Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 119944133

GI number: 119944133

Start: 449913

End: 451559

Strand: Reverse

Name: ilvG [H]

Synonym: Ping_0348

Alternate gene names: 119944133

Gene position: 451559-449913 (Counterclockwise)

Preceding gene: 119944134

Following gene: 119944132

Centisome position: 9.9

GC content: 46.39

Gene sequence:

>1647_bases
ATGAATGGTGCCCACTCTGTCGTTCAGGCATTAAAGCAGCAAAACGTAACGCAAGTTTTTGGTTATCCTGGCGGGGCAAT
TATGCCCTTGTATGATGCACTCTATGATGGCGGTGTGGAACATCTTCTCTGCCGTCATGAACAAGGTGCGGCAATGGCCG
CTATCGGTTATGCACGCGCAACCGGGAAAACTGGAGTCTGTATAGCCACTTCAGGCCCAGGCGCAACCAACCTGATAACA
GGACTTGCAGATGCATTATTAGATTCAATTCCCATTGTCGCTATCACCGGTCAAGTGGCCAGCCATTTAATTGGCACCGA
TGCTTTTCAGGAAGTTGATGTACTGGGCCTTTCTTTAGCCTGTACCAAACATAGTTTTATGGTACCAAGCGCAGAACAGT
TAGGGCCGATAATTGAGCAGGCGTTTCAAATTGCTCAGTCGGGCCGCCCCGGTCCCGTCCTAATAGATATTCCCAAGGAT
ATTCAACTTGCAGATGCGGTTATCCATCACTTGACACAGACCGAAAGCGACTCAAAACCCTTAGATAATTCATTGCTGAG
AAAGGCAAGGTCAATGATTCGAGCGGCCGCTAAACCCCTTGTCTATGTAGGGGGTGGTGTCGGTATGGCCGGCGCTGTCA
CAGAATTACGCAGTTTCCTTAAAAAATCTAAAATTCCCAGTGTCTGTACATTAAAAGGCATTGGCTGTATTCCCTATAAC
TCCGATTATTTTCTCGGCATGGTGGGAATGCACGGCAGTAAGGCGGCCAATATAGCCATTCAAGAGTGCGACCTGCTGAT
TGCTGTTGGCGCGCGATTTGACGATCGGGTTACCGGAAAACTAGAAGAATTTGCTCCCCATGCAAAAGTTATCCACCTTG
ATGTCGATGCCGCCGAAATAGATAAGTTACGGGTGGTTGAGCTGGCCATGAGTGATGATTTGAAATTAATTTTACCGTCA
ATAGAAACCACCTCCAGCATACTCAACTGGCGAACTCACGTCGCCAAAATGAAAGTGGATTTTGCAAATCGTTATGACCA
TCCCGGAGGAGCTATTTTTGCTCCCGCCCTGCTTAGACAAATCGCAAAAATAATGCCTAGAGACACGGTTATCTGTAGTG
ACGTAGGGCAGCATCAGATGTGGGTTGCACAGCATATGTTTGTCGATCGTCCTGAAAACCATATTTCCAGTTCAGGTTTG
GGGACTATGGGTTTTGGAATTCCAGCAGCTGTTGGCGCACAAATGGCGAGACCTGATGATACCGTTATTGCGGTTTCAGG
TGATGGTTCATTTATGATGAATGTACAGGAACTTGGGACTATCAAACGTGGCAAACTACCAATTAAAATCGTTCTGATTG
ATAATCAGCGCTTAGGGATGGTACGTCAATGGCAGCAGTTGTTTTTTGATGGCCGCTATAGTGAAACGATTTTAAGCGAT
AATCCAGATTTTGTGACTCTGGCAAGTGCCTTTGATATTCCCGGCGAAACTATTGTGGCAAAATCGCAGATCCACGATGC
ATTGACCAGACTGCTTAACAGTAAAGGTGCCTATTTGTTACATGTGTCTATTTCAGAAACAGAGAATGTCTGGCCATTGG
TGCCACCGGGCGCTGCAAATCACAAAATGATGGAGAGTTTAGAATGA

