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The map label for this gene is ppiB [H]

Identifier: 119897347

GI number: 119897347

Start: 1135647

End: 1136141

Strand: Reverse

Name: ppiB [H]

Synonym: azo1056

Alternate gene names: 119897347

Gene position: 1136141-1135647 (Counterclockwise)

Preceding gene: 119897348

Following gene: 119897346

Centisome position: 25.96

GC content: 62.42

Gene sequence:

>495_bases
ATGGCAGTGAACCTGCACACCAACTACGGCGTCATCACCCTCGAACTCGACGCCGAGAAGGCGCCGGTGACCGTCGAGAA
CTTCCTGACCTACGTGAAGGACGGCCACTACGACAACACCGTCTTCCACCGCGTCATCGACGGCTTCATGATCCAGGGCG
GCGGCTTCGAGCCCGGCATGAAGCAAAAGCCGACCCGCGAGCCGATCAAGAACGAAGCCGACAACGGCCTCAAGAACGAA
CGCGGCACCATCGCCATGGCGCGCACCCAGGCGCCCCACTCCGCCTCTGCGCAGTTCTTCATCAATGTCGCCGACAACGA
CTTCCTCAACTTCCGTTCGCAGGACCTGCAGGGCTGGGGCTACTGCGTGTTCGGCCGCGTTACCGCCGGACTGGACGTGG
TCGATGCGATCCGCAAGGTCAAGACGGGCTCGAGCGGCTTCCATCAGGATGTGCCGAAGGAAGACGTGATCATCGAGCGG
GCCGAAGTTGTCTGA

Upstream 100 bases:

>100_bases
CACCAGAATGTCCCGGCCGAGCCGGTCGTCATCCAGTCGGCGCGCGTGATCGAAGCGCAGCCGGCCGGCCCCGCAGCCCG
ATAAGCACAAGGAGCACACC

Downstream 100 bases:

>100_bases
TCCCCGTACGCAAGCGGCCGCCACCGGCGGCCGTGCCGGCGACGAGCCGGAAGCCGCGTCCGTCGCGCTTCCGGCTTTCT
TCATTTCGGACCTCCACCTG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MAVNLHTNYGVITLELDAEKAPVTVENFLTYVKDGHYDNTVFHRVIDGFMIQGGGFEPGMKQKPTREPIKNEADNGLKNE
RGTIAMARTQAPHSASAQFFINVADNDFLNFRSQDLQGWGYCVFGRVTAGLDVVDAIRKVKTGSSGFHQDVPKEDVIIER
AEVV

Sequences:

>Translated_164_residues
MAVNLHTNYGVITLELDAEKAPVTVENFLTYVKDGHYDNTVFHRVIDGFMIQGGGFEPGMKQKPTREPIKNEADNGLKNE
RGTIAMARTQAPHSASAQFFINVADNDFLNFRSQDLQGWGYCVFGRVTAGLDVVDAIRKVKTGSSGFHQDVPKEDVIIER
AEVV
>Mature_163_residues
AVNLHTNYGVITLELDAEKAPVTVENFLTYVKDGHYDNTVFHRVIDGFMIQGGGFEPGMKQKPTREPIKNEADNGLKNER
GTIAMARTQAPHSASAQFFINVADNDFLNFRSQDLQGWGYCVFGRVTAGLDVVDAIRKVKTGSSGFHQDVPKEDVIIERA
EVV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=35.9756097560976, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=35.9756097560976, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=35.9756097560976, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=32.1212121212121, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=34.9693251533742, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=35.2201257861635, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI64276486, Length=137, Percent_Identity=34.3065693430657, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=71.4285714285714, Blast_Score=247, Evalue=3e-67,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=58.0246913580247, Blast_Score=183, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17532641, Length=172, Percent_Identity=34.3023255813954, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.2465753424658, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=163, Percent_Identity=32.5153374233129, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320510, Length=162, Percent_Identity=35.1851851851852, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=30.952380952381, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=33.5365853658537, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=159, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922912, Length=159, Percent_Identity=34.5911949685535, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18174; Mature: 18042

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNLHTNYGVITLELDAEKAPVTVENFLTYVKDGHYDNTVFHRVIDGFMIQGGGFEPGM
CEEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCC
KQKPTREPIKNEADNGLKNERGTIAMARTQAPHSASAQFFINVADNDFLNFRSQDLQGWG
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
YCVFGRVTAGLDVVDAIRKVKTGSSGFHQDVPKEDVIIERAEVV
EEEEEEHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
AVNLHTNYGVITLELDAEKAPVTVENFLTYVKDGHYDNTVFHRVIDGFMIQGGGFEPGM
EEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCC
KQKPTREPIKNEADNGLKNERGTIAMARTQAPHSASAQFFINVADNDFLNFRSQDLQGWG
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
YCVFGRVTAGLDVVDAIRKVKTGSSGFHQDVPKEDVIIERAEVV
EEEEEEHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]