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The map label for this gene is menA [H]

Identifier: 119899902

GI number: 119899902

Start: 3965391

End: 3966347

Strand: Direct

Name: menA [H]

Synonym: azo3613

Alternate gene names: 119899902

Gene position: 3965391-3966347 (Clockwise)

Preceding gene: 119899901

Following gene: 119899904

Centisome position: 90.62

GC content: 72.2

Gene sequence:

>957_bases
GTGCGTACTCCCGCCGAACCCCGCGCCGACAGCGGCCAGCCGCGCGCGCTCGTCCTCCTCGCCGCTACCCGCCCGGCCTT
TCTGTCGATCACGCTGGTCGGCTGCCTGATCGGGCTGGCGAGCGCCGCCGGCAGCGGCGTGGCGGTCGACGCCTGGAGCG
CGGCGCTGACGGTCCTGGCCGCGCTGCTTACGCACGCCGGCGCCAATGTCGTCAACGACTATCACGACGCGCGCAGCGGT
GCCGACGAGGCCAACCGGAACCGGCTTTTTCCGTACACCGGCGGCAGCCGCTTCATCCAGAACGGCGTGCTCGGCGTGCG
TGAAACCGGCCGGTTCGGCCACGCCCTGCTCGCGCTCGTCGTGCCTGCCGGGCTGTGGCTGGCGTGGCATGCGGGGGCGG
GTCTGCTGGCGATCGGCGCCGCGGGTCTGCTGCTCGGCTGGGCGTATTCCGCGCCGCCGCTGGCCCTGATGAGTCGCGGG
CTGGGCGAACTCGCGATCGCCGCGGCGTGGCTGCTGGTGGTGGTGGGGGCGGATTATGTGCAGCGGCGCGCGTTCAGCCC
GCTGCCCGCAATGGCCGGGCTGTCATACGCGCTGCTGGTCGCCAGCCTGCTGTTCATCAACCAGTTTCCCGACCACGACG
GCGACGCTGCCGCGGGCAAGCGCACGCTGGTCGTCCGGCTGGGGCCCGACACCGCCAAATGGGCCTACCTGCTGATCGCC
ATCGTGGCCTACGGCTGGCTGGTGGCAATGGTGGCGGTGGAACGGCTGCCGCAGAAAGCGGGGGCTGCGGCGCTGACGCT
GGTGTTCTCGTTTTCGGCCGCACGGGAACTGCTGGCCCATGCCCGGCAGCCGGACGAACTGGAAGGGGCGATCAAACGGA
CCATCCTCGCGGCCAACCTGCACGGTCTGGCGCTTGCCGCGGCGCTGGCCTTTGCGGCCTGGCCCCGCCGCGGCTGA

Upstream 100 bases:

>100_bases
TGGCGATGCTGTCGGACTTCATCGACAAGAAGATCTCGCTGCACCCCGAGGCGAGCTACACCCAGGAACAGTTCGACATC
GTGCTGCTGTAAGGCGTCTT

Downstream 100 bases:

>100_bases
CCTGGAGCTGCCGCCTAGTTGCTGCTGCCGCCGCAGGCGTGAAGGCTGGTGTCGCGCCCGCACTGGTGGAAGTTGCCGAG
CGGACGATAGAAGGTGTACT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRTPAEPRADSGQPRALVLLAATRPAFLSITLVGCLIGLASAAGSGVAVDAWSAALTVLAALLTHAGANVVNDYHDARSG
ADEANRNRLFPYTGGSRFIQNGVLGVRETGRFGHALLALVVPAGLWLAWHAGAGLLAIGAAGLLLGWAYSAPPLALMSRG
LGELAIAAAWLLVVVGADYVQRRAFSPLPAMAGLSYALLVASLLFINQFPDHDGDAAAGKRTLVVRLGPDTAKWAYLLIA
IVAYGWLVAMVAVERLPQKAGAAALTLVFSFSAARELLAHARQPDELEGAIKRTILAANLHGLALAAALAFAAWPRRG

Sequences:

>Translated_318_residues
MRTPAEPRADSGQPRALVLLAATRPAFLSITLVGCLIGLASAAGSGVAVDAWSAALTVLAALLTHAGANVVNDYHDARSG
ADEANRNRLFPYTGGSRFIQNGVLGVRETGRFGHALLALVVPAGLWLAWHAGAGLLAIGAAGLLLGWAYSAPPLALMSRG
LGELAIAAAWLLVVVGADYVQRRAFSPLPAMAGLSYALLVASLLFINQFPDHDGDAAAGKRTLVVRLGPDTAKWAYLLIA
IVAYGWLVAMVAVERLPQKAGAAALTLVFSFSAARELLAHARQPDELEGAIKRTILAANLHGLALAAALAFAAWPRRG
>Mature_318_residues
MRTPAEPRADSGQPRALVLLAATRPAFLSITLVGCLIGLASAAGSGVAVDAWSAALTVLAALLTHAGANVVNDYHDARSG
ADEANRNRLFPYTGGSRFIQNGVLGVRETGRFGHALLALVVPAGLWLAWHAGAGLLAIGAAGLLLGWAYSAPPLALMSRG
LGELAIAAAWLLVVVGADYVQRRAFSPLPAMAGLSYALLVASLLFINQFPDHDGDAAAGKRTLVVRLGPDTAKWAYLLIA
IVAYGWLVAMVAVERLPQKAGAAALTLVFSFSAARELLAHARQPDELEGAIKRTILAANLHGLALAAALAFAAWPRRG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=222, Percent_Identity=30.1801801801802, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33013; Mature: 33013

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPAEPRADSGQPRALVLLAATRPAFLSITLVGCLIGLASAAGSGVAVDAWSAALTVLA
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALLTHAGANVVNDYHDARSGADEANRNRLFPYTGGSRFIQNGVLGVRETGRFGHALLALV
HHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
VPAGLWLAWHAGAGLLAIGAAGLLLGWAYSAPPLALMSRGLGELAIAAAWLLVVVGADYV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QRRAFSPLPAMAGLSYALLVASLLFINQFPDHDGDAAAGKRTLVVRLGPDTAKWAYLLIA
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
IVAYGWLVAMVAVERLPQKAGAAALTLVFSFSAARELLAHARQPDELEGAIKRTILAANL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HGLALAAALAFAAWPRRG
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTPAEPRADSGQPRALVLLAATRPAFLSITLVGCLIGLASAAGSGVAVDAWSAALTVLA
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALLTHAGANVVNDYHDARSGADEANRNRLFPYTGGSRFIQNGVLGVRETGRFGHALLALV
HHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
VPAGLWLAWHAGAGLLAIGAAGLLLGWAYSAPPLALMSRGLGELAIAAAWLLVVVGADYV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QRRAFSPLPAMAGLSYALLVASLLFINQFPDHDGDAAAGKRTLVVRLGPDTAKWAYLLIA
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
IVAYGWLVAMVAVERLPQKAGAAALTLVFSFSAARELLAHARQPDELEGAIKRTILAANL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HGLALAAALAFAAWPRRG
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]