Upstream 100 bases:

>100_bases
TTGTTATAAAGACACACTCTAAAATGTTACTCATTACTTGTTTTGATTTTTTATGATTAAAACAAAAACGATAAGTATTC
ACTAAATTCAGGAATAAACT

Downstream 100 bases:

>100_bases
AATACTTGATGATAATTCAAGGTGAGAATAGCCCTGAATTATTGGAACGACTGTTACGTGTTATTCGCCATCGCGGTTTC
TTTGTGCAAAAAATAAATGC

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNGAHSVVQALKQQNVTQVFGYPGGAIMPLYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVASHLIGTDAFQEVDVLGLSLACTKHSFMVPSAEQLGPIIEQAFQIAQSGRPGPVLIDIPKD
IQLADAVIHHLTQTESDSKPLDNSLLRKARSMIRAAAKPLVYVGGGVGMAGAVTELRSFLKKSKIPSVCTLKGIGCIPYN
SDYFLGMVGMHGSKAANIAIQECDLLIAVGARFDDRVTGKLEEFAPHAKVIHLDVDAAEIDKLRVVELAMSDDLKLILPS
IETTSSILNWRTHVAKMKVDFANRYDHPGGAIFAPALLRQIAKIMPRDTVICSDVGQHQMWVAQHMFVDRPENHISSSGL
GTMGFGIPAAVGAQMARPDDTVIAVSGDGSFMMNVQELGTIKRGKLPIKIVLIDNQRLGMVRQWQQLFFDGRYSETILSD
NPDFVTLASAFDIPGETIVAKSQIHDALTRLLNSKGAYLLHVSISETENVWPLVPPGAANHKMMESLE

Sequences:

>Translated_548_residues
MNGAHSVVQALKQQNVTQVFGYPGGAIMPLYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVASHLIGTDAFQEVDVLGLSLACTKHSFMVPSAEQLGPIIEQAFQIAQSGRPGPVLIDIPKD
IQLADAVIHHLTQTESDSKPLDNSLLRKARSMIRAAAKPLVYVGGGVGMAGAVTELRSFLKKSKIPSVCTLKGIGCIPYN
SDYFLGMVGMHGSKAANIAIQECDLLIAVGARFDDRVTGKLEEFAPHAKVIHLDVDAAEIDKLRVVELAMSDDLKLILPS
IETTSSILNWRTHVAKMKVDFANRYDHPGGAIFAPALLRQIAKIMPRDTVICSDVGQHQMWVAQHMFVDRPENHISSSGL
GTMGFGIPAAVGAQMARPDDTVIAVSGDGSFMMNVQELGTIKRGKLPIKIVLIDNQRLGMVRQWQQLFFDGRYSETILSD
NPDFVTLASAFDIPGETIVAKSQIHDALTRLLNSKGAYLLHVSISETENVWPLVPPGAANHKMMESLE
>Mature_548_residues
MNGAHSVVQALKQQNVTQVFGYPGGAIMPLYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVASHLIGTDAFQEVDVLGLSLACTKHSFMVPSAEQLGPIIEQAFQIAQSGRPGPVLIDIPKD
IQLADAVIHHLTQTESDSKPLDNSLLRKARSMIRAAAKPLVYVGGGVGMAGAVTELRSFLKKSKIPSVCTLKGIGCIPYN
SDYFLGMVGMHGSKAANIAIQECDLLIAVGARFDDRVTGKLEEFAPHAKVIHLDVDAAEIDKLRVVELAMSDDLKLILPS
IETTSSILNWRTHVAKMKVDFANRYDHPGGAIFAPALLRQIAKIMPRDTVICSDVGQHQMWVAQHMFVDRPENHISSSGL
GTMGFGIPAAVGAQMARPDDTVIAVSGDGSFMMNVQELGTIKRGKLPIKIVLIDNQRLGMVRQWQQLFFDGRYSETILSD
NPDFVTLASAFDIPGETIVAKSQIHDALTRLLNSKGAYLLHVSISETENVWPLVPPGAANHKMMESLE

