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The map label for this gene is pepQ [H]

Identifier: 119946185

GI number: 119946185

Start: 3111428

End: 3113227

Strand: Direct

Name: pepQ [H]

Synonym: Ping_2545

Alternate gene names: 119946185

Gene position: 3111428-3113227 (Clockwise)

Preceding gene: 119946176

Following gene: 119946187

Centisome position: 68.24

GC content: 44.56

Gene sequence:

>1800_bases
TTGCCTCAAACAATCGCACAAAAACTGACAACAATCCGCGCGCACATGGAAGAGGCCAATTTAGATGCCTTTATTATTCC
CCGTGCCGACGAATACCTCGGTGAACATATTCCCGAACATAACCAACGCCTATTATGGTGTAGTAGCTTCAGTGGTTCAG
CGGGCACTGTTATTATTTTAAAAGACCGTGCAGCGATTTTTGTTGATGGCCGTTATACTATTCAAGTTAAGCAACAGGTC
AATACTGAGTTATTTGAATTTTATGATCTGCATGAAACCCCGCATATAGCCTGGTTAAGTCAGCAATTACCGGTGCAAGC
CAATGTTGGGTATGATCCCAAAGTCCACAACCTGAACTGGCACAATGCCAGTGTTAATACGCTGTCTAAACAGCACATAA
ATCTGCTTGCGGTCCAAGAAAATTTAGTCGACCTGAGTTGGTCGGGGAGGCCGCTACCCACAACTAATATAGGATTACTG
CTGGATGAACAATATACCGGCCAGCCAAGTTTAGAAAAACGCCAACAAATTGGTGCTGATATTGCGAAAAAAGGGGCTGA
TGCAGTGATCATTAATGCCTTAGATTCTATTGCCTGGTTATTAAATATTCGCGGTAAAGACATCCACTGCTTCTGCGTGA
TCTTAGGCTCGGCTATCTTATATAAAGATGGTTCTCTCACGTTTTTAACTAACCCGGCCAAGATCCCTGCCGGTTTCCAC
GACCATGTAGGCGCAGGCGTCGACATTATTGATGAGTCACAATCGACAGCAACCTACCAAGCATTAGGCGAACAAAAACT
CCAGGTACTCGCTGATCCAGAAACCTGCAATGCATTTTTTCAACTTACCGCACAACAAGCAGGTGCGACATTAATCGCCG
GCGATGATCCGGTCGCATTACCAAAAGCCTGTAAAAATATCACTGAACTCGCGGGTATGCGCGCGGCACATATTCGTGAT
GGCGCCTCAGAAGTACGTTTTCTCGCGTGGTTAGCAGCAGAAGTTGCCGCCGAGTGTTTGCATGATGAAATCACTTTGTC
GAATAAACTAGCCAGTTTCCGAGCCAGTAATGAACATTTTGTGGAACTGAGTTTTGATACAATTTCAGCCGCAGGTGCTA
ACGCTGCGATGTGCCATTACAACCCTGCCAATGGCGTACCGGCAGTACTTGCGATGGATAGTATTTACCTGTTTGATTCT
GGCGGCCAATACCTTGACGGGACCACGGATATTACCCGCACTGTCGCGATTGGTACACCGAGTGCTGAACATAAAAAAAT
GTTTACCTTAGTGCTAAAAGGTCACATATCCCTCGCGCAAATGAAATTCCCAATGGGCACTAATGGTGGCCAACTCGATT
CACTGGCTCGTCAGTTTTTATGGCAGGAAGGTTATGATTATGAGCATGGTACAGGGCATGGTGTGGGGAGTTTTTTAAAC
GTCCATGAAGGCCCGCAGCGTATAGGTAAAAAGAATAGCGCAGTGCCCTTAATGCCGGGAATGATCGTCTCCAATGAGCC
GGGTTATTATAAACAAGATGAATATGGTATTCGTTGTGAAAATCTCGTTTCCGTGGTTAACAAAGATAATGGCCATGACG
GGAAAACATTCTATGAGTTTGAAACCTTAACCTTGGTTCCTTTTGATTTGCATCTTATTGATCAAAAACTATTAAACCCA
AATGAAGTCAACTGGCTTAATAATTACCACCAGCAAGTCTTTAACACTTTATCCCCGCTGTTAGCGGACAGTGATTTACA
GTGGTTATCACAAGCAACCCGCGTCATTAAATTAAACTAA

Upstream 100 bases:

>100_bases
GTATATCCATTCTTCCTAGCAACTCTTGTATATCTAAAGCCAAACAGGTTAGAGTCTTATTATTAGCTAGTATTATCCTT
TAAAATAAACGGAGCCTAAC

Downstream 100 bases:

>100_bases
ATTAAGGCCTAAACCATTGGTACAACAAGGTGTGAGTTCTATTCGATCGTTATTCTCACTTCACAAAATCGTCTGGAACG
ATTTTGAACAGCTTCAGCTG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MPQTIAQKLTTIRAHMEEANLDAFIIPRADEYLGEHIPEHNQRLLWCSSFSGSAGTVIILKDRAAIFVDGRYTIQVKQQV
NTELFEFYDLHETPHIAWLSQQLPVQANVGYDPKVHNLNWHNASVNTLSKQHINLLAVQENLVDLSWSGRPLPTTNIGLL
LDEQYTGQPSLEKRQQIGADIAKKGADAVIINALDSIAWLLNIRGKDIHCFCVILGSAILYKDGSLTFLTNPAKIPAGFH
DHVGAGVDIIDESQSTATYQALGEQKLQVLADPETCNAFFQLTAQQAGATLIAGDDPVALPKACKNITELAGMRAAHIRD
GASEVRFLAWLAAEVAAECLHDEITLSNKLASFRASNEHFVELSFDTISAAGANAAMCHYNPANGVPAVLAMDSIYLFDS
GGQYLDGTTDITRTVAIGTPSAEHKKMFTLVLKGHISLAQMKFPMGTNGGQLDSLARQFLWQEGYDYEHGTGHGVGSFLN
VHEGPQRIGKKNSAVPLMPGMIVSNEPGYYKQDEYGIRCENLVSVVNKDNGHDGKTFYEFETLTLVPFDLHLIDQKLLNP
NEVNWLNNYHQQVFNTLSPLLADSDLQWLSQATRVIKLN

Sequences:

>Translated_599_residues
MPQTIAQKLTTIRAHMEEANLDAFIIPRADEYLGEHIPEHNQRLLWCSSFSGSAGTVIILKDRAAIFVDGRYTIQVKQQV
NTELFEFYDLHETPHIAWLSQQLPVQANVGYDPKVHNLNWHNASVNTLSKQHINLLAVQENLVDLSWSGRPLPTTNIGLL
LDEQYTGQPSLEKRQQIGADIAKKGADAVIINALDSIAWLLNIRGKDIHCFCVILGSAILYKDGSLTFLTNPAKIPAGFH
DHVGAGVDIIDESQSTATYQALGEQKLQVLADPETCNAFFQLTAQQAGATLIAGDDPVALPKACKNITELAGMRAAHIRD
GASEVRFLAWLAAEVAAECLHDEITLSNKLASFRASNEHFVELSFDTISAAGANAAMCHYNPANGVPAVLAMDSIYLFDS
GGQYLDGTTDITRTVAIGTPSAEHKKMFTLVLKGHISLAQMKFPMGTNGGQLDSLARQFLWQEGYDYEHGTGHGVGSFLN
VHEGPQRIGKKNSAVPLMPGMIVSNEPGYYKQDEYGIRCENLVSVVNKDNGHDGKTFYEFETLTLVPFDLHLIDQKLLNP
NEVNWLNNYHQQVFNTLSPLLADSDLQWLSQATRVIKLN
>Mature_598_residues
PQTIAQKLTTIRAHMEEANLDAFIIPRADEYLGEHIPEHNQRLLWCSSFSGSAGTVIILKDRAAIFVDGRYTIQVKQQVN
TELFEFYDLHETPHIAWLSQQLPVQANVGYDPKVHNLNWHNASVNTLSKQHINLLAVQENLVDLSWSGRPLPTTNIGLLL
DEQYTGQPSLEKRQQIGADIAKKGADAVIINALDSIAWLLNIRGKDIHCFCVILGSAILYKDGSLTFLTNPAKIPAGFHD
HVGAGVDIIDESQSTATYQALGEQKLQVLADPETCNAFFQLTAQQAGATLIAGDDPVALPKACKNITELAGMRAAHIRDG
ASEVRFLAWLAAEVAAECLHDEITLSNKLASFRASNEHFVELSFDTISAAGANAAMCHYNPANGVPAVLAMDSIYLFDSG
GQYLDGTTDITRTVAIGTPSAEHKKMFTLVLKGHISLAQMKFPMGTNGGQLDSLARQFLWQEGYDYEHGTGHGVGSFLNV
HEGPQRIGKKNSAVPLMPGMIVSNEPGYYKQDEYGIRCENLVSVVNKDNGHDGKTFYEFETLTLVPFDLHLIDQKLLNPN
EVNWLNNYHQQVFNTLSPLLADSDLQWLSQATRVIKLN

