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The map label for this gene is nadC [H]

Identifier: 119944914

GI number: 119944914

Start: 1449155

End: 1450009

Strand: Reverse

Name: nadC [H]

Synonym: Ping_1158

Alternate gene names: 119944914

Gene position: 1450009-1449155 (Counterclockwise)

Preceding gene: 119944918

Following gene: 119944913

Centisome position: 31.8

GC content: 40.47

Gene sequence:

>855_bases
ATGGTTGCACAAGAAATAATTCGGAGTGTCAAAATCGCGTTAGATGAAGATTTAAACGGCCTCTCTCCACTTGAAGGTGA
TATCTCAGCGAATTTAATCCCTGAAGGTAGACAAGCTAAAGCGATTGTTATAACACGTGAAGATGCGGTTTTTTGTGGCC
AGGCATGGACCGAAGAAATCTTTCGCCAACTAGGTAATCAAGTGAAAATAACTTGGTTTGTCAAAGAGGGTGATTTTGTT
AAAGCCAATAGTCAATTATTTAGTCTTGAAGGAGCAGCGCGCACTTTATTAACGGGTGAACGTACAGCGCTTAATTTTAT
ACAAACATTGTCAGGTATTGCAACAACAGTGAAACAGTATACAGATTTAATCAAGGACACTGATTGTAAATTACTTGATA
CCCGTAAAACCTTACCCGGTTTACGTCATGCCTCAAAATATGCCGTGTTATGTGGCGGCGGTTTGAATCATCGTTTAGGT
CTGTATGACGCCTATTTAATTAAAGAAAACCACATTATGGCTTGTGGCGGCATTGAAGCGTCAGTCAAAATGGCTAAAAA
ACAACACCCGGAGCGATTAGTTGAAGTAGAAGTGGAGTCTATTGCGGAATTAAAAGAAGCATTAAATGCGGGCGCAGAGC
GTATTATGTTAGATAATTTCAGTATTGCAATGATGCTCGAAGCCGTGGCCCTTAATAGTGAAAACCCAAACTCAACGGCA
AAGTTAGAAGTTTCAGGTAATGTTAATAGCGACACTATCCTTCCCTACGCAAAAACGGGCGTGGATTATATTTCTGTGGG
CGCTTTAACCAAACATGTACGGGCCATCGATTTATCAATGCGTTTTATCGCTTAA

Upstream 100 bases:

>100_bases
GATTTATTTTTCTTATTTATAAGAGTTGTCACTGTAGAACATTGGTATTAACAATGCATTAAGGTAATATTTGTTTTTTT
ATTGTTAATGGAAATTCAGC

Downstream 100 bases:

>100_bases
TACCAAATTCTTTCATTTTTTTTGCATTTATGCAGGTTCAACCACATGATAACTAGATATAAAACACTAGCTTGGTCTTT
GCCATTGATTTGATTCATAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MVAQEIIRSVKIALDEDLNGLSPLEGDISANLIPEGRQAKAIVITREDAVFCGQAWTEEIFRQLGNQVKITWFVKEGDFV
KANSQLFSLEGAARTLLTGERTALNFIQTLSGIATTVKQYTDLIKDTDCKLLDTRKTLPGLRHASKYAVLCGGGLNHRLG
LYDAYLIKENHIMACGGIEASVKMAKKQHPERLVEVEVESIAELKEALNAGAERIMLDNFSIAMMLEAVALNSENPNSTA
KLEVSGNVNSDTILPYAKTGVDYISVGALTKHVRAIDLSMRFIA

Sequences:

>Translated_284_residues
MVAQEIIRSVKIALDEDLNGLSPLEGDISANLIPEGRQAKAIVITREDAVFCGQAWTEEIFRQLGNQVKITWFVKEGDFV
KANSQLFSLEGAARTLLTGERTALNFIQTLSGIATTVKQYTDLIKDTDCKLLDTRKTLPGLRHASKYAVLCGGGLNHRLG
LYDAYLIKENHIMACGGIEASVKMAKKQHPERLVEVEVESIAELKEALNAGAERIMLDNFSIAMMLEAVALNSENPNSTA
KLEVSGNVNSDTILPYAKTGVDYISVGALTKHVRAIDLSMRFIA
>Mature_284_residues
MVAQEIIRSVKIALDEDLNGLSPLEGDISANLIPEGRQAKAIVITREDAVFCGQAWTEEIFRQLGNQVKITWFVKEGDFV
KANSQLFSLEGAARTLLTGERTALNFIQTLSGIATTVKQYTDLIKDTDCKLLDTRKTLPGLRHASKYAVLCGGGLNHRLG
LYDAYLIKENHIMACGGIEASVKMAKKQHPERLVEVEVESIAELKEALNAGAERIMLDNFSIAMMLEAVALNSENPNSTA
KLEVSGNVNSDTILPYAKTGVDYISVGALTKHVRAIDLSMRFIA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=59.1397849462366, Blast_Score=305, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=33.7254901960784, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31066; Mature: 31066

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAQEIIRSVKIALDEDLNGLSPLEGDISANLIPEGRQAKAIVITREDAVFCGQAWTEEI
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECHHHHHHH
FRQLGNQVKITWFVKEGDFVKANSQLFSLEGAARTLLTGERTALNFIQTLSGIATTVKQY
HHHCCCEEEEEEEEECCCEEECCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TDLIKDTDCKLLDTRKTLPGLRHASKYAVLCGGGLNHRLGLYDAYLIKENHIMACGGIEA
HHHHCCCCCEEEECHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEECCCHH
SVKMAKKQHPERLVEVEVESIAELKEALNAGAERIMLDNFSIAMMLEAVALNSENPNSTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCEE
KLEVSGNVNSDTILPYAKTGVDYISVGALTKHVRAIDLSMRFIA
EEEECCCCCCCEECCCHHCCCCEEEHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure
MVAQEIIRSVKIALDEDLNGLSPLEGDISANLIPEGRQAKAIVITREDAVFCGQAWTEEI
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECHHHHHHH
FRQLGNQVKITWFVKEGDFVKANSQLFSLEGAARTLLTGERTALNFIQTLSGIATTVKQY
HHHCCCEEEEEEEEECCCEEECCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TDLIKDTDCKLLDTRKTLPGLRHASKYAVLCGGGLNHRLGLYDAYLIKENHIMACGGIEA
HHHHCCCCCEEEECHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEECCCHH
SVKMAKKQHPERLVEVEVESIAELKEALNAGAERIMLDNFSIAMMLEAVALNSENPNSTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCEE
KLEVSGNVNSDTILPYAKTGVDYISVGALTKHVRAIDLSMRFIA
EEEECCCCCCCEECCCHHCCCCEEEHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]