGCCGGTACT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNKVMPDKAHLRSEGDLNTTKARQDWQHKQQHQQTKTLLKRDADVFLHQAMSTPCLNSLASAEGIYITDSSGHSYMDFHG
NNVHQLGYGHPVLIEKVTKQISQLPFSPRRFTNETAIECAEKLSEICGGELNRVLFAPGGTSVIGMALKLARYISGNYKV
VSLWDSFHGASLDAISVGGEACFREGMGPLMAGVERIPPPVTYRGALTSPDGSDLHYADYLEYVIEKEGGIGAFIAEAVR
NTDVQVPSKAYWKRIREICDKHNVLLIIDDIPNGMGRSGHWFTHQAFDIEPDILCIGKGLGGGLVPMAAMITKDKYNTAT
HISLGHYTHEKSPIGCAAALATIQIIEQEQLLSQVKLHSLYIEQRLLKLKENHPLIGDIRGIGLLWAVELVTDRNTKTRA
FDQAEALLYECLAQGLSFKISQGNVIQLSPPLIISHTQLQNALDLFEQALKNITQDSHYEECHEQHHK

Sequences:

>Translated_468_residues
MNKVMPDKAHLRSEGDLNTTKARQDWQHKQQHQQTKTLLKRDADVFLHQAMSTPCLNSLASAEGIYITDSSGHSYMDFHG
NNVHQLGYGHPVLIEKVTKQISQLPFSPRRFTNETAIECAEKLSEICGGELNRVLFAPGGTSVIGMALKLARYISGNYKV
VSLWDSFHGASLDAISVGGEACFREGMGPLMAGVERIPPPVTYRGALTSPDGSDLHYADYLEYVIEKEGGIGAFIAEAVR
NTDVQVPSKAYWKRIREICDKHNVLLIIDDIPNGMGRSGHWFTHQAFDIEPDILCIGKGLGGGLVPMAAMITKDKYNTAT
HISLGHYTHEKSPIGCAAALATIQIIEQEQLLSQVKLHSLYIEQRLLKLKENHPLIGDIRGIGLLWAVELVTDRNTKTRA
FDQAEALLYECLAQGLSFKISQGNVIQLSPPLIISHTQLQNALDLFEQALKNITQDSHYEECHEQHHK
>Mature_468_residues
MNKVMPDKAHLRSEGDLNTTKARQDWQHKQQHQQTKTLLKRDADVFLHQAMSTPCLNSLASAEGIYITDSSGHSYMDFHG
NNVHQLGYGHPVLIEKVTKQISQLPFSPRRFTNETAIECAEKLSEICGGELNRVLFAPGGTSVIGMALKLARYISGNYKV
VSLWDSFHGASLDAISVGGEACFREGMGPLMAGVERIPPPVTYRGALTSPDGSDLHYADYLEYVIEKEGGIGAFIAEAVR
NTDVQVPSKAYWKRIREICDKHNVLLIIDDIPNGMGRSGHWFTHQAFDIEPDILCIGKGLGGGLVPMAAMITKDKYNTAT
HISLGHYTHEKSPIGCAAALATIQIIEQEQLLSQVKLHSLYIEQRLLKLKENHPLIGDIRGIGLLWAVELVTDRNTKTRA
FDQAEALLYECLAQGLSFKISQGNVIQLSPPLIISHTQLQNALDLFEQALKNITQDSHYEECHEQHHK

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=31.2649164677804, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4557809, Length=411, Percent_Identity=27.7372262773723, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=31.1224489795918, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=30.3102625298329, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=30.1020408163265, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI13994255, Length=420, Percent_Identity=26.1904761904762, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=28.0405405405405, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=29.3233082706767, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=28.428927680798, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=27.7777777777778, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=26.3414634146341, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=27.75, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=26.5258215962441, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=24.2774566473988, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=27.972027972028, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=26.036866359447, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=26.7772511848341, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=26.0869565217391, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=29.0953545232274, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=26.980198019802, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21357415, Length=410, Percent_Identity=28.2926829268293, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI161085790, Length=414, Percent_Identity=26.5700483091787, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=27.6849642004773, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574759, Length=413, Percent_Identity=26.1501210653753, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 51950; Mature: 51950

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVMPDKAHLRSEGDLNTTKARQDWQHKQQHQQTKTLLKRDADVFLHQAMSTPCLNSLA
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SAEGIYITDSSGHSYMDFHGNNVHQLGYGHPVLIEKVTKQISQLPFSPRRFTNETAIECA
CCCCEEEECCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHH
EKLSEICGGELNRVLFAPGGTSVIGMALKLARYISGNYKVVSLWDSFHGASLDAISVGGE
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCHH
ACFREGMGPLMAGVERIPPPVTYRGALTSPDGSDLHYADYLEYVIEKEGGIGAFIAEAVR
HHHHHCCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
NTDVQVPSKAYWKRIREICDKHNVLLIIDDIPNGMGRSGHWFTHQAFDIEPDILCIGKGL
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEECCC
GGGLVPMAAMITKDKYNTATHISLGHYTHEKSPIGCAAALATIQIIEQEQLLSQVKLHSL
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YIEQRLLKLKENHPLIGDIRGIGLLWAVELVTDRNTKTRAFDQAEALLYECLAQGLSFKI
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEE
SQGNVIQLSPPLIISHTQLQNALDLFEQALKNITQDSHYEECHEQHHK
CCCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNKVMPDKAHLRSEGDLNTTKARQDWQHKQQHQQTKTLLKRDADVFLHQAMSTPCLNSLA
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SAEGIYITDSSGHSYMDFHGNNVHQLGYGHPVLIEKVTKQISQLPFSPRRFTNETAIECA
CCCCEEEECCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHH
EKLSEICGGELNRVLFAPGGTSVIGMALKLARYISGNYKVVSLWDSFHGASLDAISVGGE
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCHH
ACFREGMGPLMAGVERIPPPVTYRGALTSPDGSDLHYADYLEYVIEKEGGIGAFIAEAVR
HHHHHCCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
NTDVQVPSKAYWKRIREICDKHNVLLIIDDIPNGMGRSGHWFTHQAFDIEPDILCIGKGL
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEECCC
GGGLVPMAAMITKDKYNTATHISLGHYTHEKSPIGCAAALATIQIIEQEQLLSQVKLHSL
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YIEQRLLKLKENHPLIGDIRGIGLLWAVELVTDRNTKTRAFDQAEALLYECLAQGLSFKI
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEE
SQGNVIQLSPPLIISHTQLQNALDLFEQALKNITQDSHYEECHEQHHK
CCCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]