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=481, Percent_Identity=27.2349272349272, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI21361361, Length=515, Percent_Identity=24.2718446601942, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1790104, Length=553, Percent_Identity=43.0379746835443, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI87081685, Length=568, Percent_Identity=40.669014084507, Blast_Score=434, Evalue=1e-122,
Organism=Escherichia coli, GI1786717, Length=496, Percent_Identity=31.4516129032258, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1787096, Length=546, Percent_Identity=28.021978021978, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1788716, Length=547, Percent_Identity=24.6800731261426, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=28.9256198347107, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=28.9256198347107, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17542570, Length=592, Percent_Identity=22.1283783783784, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323755, Length=571, Percent_Identity=40.1050788091068, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320588, Length=569, Percent_Identity=21.6168717047452, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320816, Length=472, Percent_Identity=21.3983050847458, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=479, Percent_Identity=22.5469728601253, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=474, Percent_Identity=23.2067510548523, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922626, Length=481, Percent_Identity=27.6507276507277, Blast_Score=168, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 58809; Mature: 58809

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAHSVVQALKQQNVTQVFGYPGGAIMPLYDALYDGGVEHLLCRHEQGAAMAAIGYARA
CCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEHHHHC
TGKTGVCIATSGPGATNLITGLADALLDSIPIVAITGQVASHLIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCHHHHHHHHHEEEEE
CTKHSFMVPSAEQLGPIIEQAFQIAQSGRPGPVLIDIPKDIQLADAVIHHLTQTESDSKP
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
LDNSLLRKARSMIRAAAKPLVYVGGGVGMAGAVTELRSFLKKSKIPSVCTLKGIGCIPYN
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCEECCCC
SDYFLGMVGMHGSKAANIAIQECDLLIAVGARFDDRVTGKLEEFAPHAKVIHLDVDAAEI
CCCEEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCHHHH
DKLRVVELAMSDDLKLILPSIETTSSILNWRTHVAKMKVDFANRYDHPGGAIFAPALLRQ
CCEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHH
IAKIMPRDTVICSDVGQHQMWVAQHMFVDRPENHISSSGLGTMGFGIPAAVGAQMARPDD
HHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
TVIAVSGDGSFMMNVQELGTIKRGKLPIKIVLIDNQRLGMVRQWQQLFFDGRYSETILSD
CEEEEECCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEECC
NPDFVTLASAFDIPGETIVAKSQIHDALTRLLNSKGAYLLHVSISETENVWPLVPPGAAN
CCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
HKMMESLE
HHHHHHCC
>Mature Secondary Structure
MNGAHSVVQALKQQNVTQVFGYPGGAIMPLYDALYDGGVEHLLCRHEQGAAMAAIGYARA
CCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEHHHHC
TGKTGVCIATSGPGATNLITGLADALLDSIPIVAITGQVASHLIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCHHHHHHHHHEEEEE
CTKHSFMVPSAEQLGPIIEQAFQIAQSGRPGPVLIDIPKDIQLADAVIHHLTQTESDSKP
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
LDNSLLRKARSMIRAAAKPLVYVGGGVGMAGAVTELRSFLKKSKIPSVCTLKGIGCIPYN
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCEECCCC
SDYFLGMVGMHGSKAANIAIQECDLLIAVGARFDDRVTGKLEEFAPHAKVIHLDVDAAEI
CCCEEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCHHHH
DKLRVVELAMSDDLKLILPSIETTSSILNWRTHVAKMKVDFANRYDHPGGAIFAPALLRQ
CCEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHH
IAKIMPRDTVICSDVGQHQMWVAQHMFVDRPENHISSSGLGTMGFGIPAAVGAQMARPDD
HHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
TVIAVSGDGSFMMNVQELGTIKRGKLPIKIVLIDNQRLGMVRQWQQLFFDGRYSETILSD
CEEEEECCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEECC
NPDFVTLASAFDIPGETIVAKSQIHDALTRLLNSKGAYLLHVSISETENVWPLVPPGAAN
CCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
HKMMESLE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]