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The map label for this gene is lpxB

Identifier: 119898187

GI number: 119898187

Start: 2079720

End: 2080895

Strand: Reverse

Name: lpxB

Synonym: azo1896

Alternate gene names: 119898187

Gene position: 2080895-2079720 (Counterclockwise)

Preceding gene: 119898188

Following gene: 119898186

Centisome position: 47.55

GC content: 67.43

Gene sequence:

>1176_bases
ATGGCGCCGCGAATCGCCATGGTCGCCGGAGAAGCCTCCGGCGATCTCCTCGCCAGTCACCTGATCCGCGCGATCCGCGC
GCGCGTGCCCGACGCGGAATTCTTCGGCATCGGCGGCCCCAAGATGCAGGCCGAGGGCTTCGATGCCCGCTGGCCCTGCG
AACTGCTTGCAGTGCACGGTTATGTCGACGCGCTGAAGCGCTACCGGGAATTGTCGGGCATCCGCAAGAAGCTGCTGAAG
CAGGTGCGCCGCGAGCGCCCGGACGCATTCATCGGCGTCGACGCGCCCGATTTCAACCTGTGGCTCGAAGGCAAGATCAA
GGCCGCCGGCATCCCCGCCATCCATTTCGTCAGCCCGTCCATCTGGGCCTGGCGCGGGGGGCGGATCAAACGGATCGCGC
GTTCGGTGACACGCATGTTGTGCATGTTCCCGTTCGAGCCGGAACTCTACGAGCGCGCCGGCGTACCGGTCAGCTACGTG
GGGCATCCGCTGGCCGACGTGTTTCCGCTCGAACCGGACCGCGCCGCGGCGCGGGAGCGGCTGGACATCGCCCCTGAACG
CAAGGTCGTCGCCCTGCTGCCGGGCAGCCGCCAGTCCGAAGTGCGCAATCTCGGCGAACTCTTCATCGAAACCGCGGCGA
TGCTCGCCCAGCGCCATCCCGACGTGCTCTTCCTGGTGCCTTTGGCCACGCGCGAGACGCGCGAGTTGTTCAGCGCGGCG
CTTGCGCGCAACAAGGGTGACGAATTGCCGCTGCGCATGCTGTTCGGCCACGCCGTCGATGCGATGACCGCGGCGGACGC
GGTGCTCGTCGCAAGCGGCACGGCCTCGCTGGAGGCGGCGCTGCTCAAGCGGCCGATGGTGATCACCTACCGCATGGGCA
AGTGGCAGTACCGGCTGATGAAGCGCATGGCCTATCTGCCCTGGATCGGCTTGCCCAACATCCTGTGCAGGGAAGGGCTG
GTGCCGGAACTCGTGCAGGACGACGCGACGCCGCCGAAGCTGGCGGACGCGCTGGAACGCTGGCTCGTCGATCCCGCCGC
CTGCGCTGCATTGACCGAACGCTTCACCGCACTCCATCACAGCCTGCGGCAAAACACCGCCGAAAAGGCCGCCGCAGCCG
TCCTGCCGTATCTATCGAGTAGCGCATCGTGCCAGCCAGTCAGCGTCTCCGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCGAGCGCATTGCGGAAATCGTCGCCGAGCACGCGGACGTGGCGCCGTTCGCCGACTTCATCGCCCAGTCCTCCCG
CGGCATCGTCAGGTGACGGC

Downstream 100 bases:

>100_bases
TCTGCGGGGTCGACGAAGCCGGCCGCGGCCCGCTATGCGGCCCCGTAGTCGCCGCGGCCGTCATCCTCGACCCCGCGCGC
CCGATCGACGGCCTGGCCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAPRIAMVAGEASGDLLASHLIRAIRARVPDAEFFGIGGPKMQAEGFDARWPCELLAVHGYVDALKRYRELSGIRKKLLK
QVRRERPDAFIGVDAPDFNLWLEGKIKAAGIPAIHFVSPSIWAWRGGRIKRIARSVTRMLCMFPFEPELYERAGVPVSYV
GHPLADVFPLEPDRAAARERLDIAPERKVVALLPGSRQSEVRNLGELFIETAAMLAQRHPDVLFLVPLATRETRELFSAA
LARNKGDELPLRMLFGHAVDAMTAADAVLVASGTASLEAALLKRPMVITYRMGKWQYRLMKRMAYLPWIGLPNILCREGL
VPELVQDDATPPKLADALERWLVDPAACAALTERFTALHHSLRQNTAEKAAAAVLPYLSSSASCQPVSVSA

