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The map label for this gene is purM [H]

Identifier: 119944827

GI number: 119944827

Start: 1342901

End: 1343947

Strand: Reverse

Name: purM [H]

Synonym: Ping_1069

Alternate gene names: 119944827

Gene position: 1343947-1342901 (Counterclockwise)

Preceding gene: 119944830

Following gene: 119944826

Centisome position: 29.48

GC content: 44.13

Gene sequence:

>1047_bases
ATGCAAGTGAGCAACGAAAAAACCTCTTTAAGCTATAAAGACGCGGGTGTTAATATTGACGCTGGTACTGCATTAGTTGA
ACGCATTAAAAGTGTAGCAAAACGTACTAAACGCCCGGAAGTAATGGGTGGATTGGGTGGTTTTGGCGCATTATGCCAAC
TGCCAACAGGGTATAAAGAGCCTTTATTAGTTGCAGGGACTGACGGTGTCGGTACAAAACTGCGTTTGGCAATTGACCTG
AAAAAACATGACACAGTCGGTATCGATTTAGTGGCAATGTGTGTAAACGATCTTATCGTTCAAGGTGCTGAACCGTTATT
TTTCCTGGATTATTATGCAACAGGAAAACTGGATATTGATGTTGCTGCTGCCGTTGTAACCGGTATCGGCGCGGGTTGCG
AGCTTGCAAACTGTTCGCTTATTGGTGGTGAAACTGCCGAAATGCCAGGTATGTATGAAGGTGACGATTACGATATCGCT
GGATTCTGTGTGGGTGTTGTTGAAAAAGCAGATGTTATTGACGGAACGAAAGTAGCCGCGGGTGATGCGCTTATTGCAGT
CGGTTCAAGTGGCCCGCATTCCAACGGTTACTCTCTAGTGCGTAAAATTTTAGAAGTATCAAAAGCCGATACCAGTGCCC
CCTTTGGTGACTCAACATTGGGTGAAACATTATTAACACCCACTAAAATTTACGTAAAATCAACGCTTGAATTAATCAAA
AACTGCCCTGTGCATGCAATTTCTCATATCACAGGCGGTGGTTTCTGGGAAAATATTCCACGCGCATTACCCGCCGGAAG
CAAAGCGGTTGTTGATGGTAAGAGCTGGGTATGGCCTGAGATTTTCAACTGGTTACAAGAGAATGGCAATGTCAAAACAG
AAGAAATGTACCGTACCTTTAACTGTGGTGTTGGTTTAGTGATTGTTGTGCCTAGCGCTGAAAAAGACAGAGCAGTTGAA
ATATTAACTGCTCAAGGTGAAAATGCCTGGGTACTTGGTCATATCGAAGACGCCGCAGCAGATGAAGCACAAGTCGAGAT
TAACTAA

Upstream 100 bases:

>100_bases
AAATAATTAGATCCTTGTCATATAAATGCTAAAATGCTGCTGTTTAAATCCATCAAATTCTATAAAAGCGAAATAGCTTT
TAAATTTAATTCTGCGAGGA

Downstream 100 bases:

>100_bases
ACAATTATGGCAACTGTAGCAACTAAAAAAATTGTCGTTCTGCTCTCTGGTAACGGTAGTAACCTGCAAAATATTATTGA
CAAGCTTCATAATACAACGC

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQVSNEKTSLSYKDAGVNIDAGTALVERIKSVAKRTKRPEVMGGLGGFGALCQLPTGYKEPLLVAGTDGVGTKLRLAIDL
KKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDIDVAAAVVTGIGAGCELANCSLIGGETAEMPGMYEGDDYDIA
GFCVGVVEKADVIDGTKVAAGDALIAVGSSGPHSNGYSLVRKILEVSKADTSAPFGDSTLGETLLTPTKIYVKSTLELIK
NCPVHAISHITGGGFWENIPRALPAGSKAVVDGKSWVWPEIFNWLQENGNVKTEEMYRTFNCGVGLVIVVPSAEKDRAVE
ILTAQGENAWVLGHIEDAAADEAQVEIN

Sequences:

>Translated_348_residues
MQVSNEKTSLSYKDAGVNIDAGTALVERIKSVAKRTKRPEVMGGLGGFGALCQLPTGYKEPLLVAGTDGVGTKLRLAIDL
KKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDIDVAAAVVTGIGAGCELANCSLIGGETAEMPGMYEGDDYDIA
GFCVGVVEKADVIDGTKVAAGDALIAVGSSGPHSNGYSLVRKILEVSKADTSAPFGDSTLGETLLTPTKIYVKSTLELIK
NCPVHAISHITGGGFWENIPRALPAGSKAVVDGKSWVWPEIFNWLQENGNVKTEEMYRTFNCGVGLVIVVPSAEKDRAVE
ILTAQGENAWVLGHIEDAAADEAQVEIN
>Mature_348_residues
MQVSNEKTSLSYKDAGVNIDAGTALVERIKSVAKRTKRPEVMGGLGGFGALCQLPTGYKEPLLVAGTDGVGTKLRLAIDL
KKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDIDVAAAVVTGIGAGCELANCSLIGGETAEMPGMYEGDDYDIA
GFCVGVVEKADVIDGTKVAAGDALIAVGSSGPHSNGYSLVRKILEVSKADTSAPFGDSTLGETLLTPTKIYVKSTLELIK
NCPVHAISHITGGGFWENIPRALPAGSKAVVDGKSWVWPEIFNWLQENGNVKTEEMYRTFNCGVGLVIVVPSAEKDRAVE
ILTAQGENAWVLGHIEDAAADEAQVEIN

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=48.5714285714286, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=48.5714285714286, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=48.5714285714286, Blast_Score=338, Evalue=4e-93,
Organism=Escherichia coli, GI1788845, Length=341, Percent_Identity=69.7947214076246, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=43.2664756446991, Blast_Score=257, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=345, Percent_Identity=47.8260869565217, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24582400, Length=291, Percent_Identity=43.6426116838488, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36675; Mature: 36675

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVSNEKTSLSYKDAGVNIDAGTALVERIKSVAKRTKRPEVMGGLGGFGALCQLPTGYKE
CCCCCCCCCEEECCCCCEECHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCC
PLLVAGTDGVGTKLRLAIDLKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDID
CEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
VAAAVVTGIGAGCELANCSLIGGETAEMPGMYEGDDYDIAGFCVGVVEKADVIDGTKVAA
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEC
GDALIAVGSSGPHSNGYSLVRKILEVSKADTSAPFGDSTLGETLLTPTKIYVKSTLELIK
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
NCPVHAISHITGGGFWENIPRALPAGSKAVVDGKSWVWPEIFNWLQENGNVKTEEMYRTF
CCCHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHH
NCGVGLVIVVPSAEKDRAVEILTAQGENAWVLGHIEDAAADEAQVEIN
CCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEEEC
>Mature Secondary Structure
MQVSNEKTSLSYKDAGVNIDAGTALVERIKSVAKRTKRPEVMGGLGGFGALCQLPTGYKE
CCCCCCCCCEEECCCCCEECHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCC
PLLVAGTDGVGTKLRLAIDLKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDID
CEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
VAAAVVTGIGAGCELANCSLIGGETAEMPGMYEGDDYDIAGFCVGVVEKADVIDGTKVAA
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEC
GDALIAVGSSGPHSNGYSLVRKILEVSKADTSAPFGDSTLGETLLTPTKIYVKSTLELIK
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
NCPVHAISHITGGGFWENIPRALPAGSKAVVDGKSWVWPEIFNWLQENGNVKTEEMYRTF
CCCHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCEEHHHHHHHH
NCGVGLVIVVPSAEKDRAVEILTAQGENAWVLGHIEDAAADEAQVEIN
CCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA