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The map label for this gene is lpxA [H]

Identifier: 119898188

GI number: 119898188

Start: 2080900

End: 2081670

Strand: Reverse

Name: lpxA [H]

Synonym: azo1897

Alternate gene names: 119898188

Gene position: 2081670-2080900 (Counterclockwise)

Preceding gene: 119898189

Following gene: 119898187

Centisome position: 47.57

GC content: 66.41

Gene sequence:

>771_bases
ATGATCCACCCGACCGCCATCATTCACCCCGGCGCACGGCTGGGCGCCAATGTTGCCGTCGGTGCGTATTCCATCATCGG
CGAACACGTCGAGATCGGCGACGGCACCCGCATCGGGCCCCACGTCGTCGTCGAGGGCCACACCCGCATCGGCCGCGACA
ACGAGATCTTCCAGTTCTGCTCGATCGGCGCCTCGCCGCAGGACAAGAAGTACGACGACGAAGCGACCCGCCTCGAGATC
GGCGACCGCAACACCATCCGCGAGTTCTGCTCCTTCAACGTGGGCACCACGCAGGATGCGCACGTCACCCGCGTCGGCAG
CGACAACTGGATCATGGCTTACGTGCACATTGCGCACGACTGCCAGGTGGGCGACCACACCATCTTCGCCAACAACGCCA
CGCTTGCAGGGCATGTGCATGTCGGTGACTGGGCCATCCTTGGCGGCTTCACCGGCGTGCACCAGTTCTGCCGCGTGGGT
GCCCACAGCTTCTGCGGCGTCGGCACGGTACTGCTGCAGGACCTGCCTCCCTTCGTCACGGTTGCCGGCAACCCTGCTGC
GCCGCATGGCATCAACAGCGAAGGCCTGAAGCGCCGCGGCTACTCCGCGGACGCGATCGCCGCGATCAAGCGAGCCTACC
GCGCCTTGTACCGCTCCGGTCTCAAGCTCGACGAGGCGCGCGAGCGCATTGCGGAAATCGTCGCCGAGCACGCGGACGTG
GCGCCGTTCGCCGACTTCATCGCCCAGTCCTCCCGCGGCATCGTCAGGTGA

Upstream 100 bases:

>100_bases
CCCAGAGCAAGCGCAACATCTACAAGTACAAGGGCGTAGCGCGCGTGAATGGTGAAATCGCGACCGAAGCCGAACTGATG
TGCGCACTCAAGACCCTGTC

Downstream 100 bases:

>100_bases
CGGCATGGCGCCGCGAATCGCCATGGTCGCCGGAGAAGCCTCCGGCGATCTCCTCGCCAGTCACCTGATCCGCGCGATCC
GCGCGCGCGTGCCCGACGCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIHPTAIIHPGARLGANVAVGAYSIIGEHVEIGDGTRIGPHVVVEGHTRIGRDNEIFQFCSIGASPQDKKYDDEATRLEI
GDRNTIREFCSFNVGTTQDAHVTRVGSDNWIMAYVHIAHDCQVGDHTIFANNATLAGHVHVGDWAILGGFTGVHQFCRVG
AHSFCGVGTVLLQDLPPFVTVAGNPAAPHGINSEGLKRRGYSADAIAAIKRAYRALYRSGLKLDEARERIAEIVAEHADV
APFADFIAQSSRGIVR

Sequences:

>Translated_256_residues
MIHPTAIIHPGARLGANVAVGAYSIIGEHVEIGDGTRIGPHVVVEGHTRIGRDNEIFQFCSIGASPQDKKYDDEATRLEI
GDRNTIREFCSFNVGTTQDAHVTRVGSDNWIMAYVHIAHDCQVGDHTIFANNATLAGHVHVGDWAILGGFTGVHQFCRVG
AHSFCGVGTVLLQDLPPFVTVAGNPAAPHGINSEGLKRRGYSADAIAAIKRAYRALYRSGLKLDEARERIAEIVAEHADV
APFADFIAQSSRGIVR
>Mature_256_residues
MIHPTAIIHPGARLGANVAVGAYSIIGEHVEIGDGTRIGPHVVVEGHTRIGRDNEIFQFCSIGASPQDKKYDDEATRLEI
GDRNTIREFCSFNVGTTQDAHVTRVGSDNWIMAYVHIAHDCQVGDHTIFANNATLAGHVHVGDWAILGGFTGVHQFCRVG
AHSFCGVGTVLLQDLPPFVTVAGNPAAPHGINSEGLKRRGYSADAIAAIKRAYRALYRSGLKLDEARERIAEIVAEHADV
APFADFIAQSSRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=56.25, Blast_Score=297, Evalue=5e-82,
Organism=Escherichia coli, GI1786376, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27566; Mature: 27566

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPTAIIHPGARLGANVAVGAYSIIGEHVEIGDGTRIGPHVVVEGHTRIGRDNEIFQFC
CCCCCEEECCCHHHCCCEEHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHH
SIGASPQDKKYDDEATRLEIGDRNTIREFCSFNVGTTQDAHVTRVGSDNWIMAYVHIAHD
HCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEEEEEC
CQVGDHTIFANNATLAGHVHVGDWAILGGFTGVHQFCRVGAHSFCGVGTVLLQDLPPFVT
CCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
VAGNPAAPHGINSEGLKRRGYSADAIAAIKRAYRALYRSGLKLDEARERIAEIVAEHADV
ECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
APFADFIAQSSRGIVR
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIHPTAIIHPGARLGANVAVGAYSIIGEHVEIGDGTRIGPHVVVEGHTRIGRDNEIFQFC
CCCCCEEECCCHHHCCCEEHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHH
SIGASPQDKKYDDEATRLEIGDRNTIREFCSFNVGTTQDAHVTRVGSDNWIMAYVHIAHD
HCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEEEEEC
CQVGDHTIFANNATLAGHVHVGDWAILGGFTGVHQFCRVGAHSFCGVGTVLLQDLPPFVT
CCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
VAGNPAAPHGINSEGLKRRGYSADAIAAIKRAYRALYRSGLKLDEARERIAEIVAEHADV
ECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
APFADFIAQSSRGIVR
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA