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The map label for this gene is uraA [H]

Identifier: 119945344

GI number: 119945344

Start: 1987142

End: 1988425

Strand: Direct

Name: uraA [H]

Synonym: Ping_1629

Alternate gene names: 119945344

Gene position: 1987142-1988425 (Clockwise)

Preceding gene: 119945343

Following gene: 119945345

Centisome position: 43.58

GC content: 40.89

Gene sequence:

>1284_bases
ATGACTGCTCGTACCGATTCTGAATTGGGAACACCAGAAAAAGAAATAGTTGAGGACGTGACTGCTGACTTTAATGCATT
TCAGCAAGCCTTGGCTGGATCACAAATGTTATTTGTAGCATTTGGTGCCTTAGTATTAATGCCATTAATCACTGGACTTG
ATCCAAATGTTGCCTTATTTACGGCTGGTATTGGTACTTTATTATTCCATTTAGTGACCAAAGGGAAAGTGCCAATATTT
TTGGCATCTTCATTCGCCTTTATTGCTCCCATTGCTTATGGCATTCAAACCTGGGGAATTCCCGGTACTATGTCGGGATT
ATTTGTAGCTGGCCTTGTTTATATGCTGATGTCATATGCGGTTAAACTTCGTGGTGTTGATTTTATTCATCGCTTATTAC
CGCCTGTTGTTGTTGGACCCGTGATCATGGTGATTGGTTTAAGCCTTGCGCCTGTTGCTGTGAATATGGCACTGGGTAAA
GCGGGTGATGGTAGTTTTGTTTTAATAGAACAAAATACAGCAATGATCATCTCTTTCTCTTCACTTATCTGCACTTTATT
AGTGGCGACTAAAGCGAAAGGCGTTTTTAAATTACTGCCTATTCTCTCAGGGGTCGTGCTTGGCTATAGCCTGTCATTGT
TCTTTGGCGTGGTTGATTTCAGTCCGGTCGGTAATGCAGCTTGGTTGAGTATACCCAACTTTGTCGCGCCGGAATGGAAC
TGGCAAGCTGTCTTATTTATGATTCCGGTGGCAATTGCCCCCGCAGTTGAACATGTTGGCGATATTCTTGCTATTAGTAA
TGTAACGGGTAAAGATTTTTTGAAAAAACCAGGTCTACATCGTACTTTGTTTGGTGATGGTCTGGCGACTAGTGCTGCTT
CATTATTTGGCGGCCCCCCTAATACGACTTATTCAGAGGTAACCGGTGCGGTTATGTTAACCCGTAACTTCAATCCTAAA
ATAATGATTTGGGCTGCTGTTATTGCTATTTTATTAGCTTTTATCGGAAAATTTGGAGCCATATTACAAACTATTCCTTC
GGCTGTGATGGGGGGAATTTTAATCTTATTATTTGGGACTATTGCGTCTGTTGGATTAAATACGTTAATCCGTCATCAAG
TTGATCTCTCCAATTCGCGTAATTTATGCATTGTCTCTGTCGTTTTAGTTTTTGGAATCGGTGGAATGGCTTTTGATTTT
GGTGATTTTAGCCTGCAAGGGGTCAGTTTATGCGCGCTTGTTGCAATATTTCTAAATATGGTTTTACCCAAGACAAAATC
ATAA

Upstream 100 bases:

>100_bases
TTCCCTGCACCCAAATAGACGGCCTAATGAGTGGGATTAGTATAATTTAACCTTATTCTAAAATTGATAGGGTTATTTTT
TGAGTATTATGGAGAAATAG

Downstream 100 bases:

>100_bases
ATTAAATTTTATCACTTTAAAACGTAAGGCAGATTCAACTTTGAAGTGCATAACCACTAAGCAGCTATAGTCACCCTATG
TTCAGCCATTAATTTGGCTG

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTARTDSELGTPEKEIVEDVTADFNAFQQALAGSQMLFVAFGALVLMPLITGLDPNVALFTAGIGTLLFHLVTKGKVPIF
LASSFAFIAPIAYGIQTWGIPGTMSGLFVAGLVYMLMSYAVKLRGVDFIHRLLPPVVVGPVIMVIGLSLAPVAVNMALGK
AGDGSFVLIEQNTAMIISFSSLICTLLVATKAKGVFKLLPILSGVVLGYSLSLFFGVVDFSPVGNAAWLSIPNFVAPEWN
WQAVLFMIPVAIAPAVEHVGDILAISNVTGKDFLKKPGLHRTLFGDGLATSAASLFGGPPNTTYSEVTGAVMLTRNFNPK
IMIWAAVIAILLAFIGKFGAILQTIPSAVMGGILILLFGTIASVGLNTLIRHQVDLSNSRNLCIVSVVLVFGIGGMAFDF
GDFSLQGVSLCALVAIFLNMVLPKTKS

Sequences:

>Translated_427_residues
MTARTDSELGTPEKEIVEDVTADFNAFQQALAGSQMLFVAFGALVLMPLITGLDPNVALFTAGIGTLLFHLVTKGKVPIF
LASSFAFIAPIAYGIQTWGIPGTMSGLFVAGLVYMLMSYAVKLRGVDFIHRLLPPVVVGPVIMVIGLSLAPVAVNMALGK
AGDGSFVLIEQNTAMIISFSSLICTLLVATKAKGVFKLLPILSGVVLGYSLSLFFGVVDFSPVGNAAWLSIPNFVAPEWN
WQAVLFMIPVAIAPAVEHVGDILAISNVTGKDFLKKPGLHRTLFGDGLATSAASLFGGPPNTTYSEVTGAVMLTRNFNPK
IMIWAAVIAILLAFIGKFGAILQTIPSAVMGGILILLFGTIASVGLNTLIRHQVDLSNSRNLCIVSVVLVFGIGGMAFDF
GDFSLQGVSLCALVAIFLNMVLPKTKS
>Mature_426_residues
TARTDSELGTPEKEIVEDVTADFNAFQQALAGSQMLFVAFGALVLMPLITGLDPNVALFTAGIGTLLFHLVTKGKVPIFL
ASSFAFIAPIAYGIQTWGIPGTMSGLFVAGLVYMLMSYAVKLRGVDFIHRLLPPVVVGPVIMVIGLSLAPVAVNMALGKA
GDGSFVLIEQNTAMIISFSSLICTLLVATKAKGVFKLLPILSGVVLGYSLSLFFGVVDFSPVGNAAWLSIPNFVAPEWNW
QAVLFMIPVAIAPAVEHVGDILAISNVTGKDFLKKPGLHRTLFGDGLATSAASLFGGPPNTTYSEVTGAVMLTRNFNPKI
MIWAAVIAILLAFIGKFGAILQTIPSAVMGGILILLFGTIASVGLNTLIRHQVDLSNSRNLCIVSVVLVFGIGGMAFDFG
DFSLQGVSLCALVAIFLNMVLPKTKS

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=437, Percent_Identity=24.7139588100687, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI44680145, Length=435, Percent_Identity=24.5977011494253, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI44680148, Length=392, Percent_Identity=23.7244897959184, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40316845, Length=392, Percent_Identity=23.7244897959184, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=387, Percent_Identity=38.5012919896641, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI87081818, Length=413, Percent_Identity=38.7409200968523, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082181, Length=451, Percent_Identity=28.3813747228381, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790087, Length=379, Percent_Identity=25.5936675461741, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082178, Length=316, Percent_Identity=27.5316455696203, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=215, Percent_Identity=28.8372093023256, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=222, Percent_Identity=24.7747747747748, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=291, Percent_Identity=27.8350515463918, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44984; Mature: 44853

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARTDSELGTPEKEIVEDVTADFNAFQQALAGSQMLFVAFGALVLMPLITGLDPNVALF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
TAGIGTLLFHLVTKGKVPIFLASSFAFIAPIAYGIQTWGIPGTMSGLFVAGLVYMLMSYA
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VKLRGVDFIHRLLPPVVVGPVIMVIGLSLAPVAVNMALGKAGDGSFVLIEQNTAMIISFS
HHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEHH
SLICTLLVATKAKGVFKLLPILSGVVLGYSLSLFFGVVDFSPVGNAAWLSIPNFVAPEWN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
WQAVLFMIPVAIAPAVEHVGDILAISNVTGKDFLKKPGLHRTLFGDGLATSAASLFGGPP
CHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCCCHHHHCCCHHHHHHHHCCCCC
NTTYSEVTGAVMLTRNFNPKIMIWAAVIAILLAFIGKFGAILQTIPSAVMGGILILLFGT
CCCHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASVGLNTLIRHQVDLSNSRNLCIVSVVLVFGIGGMAFDFGDFSLQGVSLCALVAIFLNM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
VLPKTKS
HCCCCCC
>Mature Secondary Structure 
TARTDSELGTPEKEIVEDVTADFNAFQQALAGSQMLFVAFGALVLMPLITGLDPNVALF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
TAGIGTLLFHLVTKGKVPIFLASSFAFIAPIAYGIQTWGIPGTMSGLFVAGLVYMLMSYA
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VKLRGVDFIHRLLPPVVVGPVIMVIGLSLAPVAVNMALGKAGDGSFVLIEQNTAMIISFS
HHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEHH
SLICTLLVATKAKGVFKLLPILSGVVLGYSLSLFFGVVDFSPVGNAAWLSIPNFVAPEWN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
WQAVLFMIPVAIAPAVEHVGDILAISNVTGKDFLKKPGLHRTLFGDGLATSAASLFGGPP
CHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCCCHHHHCCCHHHHHHHHCCCCC
NTTYSEVTGAVMLTRNFNPKIMIWAAVIAILLAFIGKFGAILQTIPSAVMGGILILLFGT
CCCHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASVGLNTLIRHQVDLSNSRNLCIVSVVLVFGIGGMAFDFGDFSLQGVSLCALVAIFLNM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
VLPKTKS
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]