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The map label for this gene is tesB [H]

Identifier: 119945024

GI number: 119945024

Start: 1585657

End: 1586526

Strand: Direct

Name: tesB [H]

Synonym: Ping_1278

Alternate gene names: 119945024

Gene position: 1585657-1586526 (Clockwise)

Preceding gene: 119945023

Following gene: 119945026

Centisome position: 34.78

GC content: 40.46

Gene sequence:

>870_bases
ATGAGTAAAGTACTAAAAGATCTTCTAAGCCAGTTGAATTTAGAAAAACTAGAAGAAAACTTATTCCGTGGTAATAACCA
AGATCTTGGTACTGGTAGAGTTTTTGGCGGACAAGTTATGGGTCAAGCCATTTCAGCTGCCAAAGACACCGTCAGTGAAA
ATAGAAATGTGCATTCTTTTCACTCCTATTTTCTGCTTGCAGGAGAAACTGACAAGCCCATTGTTTATGATGTTGAGCGT
ATTCGTGATGGTAAAAGCCTTTCCACAAGGCGCGTTAAAGCTGTTCAAAATGGCAAAGCTATTTTTTATATGACCGCGTC
TTTTAAAAATAGGGAGCATGGTTTTGAACATCAATTAGAGATGCCCGATGTGCCAAAGCCTGAAGATTTAATTTCAGAAC
AAGAGATGTCATTGCTGCACACGGATACATTACCAGAATCGATACGTGATAAACTTATTTCTGAAAAACCGATAGAGATG
CGGCCTGTCACCTTTGTCAATCCGAGTAATCCTGAGGTTGAGTCTGCTAAACGATTTATTTGGTGCAGAGCCAATGGAAA
AATGCCCGATGATTTACGTATACATCGCTATTTATTAGCATACGCGTCTGATTTCAACTTCCTGCCAACCGCATTACAGC
CCCATGGTGTTTCGTATTTATCGCCTGGTATGCAGGTTGTTACCATCGATCATTCTATGTGGTTTCATCATGATTTCCGT
TTAGATGACTGGTTATTATATGTCGTTGAAAGTCCGGCTGCATCGGATGGATGCGCTCTGGTAAAGGGACACTTTTATAC
AAGAGAGGGAAAATTAGTTGCTTCAACGATTCAGGAAGGCTTGATTCGCCAAAGAAAGGTAAGAGTGTAA

Upstream 100 bases:

>100_bases
TTAGAGCACTATTGATGTCTTTGTAATAGTATTTGTAAATAAAAATAAGATTTGTAAATAAAAAAGGGCGGTTATTAACG
CCCTTTTTTGGGGAGCTAAA

Downstream 100 bases:

>100_bases
ACTAAATAAAAATGGAAGGGACTCACCTTCCTTTTATCCATCTTTAACAAAGGTTTTGATTTAAGTCAGCCTTACATCTC
TATTAGTTATTGGACTTATG

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSKVLKDLLSQLNLEKLEENLFRGNNQDLGTGRVFGGQVMGQAISAAKDTVSENRNVHSFHSYFLLAGETDKPIVYDVER
IRDGKSLSTRRVKAVQNGKAIFYMTASFKNREHGFEHQLEMPDVPKPEDLISEQEMSLLHTDTLPESIRDKLISEKPIEM
RPVTFVNPSNPEVESAKRFIWCRANGKMPDDLRIHRYLLAYASDFNFLPTALQPHGVSYLSPGMQVVTIDHSMWFHHDFR
LDDWLLYVVESPAASDGCALVKGHFYTREGKLVASTIQEGLIRQRKVRV

Sequences:

>Translated_289_residues
MSKVLKDLLSQLNLEKLEENLFRGNNQDLGTGRVFGGQVMGQAISAAKDTVSENRNVHSFHSYFLLAGETDKPIVYDVER
IRDGKSLSTRRVKAVQNGKAIFYMTASFKNREHGFEHQLEMPDVPKPEDLISEQEMSLLHTDTLPESIRDKLISEKPIEM
RPVTFVNPSNPEVESAKRFIWCRANGKMPDDLRIHRYLLAYASDFNFLPTALQPHGVSYLSPGMQVVTIDHSMWFHHDFR
LDDWLLYVVESPAASDGCALVKGHFYTREGKLVASTIQEGLIRQRKVRV
>Mature_288_residues
SKVLKDLLSQLNLEKLEENLFRGNNQDLGTGRVFGGQVMGQAISAAKDTVSENRNVHSFHSYFLLAGETDKPIVYDVERI
RDGKSLSTRRVKAVQNGKAIFYMTASFKNREHGFEHQLEMPDVPKPEDLISEQEMSLLHTDTLPESIRDKLISEKPIEMR
PVTFVNPSNPEVESAKRFIWCRANGKMPDDLRIHRYLLAYASDFNFLPTALQPHGVSYLSPGMQVVTIDHSMWFHHDFRL
DDWLLYVVESPAASDGCALVKGHFYTREGKLVASTIQEGLIRQRKVRV

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=280, Percent_Identity=42.5, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=59.7173144876325, Blast_Score=348, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=39.1156462585034, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17558508, Length=308, Percent_Identity=39.6103896103896, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17531889, Length=286, Percent_Identity=35.6643356643357, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=286, Percent_Identity=35.6643356643357, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=286, Percent_Identity=35.6643356643357, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=31.5436241610738, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI212645202, Length=286, Percent_Identity=31.1188811188811, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32947; Mature: 32816

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLKDLLSQLNLEKLEENLFRGNNQDLGTGRVFGGQVMGQAISAAKDTVSENRNVHSF
CHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCEEEE
HSYFLLAGETDKPIVYDVERIRDGKSLSTRRVKAVQNGKAIFYMTASFKNREHGFEHQLE
EEEEEEECCCCCCEEEEHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
MPDVPKPEDLISEQEMSLLHTDTLPESIRDKLISEKPIEMRPVTFVNPSNPEVESAKRFI
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCHHCCCEEE
WCRANGKMPDDLRIHRYLLAYASDFNFLPTALQPHGVSYLSPGMQVVTIDHSMWFHHDFR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEEEEEECCEEEEECCC
LDDWLLYVVESPAASDGCALVKGHFYTREGKLVASTIQEGLIRQRKVRV
CCCEEEEEEECCCCCCCEEEEECEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKVLKDLLSQLNLEKLEENLFRGNNQDLGTGRVFGGQVMGQAISAAKDTVSENRNVHSF
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCEEEE
HSYFLLAGETDKPIVYDVERIRDGKSLSTRRVKAVQNGKAIFYMTASFKNREHGFEHQLE
EEEEEEECCCCCCEEEEHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
MPDVPKPEDLISEQEMSLLHTDTLPESIRDKLISEKPIEMRPVTFVNPSNPEVESAKRFI
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCHHCCCEEE
WCRANGKMPDDLRIHRYLLAYASDFNFLPTALQPHGVSYLSPGMQVVTIDHSMWFHHDFR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEEEEEECCEEEEECCC
LDDWLLYVVESPAASDGCALVKGHFYTREGKLVASTIQEGLIRQRKVRV
CCCEEEEEEECCCCCCCEEEEECEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]