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The map label for this gene is fba [H]

Identifier: 119899133

GI number: 119899133

Start: 3121901

End: 3122965

Strand: Direct

Name: fba [H]

Synonym: azo2843

Alternate gene names: 119899133

Gene position: 3121901-3122965 (Clockwise)

Preceding gene: 119899132

Following gene: 119899136

Centisome position: 71.34

GC content: 65.63

Gene sequence:

>1065_bases
ATGCCCCTCGTTTCCATGCGCCAGCTGCTCGACCACGCCGCCGAGAACAGCTACGGTCTGCCGGCGTTCAACGTGAACAA
CTTGGAACAGGTCCAGGCCATCATGGAAGCCGCGGCCGAAACCGACAGCCCCGTGATCATGCAGGCCTCTGCCGGGGCGC
GTAAGTACGCGGGCGAAGCCTTCCTGCGCCACCTCATCGACGCCGCGGTCGAAGCCTATCCGCACATCCCCGTGGTGATG
CACCAGGACCACGGCCAGAGCCCCGCGGTCTGCATGGCCGCCATCCGCTCGGGCTTCTCCAGCGTGATGATGGACGGCTC
GCTGATGGAAGACGGCAAGACGCCCTCCTCCTACGAATACAACGTCGCCGTCACCCGCGAAGTGGTGAAGTTCTCGCACG
CCATCGGCGTCACCGTGGAAGCCGAACTCGGCTGCCTCGGCTCGCTGGAAACCGGCATGGCCGGCGAGGAAGACGGCATT
GGCGCCGAAGGCAAGCTCGACCACAGCGCGCTGCTGACCGATCCCGACCAGGCCGCCGACTTCGTCAAGCAGACCGACTG
CGACGCGCTTGCGATCGCCATCGGCACCAGCCACGGCGCCTACAAGTTCACCCGCAAGCCCACCGGCGACATCCTCGCGA
TCGACCGCATCAAGGCCATCCACGCCCGCCTGCCGAACACCCACCTGGTCATGCACGGCTCCAGCTCGGTGCCGCAGGAC
CTGCTGGAAATCATCCGCCAGTACGGCGGCGACATGAAGGAAACCTACGGCGTGCCGGTCGAGGAAATCGTCGAGGGCAT
CAAGTACGGCGTGCGCAAGATCAACATCGACACCGACATCCGCCTGGCGATGACCGGCGCGATCCGCAAGTTCTTCGTCG
AGAACCCGTCCAAGTTCGACCCGCGCGAATTCCTCAAGCCCGCGCGCGAAGCTGCGAAGCTGATCTGCAAGGCCCGCTTC
GAAGCCTTCGGCAGCGCCGGCCAGGCGAGCAAGATCAAGCCGGTGGCGCTCGACAAGATCGCCGCGCGCTACAAGGCCGG
CGAACTGACCCAGGTCGTGCGCTGA

Upstream 100 bases:

>100_bases
GCAAACGCGCTTACCGCCCCGCACCGCGCCCGGATAAAATGCCGGTTTCCGTATCGACCAACACAGGCGGCGGCCTGCGC
CGCCCACCCGGAGAATTACC

Downstream 100 bases:

>100_bases
ACTCGCACCCTGTCCGCAGCAACGAAAAACGCGCCCGAGGGCGCGTTTTTCGTTTCCTGAGGCCGCTATTTCTTCGGCCG
CACGGCGTCGGCAGTGCCGA

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENSYGLPAFNVNNLEQVQAIMEAAAETDSPVIMQASAGARKYAGEAFLRHLIDAAVEAYPHIPVVM
HQDHGQSPAVCMAAIRSGFSSVMMDGSLMEDGKTPSSYEYNVAVTREVVKFSHAIGVTVEAELGCLGSLETGMAGEEDGI
GAEGKLDHSALLTDPDQAADFVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHARLPNTHLVMHGSSSVPQD
LLEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFFVENPSKFDPREFLKPAREAAKLICKARF
EAFGSAGQASKIKPVALDKIAARYKAGELTQVVR

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENSYGLPAFNVNNLEQVQAIMEAAAETDSPVIMQASAGARKYAGEAFLRHLIDAAVEAYPHIPVVM
HQDHGQSPAVCMAAIRSGFSSVMMDGSLMEDGKTPSSYEYNVAVTREVVKFSHAIGVTVEAELGCLGSLETGMAGEEDGI
GAEGKLDHSALLTDPDQAADFVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHARLPNTHLVMHGSSSVPQD
LLEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFFVENPSKFDPREFLKPAREAAKLICKARF
EAFGSAGQASKIKPVALDKIAARYKAGELTQVVR
>Mature_353_residues
PLVSMRQLLDHAAENSYGLPAFNVNNLEQVQAIMEAAAETDSPVIMQASAGARKYAGEAFLRHLIDAAVEAYPHIPVVMH
QDHGQSPAVCMAAIRSGFSSVMMDGSLMEDGKTPSSYEYNVAVTREVVKFSHAIGVTVEAELGCLGSLETGMAGEEDGIG
AEGKLDHSALLTDPDQAADFVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHARLPNTHLVMHGSSSVPQDL
LEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFFVENPSKFDPREFLKPAREAAKLICKARFE
AFGSAGQASKIKPVALDKIAARYKAGELTQVVR

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=330, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=32.8267477203647, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788072, Length=334, Percent_Identity=31.437125748503, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1789293, Length=357, Percent_Identity=25.4901960784314, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322790, Length=377, Percent_Identity=25.9946949602122, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38245; Mature: 38114

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENSYGLPAFNVNNLEQVQAIMEAAAETDSPVIMQASAGARKYAGEA
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
FLRHLIDAAVEAYPHIPVVMHQDHGQSPAVCMAAIRSGFSSVMMDGSLMEDGKTPSSYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEE
NVAVTREVVKFSHAIGVTVEAELGCLGSLETGMAGEEDGIGAEGKLDHSALLTDPDQAAD
EHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHH
FVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHARLPNTHLVMHGSSSVPQD
HHHHCCCCEEEEEEECCCCCEEECCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCCHHH
LLEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFFVENPSKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PREFLKPAREAAKLICKARFEAFGSAGQASKIKPVALDKIAARYKAGELTQVVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENSYGLPAFNVNNLEQVQAIMEAAAETDSPVIMQASAGARKYAGEA
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
FLRHLIDAAVEAYPHIPVVMHQDHGQSPAVCMAAIRSGFSSVMMDGSLMEDGKTPSSYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEE
NVAVTREVVKFSHAIGVTVEAELGCLGSLETGMAGEEDGIGAEGKLDHSALLTDPDQAAD
EHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHH
FVKQTDCDALAIAIGTSHGAYKFTRKPTGDILAIDRIKAIHARLPNTHLVMHGSSSVPQD
HHHHCCCCEEEEEEECCCCCEEECCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCCHHH
LLEIIRQYGGDMKETYGVPVEEIVEGIKYGVRKINIDTDIRLAMTGAIRKFFVENPSKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PREFLKPAREAAKLICKARFEAFGSAGQASKIKPVALDKIAARYKAGELTQVVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]