Sequences:

>Translated_391_residues
MAPRIAMVAGEASGDLLASHLIRAIRARVPDAEFFGIGGPKMQAEGFDARWPCELLAVHGYVDALKRYRELSGIRKKLLK
QVRRERPDAFIGVDAPDFNLWLEGKIKAAGIPAIHFVSPSIWAWRGGRIKRIARSVTRMLCMFPFEPELYERAGVPVSYV
GHPLADVFPLEPDRAAARERLDIAPERKVVALLPGSRQSEVRNLGELFIETAAMLAQRHPDVLFLVPLATRETRELFSAA
LARNKGDELPLRMLFGHAVDAMTAADAVLVASGTASLEAALLKRPMVITYRMGKWQYRLMKRMAYLPWIGLPNILCREGL
VPELVQDDATPPKLADALERWLVDPAACAALTERFTALHHSLRQNTAEKAAAAVLPYLSSSASCQPVSVSA
>Mature_390_residues
APRIAMVAGEASGDLLASHLIRAIRARVPDAEFFGIGGPKMQAEGFDARWPCELLAVHGYVDALKRYRELSGIRKKLLKQ
VRRERPDAFIGVDAPDFNLWLEGKIKAAGIPAIHFVSPSIWAWRGGRIKRIARSVTRMLCMFPFEPELYERAGVPVSYVG
HPLADVFPLEPDRAAARERLDIAPERKVVALLPGSRQSEVRNLGELFIETAAMLAQRHPDVLFLVPLATRETRELFSAAL
ARNKGDELPLRMLFGHAVDAMTAADAVLVASGTASLEAALLKRPMVITYRMGKWQYRLMKRMAYLPWIGLPNILCREGLV
PELVQDDATPPKLADALERWLVDPAACAALTERFTALHHSLRQNTAEKAAAAVLPYLSSSASCQPVSVSA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=371, Percent_Identity=45.822102425876, Blast_Score=311, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_AZOSB (A1K6Q8)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933400.1
- STRING:   A1K6Q8
- GeneID:   4609754
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1896
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   A1K6Q8
- ProtClustDB:   CLSK767007
- BioCyc:   ASP62928:AZO1896-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43155; Mature: 43024

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRIAMVAGEASGDLLASHLIRAIRARVPDAEFFGIGGPKMQAEGFDARWPCELLAVHG
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
YVDALKRYRELSGIRKKLLKQVRRERPDAFIGVDAPDFNLWLEGKIKAAGIPAIHFVSPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECEEEECCCCEEEECCCC
IWAWRGGRIKRIARSVTRMLCMFPFEPELYERAGVPVSYVGHPLADVFPLEPDRAAARER
CEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCCHHHCCCCCCCHHHHHHH
LDIAPERKVVALLPGSRQSEVRNLGELFIETAAMLAQRHPDVLFLVPLATRETRELFSAA
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
LARNKGDELPLRMLFGHAVDAMTAADAVLVASGTASLEAALLKRPMVITYRMGKWQYRLM
HHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHH
KRMAYLPWIGLPNILCREGLVPELVQDDATPPKLADALERWLVDPAACAALTERFTALHH
HHHHHCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLRQNTAEKAAAAVLPYLSSSASCQPVSVSA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
APRIAMVAGEASGDLLASHLIRAIRARVPDAEFFGIGGPKMQAEGFDARWPCELLAVHG
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
YVDALKRYRELSGIRKKLLKQVRRERPDAFIGVDAPDFNLWLEGKIKAAGIPAIHFVSPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECEEEECCCCEEEECCCC
IWAWRGGRIKRIARSVTRMLCMFPFEPELYERAGVPVSYVGHPLADVFPLEPDRAAARER
CEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCCHHHCCCCCCCHHHHHHH
LDIAPERKVVALLPGSRQSEVRNLGELFIETAAMLAQRHPDVLFLVPLATRETRELFSAA
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
LARNKGDELPLRMLFGHAVDAMTAADAVLVASGTASLEAALLKRPMVITYRMGKWQYRLM
HHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHH
KRMAYLPWIGLPNILCREGLVPELVQDDATPPKLADALERWLVDPAACAALTERFTALHH
HHHHHCCCCCCCHHHHHCCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLRQNTAEKAAAAVLPYLSSSASCQPVSVSA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA