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The map label for this gene is menB [H]

Identifier: 119944134

GI number: 119944134

Start: 452767

End: 453609

Strand: Reverse

Name: menB [H]

Synonym: Ping_0350

Alternate gene names: 119944134

Gene position: 453609-452767 (Counterclockwise)

Preceding gene: 119944135

Following gene: 119944133

Centisome position: 9.95

GC content: 46.98

Gene sequence:

>843_bases
ATGCCTGAAAAAGAGGGTTATGCACCCATTGCATGGAAAAAAAGCGCGTTAAACTTCACTGACATTCTCTACCACAAAGC
CGATGGAATCGCCAAAATAACGATTAACCGTCCGCATATTCGTAACGCTTTTCGTCCAAAAACAGTGAATGAAATGATGC
AGGCACTGCAGGATGCGCGTTATGATGGTGATATTGGTGTCATTATTCTTACCGGTCAAGGTCCCTTATCTTTTTGTTCT
GGAGGGGATCAGAGCGTCCGTGGTGACTCCGGTTATAAAGATGAGAGCGGCGGTCATCATCTTAACGTTCTGGATTTTCA
ACGCCAGATTCGCACTTGCCCCAAACCTGTCATTGCTATGGTAGCGGGTTACGCAGTGGGTGGCGGTCATGTCTTACATA
TGATGTGCGATTTAACCATCGCGGCTGACAACGCACAGTTTGGTCAAACTGGCCCTAAAGTAGGCTCCTTTGATGGTGGC
TGGGGGGCCAGTTATATGGCGCGCATCGTTGGTCAGAAAAAAGCACGCGAAATTTGGTTTTTATGCCGCATGTATGATGC
GCAAGAAGCGCTGGATATGGGGATGGTCAATACCGTTGTTCCGCTTGTTTATTTAGAAAACGAAACCGTAAAATGGTGCA
GAGAGATCCTGCAAAACAGCCCGATGGCATTGCGCTGCTTGAAAGCTGCATTAAATGCGGATTGTGACGGACAGGCCGGA
TTACAAGAGCTGGCCGGTAATGCCACTATGCTTTTTTATATGAGCGAAGAGGGGCAGGAGGGACGTAATGCTTTTAATGA
AAAGCGTAAACCCGATTTTTCAAAATTTGGCCGAAACCCATAA

Upstream 100 bases:

>100_bases
GGCAGGTCATAATATTCACCAACAGAGTCCTGTGCAATATGCGCGCTTTATTAAGCAGCATTTTAGTCAATAATTTTTAG
ATAATAATTAAGAGAAAAAT

Downstream 100 bases:

>100_bases
TTATTGCTGAGCACTCTTCTCTTATATTATCGTGCCCCTTGAGCGGGTAAACATAGGCAAGTCCTTTGGGTATAACAGAA
AATTTTATAAATTTGCTCTA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPEKEGYAPIAWKKSALNFTDILYHKADGIAKITINRPHIRNAFRPKTVNEMMQALQDARYDGDIGVIILTGQGPLSFCS
GGDQSVRGDSGYKDESGGHHLNVLDFQRQIRTCPKPVIAMVAGYAVGGGHVLHMMCDLTIAADNAQFGQTGPKVGSFDGG
WGASYMARIVGQKKAREIWFLCRMYDAQEALDMGMVNTVVPLVYLENETVKWCREILQNSPMALRCLKAALNADCDGQAG
LQELAGNATMLFYMSEEGQEGRNAFNEKRKPDFSKFGRNP

Sequences:

>Translated_280_residues
MPEKEGYAPIAWKKSALNFTDILYHKADGIAKITINRPHIRNAFRPKTVNEMMQALQDARYDGDIGVIILTGQGPLSFCS
GGDQSVRGDSGYKDESGGHHLNVLDFQRQIRTCPKPVIAMVAGYAVGGGHVLHMMCDLTIAADNAQFGQTGPKVGSFDGG
WGASYMARIVGQKKAREIWFLCRMYDAQEALDMGMVNTVVPLVYLENETVKWCREILQNSPMALRCLKAALNADCDGQAG
LQELAGNATMLFYMSEEGQEGRNAFNEKRKPDFSKFGRNP
>Mature_279_residues
PEKEGYAPIAWKKSALNFTDILYHKADGIAKITINRPHIRNAFRPKTVNEMMQALQDARYDGDIGVIILTGQGPLSFCSG
GDQSVRGDSGYKDESGGHHLNVLDFQRQIRTCPKPVIAMVAGYAVGGGHVLHMMCDLTIAADNAQFGQTGPKVGSFDGGW
GASYMARIVGQKKAREIWFLCRMYDAQEALDMGMVNTVVPLVYLENETVKWCREILQNSPMALRCLKAALNADCDGQAGL
QELAGNATMLFYMSEEGQEGRNAFNEKRKPDFSKFGRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=271, Percent_Identity=32.8413284132841, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=32.9365079365079, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=28.5067873303167, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=28.5067873303167, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=28.5067873303167, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI116235487, Length=221, Percent_Identity=27.6018099547511, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4757968, Length=244, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI49355787, Length=244, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788597, Length=276, Percent_Identity=82.9710144927536, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=28.7937743190661, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082183, Length=250, Percent_Identity=30.4, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI221142681, Length=249, Percent_Identity=30.1204819277108, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=28.8389513108614, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788682, Length=230, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=247, Percent_Identity=31.9838056680162, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=32.6693227091633, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=217, Percent_Identity=29.4930875576037, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=26.9767441860465, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=208, Percent_Identity=27.4038461538462, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=169, Percent_Identity=29.585798816568, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=26.8939393939394, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=216, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=36.1788617886179, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=36.1788617886179, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653139, Length=277, Percent_Identity=29.2418772563177, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21357171, Length=198, Percent_Identity=30.8080808080808, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654903, Length=200, Percent_Identity=28, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922422, Length=206, Percent_Identity=28.1553398058252, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650670, Length=185, Percent_Identity=30.2702702702703, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30863; Mature: 30731

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00018 EF_HAND_1 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKEGYAPIAWKKSALNFTDILYHKADGIAKITINRPHIRNAFRPKTVNEMMQALQDAR
CCCCCCCCCCEECCCCCCHHHHHHCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHCC
YDGDIGVIILTGQGPLSFCSGGDQSVRGDSGYKDESGGHHLNVLDFQRQIRTCPKPVIAM
CCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCHHHHHH
VAGYAVGGGHVLHMMCDLTIAADNAQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWF
HHHHCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LCRMYDAQEALDMGMVNTVVPLVYLENETVKWCREILQNSPMALRCLKAALNADCDGQAG
HHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHH
LQELAGNATMLFYMSEEGQEGRNAFNEKRKPDFSKFGRNP
HHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
PEKEGYAPIAWKKSALNFTDILYHKADGIAKITINRPHIRNAFRPKTVNEMMQALQDAR
CCCCCCCCCEECCCCCCHHHHHHCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHCC
YDGDIGVIILTGQGPLSFCSGGDQSVRGDSGYKDESGGHHLNVLDFQRQIRTCPKPVIAM
CCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCHHHHHH
VAGYAVGGGHVLHMMCDLTIAADNAQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWF
HHHHCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LCRMYDAQEALDMGMVNTVVPLVYLENETVKWCREILQNSPMALRCLKAALNADCDGQAG
HHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHH
LQELAGNATMLFYMSEEGQEGRNAFNEKRKPDFSKFGRNP
HHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]