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI93141226, Length=611, Percent_Identity=35.0245499181669, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI264681563, Length=619, Percent_Identity=36.5105008077544, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI264681565, Length=619, Percent_Identity=34.8949919224556, Blast_Score=322, Evalue=5e-88,
Organism=Escherichia coli, GI1788728, Length=169, Percent_Identity=33.1360946745562, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=592, Percent_Identity=33.445945945946, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI25149105, Length=626, Percent_Identity=28.7539936102236, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322999, Length=650, Percent_Identity=32.7692307692308, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI17137632, Length=621, Percent_Identity=36.0708534621578, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI161078230, Length=609, Percent_Identity=31.0344827586207, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI21357287, Length=609, Percent_Identity=31.0344827586207, Blast_Score=281, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65967; Mature: 65836

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTIAQKLTTIRAHMEEANLDAFIIPRADEYLGEHIPEHNQRLLWCSSFSGSAGTVIIL
CCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCEEEEEECCCCCCCEEEEE
KDRAAIFVDGRYTIQVKQQVNTELFEFYDLHETPHIAWLSQQLPVQANVGYDPKVHNLNW
ECCEEEEECCEEEEEEHHHCCHHHHHHHHCCCCCCEEEHHCCCCEEECCCCCCCCCCCCC
HNASVNTLSKQHINLLAVQENLVDLSWSGRPLPTTNIGLLLDEQYTGQPSLEKRQQIGAD
CCCCHHHHHHHCEEEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCHH
IAKKGADAVIINALDSIAWLLNIRGKDIHCFCVILGSAILYKDGSLTFLTNPAKIPAGFH
HHHCCCCEEEEEHHHHHEEHEEECCCCEEEEEEECCCHHEEECCCEEEEECCCCCCCCCH
DHVGAGVDIIDESQSTATYQALGEQKLQVLADPETCNAFFQLTAQQAGATLIAGDDPVAL
HHCCCCCEEEECCCCHHHHHHHCHHCEEEEECCHHHHHHHHEEHHHCCEEEEECCCCCCH
PKACKNITELAGMRAAHIRDGASEVRFLAWLAAEVAAECLHDEITLSNKLASFRASNEHF
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VELSFDTISAAGANAAMCHYNPANGVPAVLAMDSIYLFDSGGQYLDGTTDITRTVAIGTP
EEEEEHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEEECCC
SAEHKKMFTLVLKGHISLAQMKFPMGTNGGQLDSLARQFLWQEGYDYEHGTGHGVGSFLN
CHHHHHEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
VHEGPQRIGKKNSAVPLMPGMIVSNEPGYYKQDEYGIRCENLVSVVNKDNGHDGKTFYEF
CCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEE
ETLTLVPFDLHLIDQKLLNPNEVNWLNNYHQQVFNTLSPLLADSDLQWLSQATRVIKLN
EEEEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEC
>Mature Secondary Structure 
PQTIAQKLTTIRAHMEEANLDAFIIPRADEYLGEHIPEHNQRLLWCSSFSGSAGTVIIL
CHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCEEEEEECCCCCCCEEEEE
KDRAAIFVDGRYTIQVKQQVNTELFEFYDLHETPHIAWLSQQLPVQANVGYDPKVHNLNW
ECCEEEEECCEEEEEEHHHCCHHHHHHHHCCCCCCEEEHHCCCCEEECCCCCCCCCCCCC
HNASVNTLSKQHINLLAVQENLVDLSWSGRPLPTTNIGLLLDEQYTGQPSLEKRQQIGAD
CCCCHHHHHHHCEEEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCHH
IAKKGADAVIINALDSIAWLLNIRGKDIHCFCVILGSAILYKDGSLTFLTNPAKIPAGFH
HHHCCCCEEEEEHHHHHEEHEEECCCCEEEEEEECCCHHEEECCCEEEEECCCCCCCCCH
DHVGAGVDIIDESQSTATYQALGEQKLQVLADPETCNAFFQLTAQQAGATLIAGDDPVAL
HHCCCCCEEEECCCCHHHHHHHCHHCEEEEECCHHHHHHHHEEHHHCCEEEEECCCCCCH
PKACKNITELAGMRAAHIRDGASEVRFLAWLAAEVAAECLHDEITLSNKLASFRASNEHF
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VELSFDTISAAGANAAMCHYNPANGVPAVLAMDSIYLFDSGGQYLDGTTDITRTVAIGTP
EEEEEHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEEECCC
SAEHKKMFTLVLKGHISLAQMKFPMGTNGGQLDSLARQFLWQEGYDYEHGTGHGVGSFLN
CHHHHHEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
VHEGPQRIGKKNSAVPLMPGMIVSNEPGYYKQDEYGIRCENLVSVVNKDNGHDGKTFYEF
CCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEE
ETLTLVPFDLHLIDQKLLNPNEVNWLNNYHQQVFNTLSPLLADSDLQWLSQATRVIKLN
EEEEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]