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The map label for this gene is upp

Identifier: 119945343

GI number: 119945343

Start: 1986264

End: 1986890

Strand: Direct

Name: upp

Synonym: Ping_1628

Alternate gene names: 119945343

Gene position: 1986264-1986890 (Clockwise)

Preceding gene: 119945342

Following gene: 119945344

Centisome position: 43.56

GC content: 39.55

Gene sequence:

>627_bases
ATGAAAGTAATTGAAGTAAAGCATCCGCTGATTCAACACAAAATAGGCTTGATGCGTGAAGCTGACATTAGTACTAAACG
TTTTCGCGAAATAGCGCGCGAAGTTGGCAGTTTACTAACTTATGAAGCGACCAAAAATCTGGAACTTGAAACAGTCAAAA
TTCAAGGTTGGAATGGAGAAGTAGAAGTACAGCAGATTAAAGGTAAAAAAGCGACTGTGGTACCTATCTTGCGTGCTGGT
TTAGGTATGATGGATGGCGTGTTGGAACATATGCCAAGCGCAAAAATTAGTGTTGTTGGTATTTATCGCGATGAAAAAAC
CCTAGAGCCGGTGCCTTATTTTCAAAAATTAGTGAGCAATATTGATGAACGGTTAGCCATTGTTGTTGATCCCATGCTTG
CGACGGGTGGATCTATGATTTCCACCATTGATTTAATCAAAAAAGCTGGGTGTACTAGAATTGTTGTACTTGTTTTAGTG
GCTGCACCAGAAGGTTTAAAAGCATTAGAAGCCGCACATCCTGATCTTGAAGTTTACACCGCGTCTATTGATGATCACTT
AGATGAACAGGGTTATATTGTACCTGGTCTTGGTGATGCTGGTGATAAAATTTTTGGTACAAAATAA

Upstream 100 bases:

>100_bases
TAAAAATGACCGGCTATTATGCCTAAGGTGAGTGACCAAGGCTCCTTGGCCCAGGATCATGTACAAGTAGATTTTTATTT
TATGATTAGGAATGAAGAAT

Downstream 100 bases:

>100_bases
CTAACCAACTAATACCAACTCCACTCATTTTCTATTCATTTATATGCACTAACTGAATGCTAGCCAAGCATAAAACGCTA
TTTTAGTCTTTGTCATTGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKVIEVKHPLIQHKIGLMREADISTKRFREIAREVGSLLTYEATKNLELETVKIQGWNGEVEVQQIKGKKATVVPILRAG
LGMMDGVLEHMPSAKISVVGIYRDEKTLEPVPYFQKLVSNIDERLAIVVDPMLATGGSMISTIDLIKKAGCTRIVVLVLV
AAPEGLKALEAAHPDLEVYTASIDDHLDEQGYIVPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKVIEVKHPLIQHKIGLMREADISTKRFREIAREVGSLLTYEATKNLELETVKIQGWNGEVEVQQIKGKKATVVPILRAG
LGMMDGVLEHMPSAKISVVGIYRDEKTLEPVPYFQKLVSNIDERLAIVVDPMLATGGSMISTIDLIKKAGCTRIVVLVLV
AAPEGLKALEAAHPDLEVYTASIDDHLDEQGYIVPGLGDAGDKIFGTK
>Mature_208_residues
MKVIEVKHPLIQHKIGLMREADISTKRFREIAREVGSLLTYEATKNLELETVKIQGWNGEVEVQQIKGKKATVVPILRAG
LGMMDGVLEHMPSAKISVVGIYRDEKTLEPVPYFQKLVSNIDERLAIVVDPMLATGGSMISTIDLIKKAGCTRIVVLVLV
AAPEGLKALEAAHPDLEVYTASIDDHLDEQGYIVPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=79.3269230769231, Blast_Score=348, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=22.8855721393035, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=22.8855721393035, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=40.5797101449275, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550449, Length=149, Percent_Identity=28.1879194630872, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573516, Length=149, Percent_Identity=28.1879194630872, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573514, Length=149, Percent_Identity=28.1879194630872, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573512, Length=149, Percent_Identity=28.1879194630872, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PSYIN (A1SVA9)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943023.1
- ProteinModelPortal:   A1SVA9
- SMR:   A1SVA9
- STRING:   A1SVA9
- GeneID:   4623858
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1628
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   A1SVA9
- BioCyc:   PING357804:PING_1628-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22740; Mature: 22740

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIEVKHPLIQHKIGLMREADISTKRFREIAREVGSLLTYEATKNLELETVKIQGWNGE
CCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCCC
VEVQQIKGKKATVVPILRAGLGMMDGVLEHMPSAKISVVGIYRDEKTLEPVPYFQKLVSN
EEEEEECCCCCEEHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
IDERLAIVVDPMLATGGSMISTIDLIKKAGCTRIVVLVLVAAPEGLKALEAAHPDLEVYT
HHHHEEEEECHHHHCCCHHHHHHHHHHHCCHHHEEHHHHHHCCCCHHHHHHCCCCCEEEE
ASIDDHLDEQGYIVPGLGDAGDKIFGTK
ECHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKVIEVKHPLIQHKIGLMREADISTKRFREIAREVGSLLTYEATKNLELETVKIQGWNGE
CCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCCC
VEVQQIKGKKATVVPILRAGLGMMDGVLEHMPSAKISVVGIYRDEKTLEPVPYFQKLVSN
EEEEEECCCCCEEHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
IDERLAIVVDPMLATGGSMISTIDLIKKAGCTRIVVLVLVAAPEGLKALEAAHPDLEVYT
HHHHEEEEECHHHHCCCHHHHHHHHHHHCCHHHEEHHHHHHCCCCHHHHHHCCCCCEEEE
ASIDDHLDEQGYIVPGLGDAGDKIFGTK
ECHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA