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The map label for this gene is lexA

Identifier: 119943901

GI number: 119943901

Start: 140042

End: 140671

Strand: Direct

Name: lexA

Synonym: Ping_0108

Alternate gene names: 119943901

Gene position: 140042-140671 (Clockwise)

Preceding gene: 119943900

Following gene: 119943902

Centisome position: 3.07

GC content: 41.75

Gene sequence:

>630_bases
ATGAAAGAGCTAACCAAGCGTCAAAATGAAGTATTGGATGTGATCAAAGATCAAATATTAAAGACGGGAATGCCTCCTAC
ACGAGTTGAATTAGCTAAGATCCTTGGTTTTCGAAGCGCTAATGCAGCAGAAGAGCACCTTAAAGCTTTAGCGCGTAAAG
GTGCGATTGAAATTTTAGCAGGCACATCTCGTGGAATCCGTCTTTTGGGTGAGCATCAACATAATGAAAAAGCGCACCAG
GACGGATTGCCTCTTATTGGTCAAGTCGCTGCAGGTGAACCGATTTTAGCTCAGCAGCATATTGAAACCTATTATGATGT
TGATCCTGCTTTATTTCACCCTAGTGCTGATTTTTTACTGCGAGTGCAGGGTGAAAGCATGAAAGATATCGGTATTATGG
ATGGTGATCTGCTGGCTGTACATAAAACCCAAGATATCAAAAACGGGCAAGTGGTCATCGCCCGTGTTGAAGATGATGTA
ACAGTCAAACGTTTTTATCGAGAAGGCCGCCAGGTGATATTAAAAGCAGAAAACAATGATTTTGGTCCGATTAAAATAGA
CCTTGCATATCAATCTTTTGATATCGAAGGGATAGCCGTTGGTGTCATTCGAACAGCAGATTGGATGTAA

Upstream 100 bases:

>100_bases
TGATGGATTGACTCAAAAATATTGTTTGGAACTAGATTAACTCCATGTATGAATATACACTGTTCATGTTTACAGTTAAA
TTTAGCGTGGAGATTAAATA

Downstream 100 bases:

>100_bases
TGTCAGCTGTTTTATTTACAGTCTGGCTGTAGTATGAATTGAGCACATTTACCCTCTTTAGATAAGATGATTTTTAATTT
AACGGGTTATTGAAATGAAA

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKELTKRQNEVLDVIKDQILKTGMPPTRVELAKILGFRSANAAEEHLKALARKGAIEILAGTSRGIRLLGEHQHNEKAHQ
DGLPLIGQVAAGEPILAQQHIETYYDVDPALFHPSADFLLRVQGESMKDIGIMDGDLLAVHKTQDIKNGQVVIARVEDDV
TVKRFYREGRQVILKAENNDFGPIKIDLAYQSFDIEGIAVGVIRTADWM

Sequences:

>Translated_209_residues
MKELTKRQNEVLDVIKDQILKTGMPPTRVELAKILGFRSANAAEEHLKALARKGAIEILAGTSRGIRLLGEHQHNEKAHQ
DGLPLIGQVAAGEPILAQQHIETYYDVDPALFHPSADFLLRVQGESMKDIGIMDGDLLAVHKTQDIKNGQVVIARVEDDV
TVKRFYREGRQVILKAENNDFGPIKIDLAYQSFDIEGIAVGVIRTADWM
>Mature_209_residues
MKELTKRQNEVLDVIKDQILKTGMPPTRVELAKILGFRSANAAEEHLKALARKGAIEILAGTSRGIRLLGEHQHNEKAHQ
DGLPLIGQVAAGEPILAQQHIETYYDVDPALFHPSADFLLRVQGESMKDIGIMDGDLLAVHKTQDIKNGQVVIARVEDDV
TVKRFYREGRQVILKAENNDFGPIKIDLAYQSFDIEGIAVGVIRTADWM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=209, Percent_Identity=67.9425837320574, Blast_Score=291, Evalue=2e-80,
Organism=Escherichia coli, GI1787431, Length=125, Percent_Identity=34.4, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_PSYIN (A1SR67)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941581.1
- ProteinModelPortal:   A1SR67
- SMR:   A1SR67
- STRING:   A1SR67
- MEROPS:   S24.001
- GeneID:   4626177
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0108
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- PhylomeDB:   A1SR67
- BioCyc:   PING357804:PING_0108-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23241; Mature: 23241

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 163-163

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELTKRQNEVLDVIKDQILKTGMPPTRVELAKILGFRSANAAEEHLKALARKGAIEILA
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GTSRGIRLLGEHQHNEKAHQDGLPLIGQVAAGEPILAQQHIETYYDVDPALFHPSADFLL
CCCCCEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHCCCCCCEEE
RVQGESMKDIGIMDGDLLAVHKTQDIKNGQVVIARVEDDVTVKRFYREGRQVILKAENND
EECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCC
FGPIKIDLAYQSFDIEGIAVGVIRTADWM
CCCEEEEEEEEEECCCEEEEEEEECCCCC
>Mature Secondary Structure
MKELTKRQNEVLDVIKDQILKTGMPPTRVELAKILGFRSANAAEEHLKALARKGAIEILA
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GTSRGIRLLGEHQHNEKAHQDGLPLIGQVAAGEPILAQQHIETYYDVDPALFHPSADFLL
CCCCCEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHCCCCCCEEE
RVQGESMKDIGIMDGDLLAVHKTQDIKNGQVVIARVEDDVTVKRFYREGRQVILKAENND
EECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCC
FGPIKIDLAYQSFDIEGIAVGVIRTADWM
CCCEEEEEEEEEECCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA